Alignment for family M42

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   1 MVDWKLMQEIIEAPGVSGYEHLGIRDIVVDVLKE-----------VAD-EVKV-DKLGNVIAHFKG---SS-PRIMVAAHMDKIGVMVNHIDKDGYLHIVPI-----GGVLPETLVAQRIRFFTEK-GE-RYGVVGVLPPHL-RRG-QEDK--GSKIDWDQIVVDVGASSKEEAE-EMGFRVGTVGEFAPNFTRLNEHR-FATPYLDDRICLYAMIEAARQLGD---HE----ADIYIVGSVQEEVGLR--GARVA------SYAINPEVGIAMDVTFAK------Q----PHDKG-KI-VPELGKG---PVMD-------VGPNINPKLRAFADEVAKKYEIPLQVEPSPRPTGTDANVMQ-INREGVATAVLSIPIRYMHSQVELADARDVDNTIKLAKALLEELKPMDFTP-----   1
   2 MVDWELMKKIIESPGVSGYEHLGIRDLVVDILKD-----------VAD-EVKI-DKLGNVIAHFKG---SA-PKVMVAAHMDKIGLMVNHIDKDGYLRVVPI-----GGVLPETLIAQKIRFFTEK-GE-RYGVVGVLPPHL-RRE-AKDQ--GGKIDWDSIIVDVGASSREEAE-EMGFRIGTIGEFAPNFTRLSEHR-FATPYLDDRICLYAMIEAARQLGE---HE----ADIYIVASVQEEIGLR--GARVA------SFAIDPEVGIAMDVTFAK------Q----PNDKG-KI-VPELGKG---PVMD-------VGPNINPKLRQFADEVAKKYEIPLQVEPSPRPTGTDANVMQ-INREGVATAVLSIPIRYMHSQVELADARDVDNTIKLAKALLEELKPMDFTP-----   2
   3 MVDYELLKKVVEAPGVSGYEFMGIRDVVIEEIKD-----------YVD-EVNV-DKLGNVIAHKKG---EG-PKVMIAAHMDQIGLMVTHIEKNGFLRVAPI-----GGIDPRTLIAQRFKVWIDK-GKFIYGVGGSVPPHI-QK--PEDR--KKAPDWDQIFIDIGAESKEEAE-ELGVKIGTIVTWDGRLERLGKHR-FVSIAFDDRIAVYTLIETARQLQD---TK----ADIYFVATVQEEVGLR--GARTS------AFGINPDYGFAIDVTIAA------DVPGTPEHKQ----VTQLGKGTAIKIMD-------RSVICHPTIVRWMEELAKKYEIPYQWD-ILLGGGTDAGAIH-LTRAGVPTGAVSIPARYIHSNAEVVDERDVDASVKLMVKVLEHIHELKI-------   3
   4 ------LNKLTSIPRVTGSER-TFAPSIAEILEP-----------HCD-AIRI-DPWGNVEGILN---PGGKPSIMIAAHVDQIGIIVKEVTNEGYIKFDGV------GWDPRVLYGSRVKLITGK-GI-VRGVIGVVPAHF-LRVYKELE--EKKIEIKDLVIDIGARSKEEAE-SMGIKPGTYGVPDYDPISLGSE-FFSSPGLDNAAGVATMI-YGAMLSREG-GGID--AEVHFTATIQEEIGLR--GAEMM------AYRLKPEVAIAIDVTFAE-QPMLPE---APRIS--------LGKGPVI---S-------RGPIYHPEVVELIERAAEENEIPRQYEADFRGAGTDTWVIQ-VARGGVKTALISIPLRYMHSPCEVISLKDV--------------------------   4
   5 MKLIEMLKEITQVPGISGYEE-RVREKIIEWIKD-----------YAD--YKV-DEIGNLIVEL----GEGEVKAVFMAHMDEIGLLITGITQDGKLRFRKV-----GGIDDRLLYGRHVDVITEN-GK-LDGVIGALPPHL-NVKGV-----KDVVPWYQLTIDIGAESKEEAL-SLGVKPLDYAVFKKHFSVLNNKI-VSTRSLDDRFGVVALVQAIRNLVD---HELS--GKFIFAFTVQEEIGLK--GAKFL------AEKYSPEYAFAIDSFACC-SELTGD--------------VRLGGGAVIRAVD-------NSAIYSRDLARKVWEIAEKNNIPIQIG--VTGGGTDASVFQ----HKSKVLALSVPMKYLHSEVEMLNVKDLEALIALIEAITFEI------------   5
   6 MSMIEKLKKFTQIPGISGYEE-RIREEIIREIKD-----------FAD--YKV-DAIGNLIVEL----GEGEERILFMAHMDEIGLLITGITDEGKLRFRKV-----GGIDDRLLYGRHVNVVTEK-GI-LDGVIGATPPHL-SLERD-----KSVIPWYDLVIDIGAESKEEAL-EL-VKPLDFAVFKKHFSVLNGKY-VSTRGLDDRFGVVALIEAIKDLVD---HELE--GKVIFAFTVQEEVGLK--GAKFL------ANHYYPQYAFAIDSFACC-SPLTGD--------------VKLGKGPVIRAVD-------NSAIYSRDLARKVWSIAEKNGIEIQIG--VTGGGTDASAFQ----DRSKTLALSVPIKYLHSEVETLHLNDLEKLVKLIEALAFEL------------   6
