$VAR1 = undef;
Summary for peptidase C74.001: pestivirus NS2 peptidase
| Names | |
|---|---|
| MEROPS Name | pestivirus NS2 peptidase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(C) >> Family C74 >> Subfamily (none) >> C74.001 |
| Holotype | pestivirus NS2 peptidase (bovine viral diarrhea virus 1), Uniprot accession P19711 (peptidase unit: 1441-1522), MERNUM MER0038321 |
| History | Identifier created: Merops 7.40 |
| Activity | |||
|---|---|---|---|
| Catalytic type | Cysteine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Physiology | Responsible for single cleavage between NS2 and NS3 of the bovine viral diarrhea virus polyprotein, a cleavage that is correlated with cytopathogenicity (Lackner et al., 2006). The peptidase is activated by its interaction with "J-domain protein interacting with viral protein" (Jiv) (Rinck et al., 2001; Lackner et al., 2006). | ||
