$VAR1 = undef;

Summary for peptidase M06.001: immune inhibitor A peptidase (Bacillus sp.)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Nameimmune inhibitor A peptidase (Bacillus sp.)
Other namesInhA g.p. (Bacillus thuringiensis), InhA1 peptidase, thuringalysin, IgAlysin
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(D) >> Family M6 >> Subfamily (none) >> M06.001
Holotypeimmune inhibitor A peptidase (Bacillus sp.) (Bacillus thuringiensis), Uniprot accession P23382 (peptidase unit: 41-687), MERNUM MER0001164
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (12 cleavages)
BiotechnologyContributes to use of organism in biological pest control.
PhysiologyDestroys proteins attacin and cecropin of the antibacterial system of the host insect, and kills insect larvae (Dalhammar & Steiner, 1984).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/k/aScissile bondvi/-/kqa/- (based on 24 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 4 2 4 2 5 2 2
Pro 2 2 1 0 0 2 0 1
Ala 3 2 2 5 1 0 4 4
Val 1 2 1 2 7 3 0 4
Leu 2 0 0 3 0 2 0 1
Ile 4 4 0 0 6 4 1 2
Met 0 0 0 0 0 0 0 0
Phe 0 2 0 0 2 0 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 2 0 0 0 0 0 0
Ser 1 1 1 0 1 0 1 0
Thr 0 0 0 0 1 0 0 0
Cys 1 1 1 0 1 0 0 2
Asn 0 0 0 2 2 1 0 2
Gln 0 0 3 2 1 0 5 2
Asp 1 0 3 1 0 0 2 2
Glu 1 0 2 0 0 2 0 0
Lys 6 2 8 4 0 3 7 0
Arg 1 2 0 1 0 2 2 2
His 0 0 0 0 0 0 0 0