   7 ------LKELSDIPGVSGFEG-KVREFIKEKIKD-----------KVD-YIET-DKLGNLIALKKG--K-VNKKLMITAHMDEVGFIVSNIEEDGKISIIPL-----GTIDPRVVLGKKVVIGEKQ----ILGVIGSKPVHL-MEGY-E----KV--SFENIKVDIGATKKQEA--ESKVKIGDFVSFAPNAMVHEEW--ISGKALDDRGGCSILMDLI--LSG---LDLY--YDTFFAFVIQEETGLR--GSGSC------AFKINPDFAIVVETTTSG------D---NPEFPPDRR-SSELGKGPVITPAH-------RGYVNDERLFNFAVKVAKENNIPYQIKRR-TVGGTDAARIA-ITT-GTPSLVISIPSRYIHSPMSVVNISDYQNTLKLLSLIL---------------   7
   8 --MKLFLKELSDIPGVSGFEG-KVREFIKEKIKD-----------KVD-QIEV-DKLGNLIAFKKG--K-VNKKLMISAHMDEVGFIVSNIEEDGKLSILPL-----GSIDPRVVLGKKVVIGEKQ----ILGVIGSKPIHL-MEGY-E----KV--SFENIKVDIGATKKQEA--EAKVKIGDFVSFAPNAMIHGEW--ISGKALDDRGGCSLLIDLI--LKD---LDLY--YDTFFAFVIQEETGLR--GSGPC------AFKIKPDLAIVVETTTSG------D---NPEFPEARR-SSELGKGPVITPAH-------RGYVNDERLFNFAVKVAEENKIPYQIKRR-TAGGTDAARIA-ITT-GTPSLVISIPSRYIHSPICVLNINDYRNTFKLLSLILT--------------   8
   9 ------LKELSMMPGVSGDEG-KVRDFIKSKIEG-----------LVD-NLYT-DVLGNLIALKRG--RDSSKKLLVSAHMDEVGFVVSKIEKDGKVSFLPV-----GGVDPRILPGKVVQV--KN----LKGVIGYRPIHL-QRDE-E----NTPPRFENLRIDFGFSSADEA--KKYVSIGDYVSFVSDYIEKNGR--AVGKAFDDRAGCSVLIDVL--ESG---VSPA--YDTYFVFTVQEETGLR--GSAVV------VEQLKPTCAIVVETTTAG------D---NPELEERKW-ATHLGDGPAITFYH-------RGYVIPKEIFQTIVDTAKNNDIPFQMKRR-TAGGTDAGRYA-RTAYGVPAGVISTPARYIHSPNSIIDLNDYENTKKLIKVLV---------------   9
  10 MANIELIKKLSNSFGISGFED-EVIEILKSEVRG-----------YVD-SFEV-DPLKNFIAVKSL--ELAKPIVMLNAHMDEVGLIVKGFTSEGYLKFSKV-----GGIDDRVLLGKRVVIGKNR----VKGVIATVPIHL-QEQSER----NRVEKAKDMVIDIGVKSKEEAE-KL-VSLGDFVGFDVKFEQLSENT-FVGKALDDRLGCALITEILK-------EKFN--FPIVALFSSQEEIGLR--GATVG------AFKYTPQISITIEGTISA------D---FPDVSDHEK-CTTVGNGPVITIKD-------NSVITDHELRGKLVKIAEKLKVPYQFKQ-VFVGGTDSSRIQ-LTKAGVKVLVVAVPVRYIHSPISLFNINDYENTKKLIIEFLKSL------------  10
  11 --MKELIKKLTEIKSPSGREE-NIRSAILEELKE-----------YID-GYEI-DKLGNLIVWKKG---KKEGKILLDAHMDEIGVLATHIDEKGFIRIEPI-----GGVSPYNLLGSSIAF--PN-I--E-GFVGVEGETS-EEL-SKNL---KNLDFDKIFVDIGAKNKLEAE-KL-VPPGTFGVYSASFKDLGE-R-IVSKAMDDRIGCAIIIEVFKKSNP---Y-----YTLYGTFSIQEEIGLV--GASVV------AFNIKPDLAIAVDVTAHS------D---TPKGPK-RM-SLELGKGPAIKIKD-------SASISDRRIVEKLKNIAERNNIPYQIE-ILLRGGTNAAALQ-RTGEGIPAGTLSIPTRYVHSPHEMVDIKDVENAVKIL-------------------  11
  12 --MKELIKKLTEIKSPSGRED-NIRNAILEELKG-----------YID-GYEI-DKLGNLIVWKKG---KKDGKILLDAHMDEIGVLATYIDEKGFIRIEPI-----GGVSPYNLLGSSIAF--PQ-A--E-GFVGVEGETL-EEL-SKNI---KNLDFDKIFVDIGAKSREEAE-KL-VPPGTFGVYSANFKDLGE-R-LVSKAMDDRIGCAIIIEVFKRSNP---Y-----YTLYGTFSIQEEIGLV--GASVV------AFDIKPDLAIAIDVTAHS------D---TPKGPK-RM-SLELGKGPAIKIKD-------SASISDRRIVEKLKNIAEKNGIPYQIE-ILLRGGTNAAALQ-RTGEGIPAGTLSIPTRYVHSPHEMIDINDVENAIRIL-------------------  12
