$VAR1 = undef;

Summary for peptidase A01.002: pepsin B

Names
MEROPS Name	pepsin B
Other names	parapepsin I, pig gastric gelatinase

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.002
Holotype	pepsin B (Canis lupus familiaris), Uniprot accession Q8SQ41 (peptidase unit: 61-390), MERNUM MER0020009
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.2
Enzymology	BRENDA database
Physiology	Occurs as an active peptidase in the dog stomach (Narita et al., 2002). May contribute to proteolysis in the vertebrate stomach.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Pepsin_B
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	P/aeg/Ge/Flafy/R/L/- (based on 25 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	4	12	0	1	0	0	2
Pro	17	0	0	0	0	0	1	1
Ala	0	9	2	1	4	0	1	0
Val	1	1	0	0	2	1	1	1
Leu	1	0	1	2	10	1	18	1
Ile	0	1	0	0	0	0	0	0
Met	0	0	0	1	0	0	0	0
Phe	0	0	1	20	4	0	0	0
Tyr	0	0	0	1	3	2	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	1	0	0	0	0	0	0
Thr	0	1	0	0	0	1	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	0	0	1	0
Asp	0	0	0	0	0	0	0	0
Glu	2	4	6	0	1	2	0	0
Lys	0	2	1	0	0	0	0	1
Arg	2	1	0	0	0	17	0	0
His	0	0	1	0	0	0	0	0