Summary for peptidase C02.018: calpain-10

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma


MEROPS Namecalpain-10
Other namesCAPN8 g.p. [obs.] (Mus musculus), CAPN10 g.p. (Homo sapiens, Mus musculus)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C2 >> Subfamily A >> C02.018
Holotypecalpain-10 (Homo sapiens), Uniprot accession Q9HC96 (peptidase unit: 43-304), MERNUM MER0013510
History Identifier created: MEROPS 5.3 (4 December 2000)
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative
mouse: putative
PhysiologyIt is reported that variations in the gene are associated with type 2 diabetes, and affect blood glucose levels through changes in the early insulin secretory response (Lynn et al., 2002). The association with type 2 diabetes is found in Mexican Americans but not in Japanese (Horikawa et al., 2003).
Other databases WIKIPEDIA
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CAPN10 2q37.3 ENSG00000142330 11132 CAPN10 605286
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Capn10 1:D ENSMUSG00000026270 23830 MGI:1344392