  13 --MKELIRKLTEAFGPSGREE-EVRSIILEELEG-----------HID-GHRI-DGLGNLIVW-KG---SGEKKVILDAHIDEIGVVVTNVDDKGFLTIEPV-----GGVSPYMLLGKRIRF--EN-G--TIGVVGMEGETT-EER-QENV---RKLSFDKLFIDIGANSREEAQ-KM-CPIGSFGVYDSGFVEVSG-K-YVSKAMDDRIGCAVIVEVFKRIKP---A-----VTLYGVFSVQEEVGLV--GASVA------GYGVPADEAIAIDVTDSA------D---TPKAIK-RH-AMRLSGGPALKVKD-------RASISSKRILENLIEIAEKFDIKYQME-VLTFGGTNAMGYQ-RTREGIPSATVSIPTRYVHSPSEMIAPDDVEATVDLLIRYLGA-------------  13
  14 EDMFDLLKKFTGIVGVSGNEE-EIREAIIEEIKE-----------CVD-EIKV-DTLGNLIAVKKG---KG-KKIMVAAHMDEIGVMVTYIDDKGFLRFSAV-----GGVSRYDCIGQRVKF--KN-G--VVGAV-----YY-EEK-LEDM---KNLQLSKMYIDIGARSREEAL-KM-VNIGDVACFVGDAVLQGD-T-VISKALDNRSGCAVVVKAIKELKK---TD----NEIYFVFTVQEEVGLR--GAKTA------AFSIKPDIAIAVDVTMTG------D---TPES-H-PM-EVKCGGGPAIKVKD-------RSVICHPEVRKLLEESAKRNNIPYQLE-ILEAGGSDPGSIH-LTAGGIPSGAISIPVRYVHSPVETASMSDINNAVKLLVEAIC--------------  14
  15 ------IEKLVKVFGPSSRED-KVKNLIKEELKK-----------CEC-EISI-DKFGNLIAHIPQ---NG-PKLMLASHLDTIGFIITDVDKNGLIRFTSI-----GGLRTSFLLGSRVLF--EN-G--ILGTI-----YY-DDR--ENLWEPKEFKIEKYFIDIGAKSKKDAL-NL-VSIGMEGIFYPQFFLNGD-R-IISPSLDDRSGCAVLVELLKNVKK---KSLK--YDLYAVFTVQEEVGVK--GARTS------TYEITPDFGIAVDVTTAG------D---FLDP-H-IN-ALELGKGPAIKVMD-------GGMITNTDLRNELVNIARKNNIPYQLE-VITGGTTDAFAMQ-ITKEGVKTAAISIPTRYVHTQGELADINDIKNTVALLKNFI---------------  15
  16 MEVKEILKNLSNLDGPSGYEF-PVIKYIKDVAEK-----------IAPVKTLI-DNHGNLIVRKKG--D-G-RKIALFAHTDEIAFVITKKEFGNYFRIHTF-----GGVDPKVVISQRLRIHTKE-GI-SYGIVGMLEPHL-QNEEIR----QKNITFDDLFIDV-----LDK--SDSVQIGDLATFDSEAFDLNERY-IAGKALDNRASCATLLYTLELLNQ---FIVN--ADIYFVFSVREEDGVS--GAVNA------AYKINPDLAIVLDVTHGD-I----L---RPSYPK-----IETGKGPVLDI----------GPMVNYEYFDKIKNLAEKLSVNYQIEPNGDHSHTDTDRIQ-ITREGIPTLLISIPLRYMHTPYEVVNIRDMEETARLLSFFLA--------------  16
  17 VEIKEVLKNLSNLDGPSGYEQ-LVLEYIENVAKK-----------IADVETNI-DKHGNLIVRRPG--K-G-KRIALFAHTDEIAFVITKKEFGNYFRIHTF-----GGVDPKVVISQRLRIHTKE-GI-SYGVVGMLEPHL-QTEEIR----QKNITFDDLFIDI-----VEK--ADKVQIGDLATFDSEAFELNEKY-IAGKALDNRASCTALLYTLELLNQ---FIVS--GDIYFVFSVREEDGVS--GAINA------SYQINPELAIVLDVTHGD-I----Q---RPSYPK-----IETGKGPVLDI----------GPMIDYDYFNKIKNLAEKLSVNYQIEPNGNHSSTDTDSIQ-IAREGISTLLISIPLRYMHTPYEVVNIRDIEETARLLSFFLA--------------  17
  18 METGKLLMELSNLDGPSGYET-NVVSYIKSVIEP-----------FVD-EAKT-TRHGSLIGYKKG--K-GIGKLAFFAHVDEIGFVVSKVE-GQFARLEPV-----GGVDPKVVYASKVRIYTKN-GI-ERGVIGMLAPHL-QDSESR----KKVLTYDEIFVDL-----SLC--ERDVRVGDIAVIDQTAFETNGK--VVGKALDNRASCGVLVKVLEFLKR---YDHP--WDVYVVFSVQEETGCL--GALTG------AYEINPDAAIVMDVTFAS------E---PPFSDH-----IELGKGPVIGL----------GPVVDRNLVQKIIEIAKKHNVSLQEEAVGGRSGTETDFVQ-LVRNGVRTSLISIPLKYMHTPVEMVDPRDVEELARLLSLVAVELEV----------  18
  19 ---YELLRKLCEAPGVPGAET-PVKEIFLEAVKP-----------LID-EIEE-DPLGNVLLRKKG----KGPRVLIDAHLDEVAFMVAGI-EDSFIRVVPL-----GGVDPKIFYGQRLEVWGRK-R--LPAVVTSYPPHL-GQS-------KKDFTIEELYLDVGLSTEKVAE-LVKI--GDLVTF--PAYFEETEEAIMAKALDDRVGLFVIFQALAQAKS------K--VDLFISATVQEEVGLR--GAQGL------KIKEALDAVLAIEGTFAA------D---IPGVPGHLQ-ATKIAKGPEIRLCD-------ARFVADRNLALGLAELATQKNIPHQLVV-KNKGSTNATAFQ-VVRGAIRSTAISVPVRYLHTPVNLAFKKDIEATIELLKAFLEN-------------  19
