$VAR1 = undef;

Summary for peptidase A01.071: pepsin A5 (Homo sapiens)

Names
MEROPS Name	pepsin A5 (Homo sapiens)
Other names	pepsinogen A5, PGA5 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.071
Holotype	pepsin A5 (Homo sapiens), Uniprot accession P0DJD9 (peptidase unit: 63-388), MERNUM MER0037291
History	Identifier created: MEROPS 6.8 (20 August 2004)

Activity
Catalytic type	Aspartic
NC-IUBMB	Not yet included in IUBMB recommendations.
Pathways	KEGG	Protein digestion and absorption
Other databases	TREEFAM	http://www.treefam.org/family/TF314990
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/l-/l/-/- (based on 10 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	2	1	0	0	0	0	1
Pro	0	1	0	0	0	0	1	1
Ala	1	1	1	1	1	0	1	0
Val	1	1	1	0	2	1	1	1
Leu	2	2	2	4	2	3	1	3
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	1	2	2	0	1	0
Tyr	0	0	0	1	2	2	1	0
Trp	0	0	0	0	0	0	0	0
Ser	0	1	0	0	0	0	0	0
Thr	0	0	1	0	0	1	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	0	0	0	1
Asp	0	0	0	1	0	2	0	0
Glu	2	1	1	1	0	1	1	0
Lys	0	0	1	0	1	0	1	2
Arg	2	1	0	0	0	0	0	0
His	1	0	1	0	0	0	0	0

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
PGA5	11q13		ENSG00000172647	5222	PGA5	169720