  20 -------LSLASAP--PGFED-EVREILKEELEG-----------RVD-ELQE-DGFGN-LYAVKG----SGRKVMFAAHMDEVAMMVRHIDERGFLRVVAL-----GGLSPSQLVAQRVVVHGKV-K--LRGIVGTLPAHM-GEE-------KIP-KMDELYVDVGASSGEEAR-SLGIRPGTLITFDSPFIYQPETGSLIGKALDDRLGCFLLAEALKSVEP------G--EKIYAVFTCEEERGLR--GAQVA------ANRVRPDLAFVLEGTIAS------D---VPEVQEYNY-ITQLGKGPAIRVMD-------RGLIVKGWLLESIIARAEGLGIPYQLQL-SPVSSTDAAPIS-LSGDGVAVGVISVPARYIHSPQALAKVSDIENSLKLVKSLM---------------  20
  21 -MNLELLRQVCVTPGAPGFED-KIRDFIIQEVAP-----------LVD-AVRV-DNMGSVIAIVEG--KNTEKTMMAAAHMDEIGFMVRHIDDKGFIKFLPL-----GGFDAKTLTAQRVIVHGKK-D--LIGVMGVKPIHV-MSPAER----TKLPEVTDFFIDLGM-SKEEVE-KY-VSVGDSVTRERDLVEMGDC--VNVKSLDNRAGCYVLIEALRAIKASR-KKPS--CNFVAAFTVQEEVGLR--GAQAG------TLDIQPDFSIALDVTIAC------D---IPGTPAHDQ-VSHLGAGAAIKLYD-------GSVIADRRMVKFMKAMADANKIKWQTEM-LPAGGTDAGAMQKFVPGGSIAGAISVPTRNVHQVIEMAHKDDLDASVALLTACAMNVDKWDW-------  21
  22 -----FLTELLETPSPSGFEI-DAQRIWADELRK-----------YTE-DVQC-DTYGNTWAVFHA-DAEEAPTLMIEAHADEIGFMIRHITKDGFLYVERV-----GGTDTAIARGRRVRFLGSQ-GE-VMGVTGNTAIHL-REPGEK----E--PKIWEIYVDVGASSDKEVA-ELGLRVGHVGVYCDGPMLMNENK-LVCRALDNRLSGFILSEIARKLCKLK-KPVS--WNVVLVNAVQEEVGCI--GAGMI------THRLRPDAAICIDVTHAT------D---SPGLDKGKFGDIRLGGGPAV---I-------HGTANHPNLVARLEIVADKNKIPLQHEAAGRRTGTDTDSIY-ISRDGVASALVSVPLRYMHSPVETASLTDVENTIKLLLELVKSLMPGDSF------  22
  23 DARRTFLDELLAVHSPTGHEA-AAQRVWVEYVSQ-----------YAD-RVET-DAYGNAVAVAEG----GAPAVAFTGHADEIGFAVAEITEGGFVRIAPI-----GGLDASVTRGSQVRIETDD-GP-VNGVIGQAAVHL-RDHSED----GAAPSVTEQYVDIGAADGDDA--RDRVSVGDPGVLVSEPRELAGGR-LNARSLDNRTGLWVAAEGFRRAVE---RDVD--ATVYAVSTVHEEIGTR--GARMV------GFDLDVDAVVAADVTHAA------D---DPMYPAERASTVALGDGPVVM----------RGGTNHPVVVSALRDAAADAGASLQVAAHRISTGTDADAFG-TAGGGVPTADLGIPNRYMHTPAEVVDLADLAAGADVLAAFAAHAGDRDSFGVS---  23
  24 -----FLERLLLATGPSGFEE-EAAQVFLEKAST-----------FA--EAER-DRHGNVYARL---NPGQRPKVLLMGHLDEIGVIVSHVEEKGFLRLRPL-----GGWDPQVLVGQRLRFLGKK-GP-VLGVVGRKAIHV-LKEEER----KKAVEMAELFADIGAESREEAL-AY-LEVGAVGVLDQAPEWLLGKR-LVSKALDNRLGAFVVLEALRLLKD---RTP---CEVVAVGTAQEEIGAY--GARTA------AFREAPDLALVVDVHHDS------A---TPGMEKGLVGEAELGKGVVL---D-------VGPFVDKEVLRGLKAAAEREGIPYVLHAHGSHSGTDADEVA-KVREGIPTGIVSIPLRYMHSPVEMVDFRDVERAVRLLAAFVRGV------------  24
  25 PINRDFLFELLSQAAPSGAER-RAADVWKKEAAT-----------FA--RVSE-DHYGSVYAEL---GPENGPAIALMGHLDEIGLIVSHVDDKGHLSVLGV-----GGWDPQVLVGQRIRLLAPG-GD-LLGVVGKKAIHV-MEAEER----TKASKLEDLWIDVGL-DADEVK-AK-VPVGTYGVIEQGPV-MVGNK-VVSRALDNRVGAFIVLEALRALKD---VELK--HRIVAVGTSQEEIGVF--GAQTS------AYRLDPVAGIAVDVTHET------D---QPGVSEKKYGVAPFGSGANL---S-------VGPMTNPTLLRQLTEAAGRENIPYTLSASGRYTGTDADALT-LVRAGVPTGVVSIPNRYMHSPSEMVDERDVKACIDILAAWIRGLEETLEFTR----  25
  26 -----FLKRLLDTPGPSGFEG-APARAWRTEAAT-----------FTS-AIRA-DVIGNSYAVVEGTGGPNAPTILLAGHIDEIGVIITHIDDNGYIYFEPI-----GGWDPQVLVAQRMRFLGRN-GD-VFGVIGKKAIHL-MKPEER----EKASKITDLWVDIGVKNKAEAQ-EL-LQVGDAGVIDSRTMDMPNHR-IVSRSIDDRIGAFVVLEALRRYAE---NPGH--ARVVAAATAQEEIGYTGGGARVA------AHSQEATMAIAVDVTFAT------D---HPGVKKEEIGEHNIGGGPVL---T-------RGSVISPVVYRLLSETAQRLEIPFSIHAAGRFTSTDADAMQ-LARSGVATGLVSIPNRYMHSPNEMVSLEDLDRAATLIAETCRTVSDATDF------  26
  27 -----FLKRLLATPGPSGDED-QAARVWRAEART-----------FAD-QVYS-DVLGNSFAVLEGSG----PRILLAGHIDEIGLMISHIDDQGFLFFSPI-----GGWDAQVLVGQRVRLLGKN-GD-VIGVIGKKPIHL-LKPDER----NQATKIEQMWIDIGATSKSEAS-EL-VQVGDVGVIDAPVYELPGGR-IVSRSIDNRIGAFTVLEALRLLSQ---NRPN--AHVAAVATTQEEI--TFGGATTA------AFSFDPQIALVVDVTFAT------D---HPDSDQRQWNVVKLGGGPVL---S-------RGSANSGRVFRRLVELAEREAIPYSVQISPRYTGTDADAIH-HVRGGIASAVISIPNRYMHSPNEMIALHDVECAVRLIAAFVHSVSNVNEFI-----  27
  28 ---LDFLKKLLHSPAPSGYEG-PIQDVVREFAGE-----------FAD-EVTT-DLHGNVIAAVNP-KAER--RVMFAGHCDQIGLLVQYIDDDGYLWANLI-----GGWDIQMLLGQNMQVHTTS-GP-VHGVIARKAIHL-LTPDER----KTVPEIKDLWIDIGAKNGEEAR-KL-VAIGDPVTFELGFRPMLNNL-ASAPGMDNRVGVWVVMEALRQVSQ---KSPE--VGVFSVSTVQEEIGLR--GAKTS------AYSIQPEVGIAVDVTHAT------D---CPAVSKQENGDIKVGGGPVV---Y-------RGPNVNPVVFSSLKSLADEHEIDCQINGISRPAGNDANAMQ-LNQGGMATGIVAIPNRYMHSPVEVISLDDLEQAARLLAEFCLAINDQTDFTP----  28
  29 ---LEFFKKLVEAPSPSGYEQ-PAQRVFRDYIAP-----------FA--EVKT-DVMGNVIGLIRG-GGENLPRVMVVGHSDEIGFQVKYIDDNGFIYFAPI-----GGVDAHLTPGKRVRIHTAK-GE-VAGVIGKKPIHL-MDEEDR----RKVVRLDAQYIDIGATDKKEAL-EY-VRVGDPVTFAAGFERLLGDR-VACRAFDDKAGSFVVAEVLRAVAESGVKLP---VDLYGVSSVQEEIGLR--GGATS------AYSVNPHVGICVEVDFAT------D---QPDVEKKHNGEVKLGKGPIL---P-------RGANINPPLFDLLSSTAEREEIAVQYTGIPRASGTDANVMQ-ISRGGVATALVKLPLRYMHTPVEVISLSDLDQAVRLIVAAL---------------  29
  30 -----MLKALTDAKGIPGNER-EVRQVMKSYIEP-----------FAD-EVTT-DRLGSLIAKKTG--KENGPKIMISGHLDEVGFMVTQITDKGFLRFQTV-----GGWWSQVMLAQRVTVVTKK-GDIT-GIIGSKPPHI-LPP-DA-R--KKAADIKEMFIDIGASSREEAM-EWGVLPGDQVVPYFEFTVMNNEKHLLAKAWDNRIGCAIAIDVLKNLKN---SDHP--NEVYGVGTVQEEVGLR--GAKTA------AHTIQPDIAFGVDVGIAG------D---TPGISEKEA-QSKIGEGPQIILYD-------ASMVSHKGLRDLVVNTAEEAGIPYQFDS-IAGGGTDSGSIH-LTANGVPALSITIATRYIHTHAAILHRDDYENTVKLITEVIKK-------------  30
  31 -----MLKELTDAKGIPGNER-EVRQVMKSYIEP-----------FAD-DVTT-DRLGSLIAKKTG--LENGPKIMVAGHLDEVGFMVTQISDKGFLRFQTV-----GGWWSQVMLAQRVTVVTKK-GDIT-GVIGSKPPHI-LPP-EA-R--KKPVEIKDMFIDIGASSREEAM-EWGVLPGDQVVPYFEFTVMNNEKHLLAKAWDNRIGCAIAIDVLKGLQN---SDHP--NVVYGVGTVQEEVGLR--GAKTA------AHAIQPDIAFGVDVGIAG------D---TPGISEKEA-QSKMGKGPQIMLYD-------ASMISHKGLRDFVVNTAEEAGIPYQFES-LSGGGTDSGSIH-LTANGVPALSITIASRYIHTHAAMLHRDDYENAVKLITEVIKK-------------  31
  32 DETLTMLKDLTDAKGIPGNER-EVRQVMKSYIEP-----------FAD-EVTT-DRLGSLIAKKTG--AENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTV-----GGWWAQVMLAQRVTIVTKK-GEIT-GVIGSKPPHI-LSP-EA-R--KKSVEIKDMFIDIGASSREEAL-EWGVLPGDMIVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQN---TDHP--NIVYGVGTVQEEVGLR--GAKTA------AHTIQPDIAFGVDVGIAG------D---TPGISEKEA-QSKMGKGPQIIVYD-------ASMVSHKGLRDAVVATAEEAGIPYQFDA-IAGGGTDSGAIH-LTANGVPALSITIATRYIHTHAAMLHRDDYENAVKLITEVIKKLDRKTVDEITYQ-  32
  33 -----MLKELTDARGIAGNER-EPREVMKKYIEP-----------FAD-ELST-DNLGSLVAKKVG--EENGPKIMVAGHLDEVGFMITQIDDKGFLRFQTV-----GGWWSQVMLAQRVTIVTRK-GDVT-GVIGSKPPHI-LPP-EA-R--KKPVEIKDMFIDIGASSQEEAM-EWGVRPGDQVVPYFEFQVMKNEKMLLAKAWDNRIGCAIAIDVLKQLKD---EKHP--NVVYGVGTVQEEVGLR--GAKTS------ANYIKPDIAFAVDVGIAG------D---TPGVTAKEA-QSKMGDGPQIILYD-------ASVIGHTGLRDFVVDVADELQIPYQYDS-VAGGGTDAGAIH-ISANGIPSMAITIATRYIHSHAAMLHRDDYENAVKLIVEVIKRL------------  33
  34 ----KMLAALTDAKGIAGNES-EVRKVMTEYITP-----------FAD-EIST-DGLGSLIAKKTG--DENGPKIVVTGHMDEVGFMITQIDDKGFLRFQPV-----GGWWSQVMLAQRVTIVTGK-GDIT-GIIGSKPPHI-LSA-EA-R--KKPIDIKDMFIDIGASSKEEVK-EWGVKPGDMVVPYFEFTVMNNEKMLLAKAWDNRIGCAIAIDVLKQLKD---SDHP--NVVYGIGAVQEEVGLR--GSKTS------TFKIQPDIGFAVDVGIAG------D---TPGISEKEA-MSKMGEGPQIVIYD-------SSMVAHKGLRDFVTDTADEMNIPYQYES-IPGGGTDAGSIH-LTANGVPALAITIATRYIHSHAAMLHRDDYENAVKLIVEVIKR-------------  34
  35 -----MLIDLTSAKGIAGNED-EVRSLFKKYAAP-----------YAD-KFLY-DGLGSIIAKNVG--DKEGPKVYISGHMDEVGFMVTQITEKGFLKFQTV-----GGWWGQVMLAQQVQIKTTT-GKVYHGVIGSKPPHV-LTA-EV-R--NKPYEIADMFIDIGASSDQQVA-EWGIHPGDMVTPYIDYRRMNDTKFLLAKAWDNRIGTAVSLKVLENLAT---EGHP--NILFAGSDVQEEVGLR--GAQTS------THLVNPDIAFALDTGTAG------D---TPGMTPKEA-DSVLGEGPQILIYD-------ASMIPHKKLRDFVIQVAEENNIPFQYTV-ITGGGTDAGRMH-LTRNGIPSLAITVPVRYLHSHTSVIHEDDYFNTVKLVTEVVKR-------------  35
  36 -DLLNMLKEITEAPGVSGYEK-GIREVLKKYLSE-----------IA--VLEE-DRLGSLIFKKQG--SKETPKVMLAAHMDEIGFMVKSITSNGFIKFLPL-----GGWWDQVLLSQRVIIHTQN-GPIV-GVIGSKPPHI-LSE-EE-R--KKVVEKKDMYIDIGANSEEEAL-NWGVRPGDPITPYSEFQVMHNPDFLLAKAWDDRVGCALLVEIIKELKN---IDHP--NTIYGAATVQEEIGLR--GATTS------SFVVNPDVAIILESDIAT------D---VPGINE-EK-RIYLGKGPSIIIYD-------ATMIPNSNLRRIFIETAEKLNIPIQYSA-LERGGTDGGRIH-IHAKGVPSIVVGVPARYIHSHTSIINVKDFLNAKKLIVEVIKSLNKEIV-------  36
  37 -DLLNMLKEITEAPGVSGYEK-GIREVLKRYLSQ-----------IA--TLEE-DRLGSLIFKKEG--SNQRPKIMLAAHMDEIGFMVKSITSNGYIKFIPL-----GGWWDQVLLSQRVVIHTQN-GPII-GVIGSKPPHI-LSE-EE-R--KKVVEKKEMYIDIGASSEEEAL-KWGVRPGDPITPYSEFQVMHNPDLLLAKAWDDRVGCALLVEIIKELIN---ENHP--NTIYGVATVQEEVGLR--GATTS------SFVVNPDMAIILESDIAT------D---MPGINE-EK-KIYLGKGPSLIIYD-------ATMIPNSNLRRMFIDIAEKLNIPIQYSA-LERGGTDGGRIH-IHAKGVPSVVIGVPARYIHSHTSIINIQDFLNAKKLIIEVIKNLNEEIVEKL----  37
  38 DAMLQLLKDLTEAPGASGYES-PVRAVMRRYLEP-----------VG--EIEF-DHLGGIIARRTG--VSDGPRIALAAHLDEIGLLVTRITDDGFLKFQPL-----GGWWDHVLLGMRVDVITRQ-GA-IPGMIGAKPPHI-LGN-DE-R--SRLVDKKTMYIDIGATSREEAI-AWGVRPGDAVVPFGPLTPLRNPDLLMAKALDNRVGCAIVVETLRRLAT---EHHP--NIVFGIGNVQEEVGLR--GAATT------TYIVKPDIGLAIDTAIAG------D---TPGVGADDA-MSRLGQGPAMLLID-------GSLIAHSALRHLVIDVAAEEGIPLQFDL-MPGGGTDGGRMH-LFGSGVPTVVLGPPVRYIHSASAIVHRRDVEQTVQLLLALIRRLDDKTVQRLQYE-  38
  39 -----LFQTLTQLPGAPGNEH-QVRAFMKQELAK-----------YAD-DIVQ-DRLGSVFGVRRG--AEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTL-----GGWWSQVLLAQRVEIQTDN-GP-VPGVISSIPPHL-LTD-AQ-R--NRPMDIKNMMIDIGADDKEDAI-KIGIKPGQQIVPVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHG---KELP--NTLYAGATVQEEVGLR--GAQTA------SHMIKPDLFFALDASPAN------D---MSGDKN--E-FGQLGKGFLLRILD-------RTTVMHRGMREFVLDMAETHDIPYQY-F-VSGGGTDAGKVH-ISNSGVPSAVIGICSRYIHTNASIIHIDDYAAAKEMLIKLVTA-------------  39
  40 QETKALFQTLTQLPGAPGNEH-QVRAFMKQELAK-----------YAD-DIVQ-DRLGSVFGVRRG--AEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTL-----GGWWSQVLLAQRVEIQTDN-GP-VPGVISSIPPHL-LTD-AQ-R--NRPMDIKNMMIDIGADDKEDAI-KIGIRPGQQIVPVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHG---KELP--NTLYAGATVQEEVGLR--GAQTA------SHMIKPDLFFALDASPAN------D---MSGDKN--E-FGQLGKGFLLRILD-------RTTVMHRGMREFVLDMAETHDIPYQY-F-VSGGGTDAGKVH-ISNSGVPSAVIGICSRYIHTNATIIHIDDYAAAKEMLIKLVTACDKQTVDAIKEN-  40
  41 -----LFQTLTQLPGAPGNEH-QVRAFMKQELSK-----------YAD-DIVQ-DRLGSVFGVRKG--AEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTL-----GGWWSQVLLAQRVEVQTDK-GP-IPGVVASIPPHL-LTD-AQ-R--SKPMDIKNMMIDIGADDKEDAI-NLGIKPGQQIVPVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHG---KDVP--NNLYAGATVQEEVGLR--GAQTA------ANMIKPDLFFALDASPAN------D---MSGDKQ--Q-FGQLGKGFLLRILD-------RTTVMHRGMREFVLDTAETHDIPYQY-F-VSGGGTDAGRVH-ISNNGVPSAVIGICSRYIHTNASIIHIDDYAAAKEMLIKLVTA-------------  41
  42 -----LFRTLTQLPGAPGNEH-QVRSFMKRELAK-----------YAD-DIVQ-DRLGSVFGVRRG--AEDAPTVMVAGHMDEVGFMVTQITDNGMLRFQTL-----GGWWSQVLLAQRVEVQTDN-GP-VIGVISSIPPHI-LTD-AQ-R--AKPMEIKNMMIDIGTDDKEDAV-RMGIRPGQQVVPVCPFTPMANEKKILSKAWDNRYGCGLSIELLKELHG---KELP--NNLYAGATVQEEVGLR--GAQTA------ANMIQPDLFFALDASPAN------D---MSGDKE--L-FGRLGEGVLLRILD-------RTTVMHRGMREFVLDMAETHNIPYQY-F-ASGGGTDAGRVH-ISNSGVPSAVIGICSRYIHTNAAIIHVDDYAAAKEMLIKLVMA-------------  42
  43 ---LELFRTLTELQGTSGFEH-DVRRFMKQELSK-----------YAD-EIVQ-DGLGSVFGLKKG--DENGPRVLVAGHMDEVGFMVTQITKNGMIRFQTL-----GGWWSQVLLAQRVQIMTKN-GP-IVGVVGSIPPHL-LSD-AQ-R--AKPMDIKNMLIDIGADSYEDAL-EIGVKPGQQIVPICPFTPMANEKKIMAKAWDNRYGCGLAIELLKELKD---EKLP--NTLYSGATVQEEVGLR--GAQTA------ANMIQPDIFYALDASPAN------D---ASGDKT--Q-FGQLGKGALLRIYD-------RTMVTHRGMREFILDTAETHNIPYQY-F-ISQGGTDAGRVH-TSNSGIPSAVIGVCARYIHTHASILHVDDYAAAKELITKLVRATDKTTLETIKN--  43
  44 DELVSFFSRLSESFGPSGFES-EPINLIKERYSI-----------FSE-SSIR-DGLGSLIFKKSG--ETEGPKVMAAGHVDEIGFIIVSIEDNGFLKFETL-----GGWASTTLPAQRVIVRTKR-GDHV-GVITSKPPHL-MTP-EE-R--NKPIEIKDLFIDVGAKNKDQVK-EMGIRIGDPVAPLAPFEVLRGGKAWLGKAFDDRVGTLVVMEVLRNLKEGG-VNHP--NTYYAVATVQEEVGLR--GAETA------ADVVNPDVFIAVDVDIAG------D---SPGITSAEA-PAKMGEGVSIITWD-------RSMIPNFKLREFVIEVAEEENIPYQLSA-V-RGGTDAGRVH-LHSKGVPSVVLGIPTRHIHSHSSILSPDDVEATMKLLLALIRKMDSKVVR------  44
  45 ----DLLKKFSEAHGISGHED-EVRSLVAQELEG-----------YG--EFSS-DGSGSLFC--TG--GEAGPRVMLAAHMDEIGFLVQNIASNGFLQLVGI-----GGWWPHTLLSQRVLVKTRS-GRGIRGVIGSKPPHF-LPE-SQ-R--NSVMSMEALFVDVGAESAEQVKNEFGIHLGDPVVPDVRFSPLENPFRVMGKAFDNRAGLSVMIEAFKKLCR---EGHP--NTLIAAATVQEEVGTR--GARTA------GVAMQPDCVIVLEGPPAD------D---TPGFAVTDS-QGALGGGVQIRLFD-------PTAITNPRLAALAEKTALDAGIPFQLTV-RRSGGTDAAALH-LSGKGVPTIVLGIPTRYIHAHNGVLDLRDYRAAVELTVALARSLDQEAVEALTHY-  45
  46 ------LQQLCEASAVRGDEQ-EVRDILINTLEP-----------CVN-EIAF-DGLGSFVARK----GNKGPKVAVVGHMDEVGFMVTHIDESGFLRFTTI-----GGWWNQSMLNHRVTIRTHK-GVKIPGVIGSVAPHA-LTE--K----QQPLSFDEMFIDIGANSREEAK-KRGAEIGDFISPEANFACWGEDK-IVGKALDNRIGCAMMAELLQTVNN-----PG--ITLYGVGSVEEEVGLR--GAQTS------AEHTKPDVVIVLDTAVAG------D---VPGIDNIKY-PLKLGNGPGLMLFD-------KRYLPNQKLVAALKNCAAHNGLPLQFST-MKTGATDGGRYN-VMGGGRPVVALCLPTRYLHANSGMISKADYDALLTLIRDFLTTLTAEKVNAFSQF-  46
  47 ------LQQLCEASAVSGDEQ-EVRDILINTLEP-----------CVN-EITF-DGLGSFVARK----GNKGPKVAVVGHMDEVGFMVTHIDESGFLRFTTI-----GGWWNQSMLNHRVTIRTHK-GFKIPGVIGSVAPHA-LTEKQK----QQPLSFDEMFIDIGANSREEAE-KRGVEIGDFISPEANFACWGEDK-VVGKALDNRIGCAMMAELLQTVNN-----PE--ITLYGVGSVEEEVGLR--GAQTS------AEHIKPDVVIVLDTAVAG------D---VPGIDNIKY-PLKLGQGPGLMLFD-------KRYFPNQKLVAVLKNCAAHNDLPLQFST-MKTGATDGGRYN-VMGGGRPVVALCLPTRYLHANSGMISKADYDALLTLIRDFLTTLTAEKVNAFSQF-  47
  48 ----ELLQQLCEASAVSGDEQ-EVRTLLINALES-----------SVD-EITF-DGLGSFVARK----GNRGPKVAVVGHMDEVGFMVTHIDESGFLRFTTI-----GGWWSQSMLNHRVTIRTRK-GFKIPGIIGSVAPHA-LTEKQK----QQPLTFDEMFIDIGANSHEEVE-KYGIAIGDFISPEANFARWGEDK-IVGKALDNRVGCALMAELLQTVDN-----PD--ITLYGVGSVEEEVGLR--GAQTS------AEHIKPDVVIVLDTAVAG------D---VPGIDAIKY-PLKLGDGPGLMLFD-------KRYFPNQQLVAALKACAKNSDAPLQFCT-MKTGATDGGRYN-VMGGGRPVAALCLPTRYLHANSGMISAADYDALFTLVRELLSS-------------  48
  49 ------IKEVTEIAAVSGHEA-PVRNYLRKKITP-----------HVD-EVIT-DGLGGIFGVKHS-EATNAPRVLVAAHMDEVGFMVSEIKPDGTFRVVQI-----GGWNPLVVSSQRFKLSNRT-GDEIPVISGSVPPHL-TRG-TG-G--PSLPRIEDIVFDGGFADKAEAE-SYGIRPGDTIVPDSSAILTANGKNVISKAWDNRYGVLMVSELVQALAG---QKLN--NELYVGANVQEEVGLR--GAHVS------TTKFDPEVFLAVDCSPAG------D---IY---G--D-QGAIGEGTLIRFFD-------PGHLMLPNMKDFLLTTAEEAGIKYQY-Y-CGKGGTDAGAAH-LKNGGVPSTTIGVCARYIHSHQTLYAMDDFLQA-QAFLQALVKK------------  49
  50 MELFDKVKALTEIQATSGFEG-PVRDYLKARMVE-----------LGY-QPEF-DGLGGIFVTKAS-KVENAPRIMVAAHMDEVGFMVSSIKADGTFRVVPL-----GGWNPLVVSGQRFTLFTRT-GKKIPVVTGGLPPHL-LRG-TGVT--PQIPAISDIIFDGAFENAAEAA-EFGIAQGDLIIPETETILSANGKNIISKAWDNRYGCLMILELLEFLAD---KELP--VTLIIGANVQEEVGLR--GAKVS------TTKFNPDLFFAVDCSPAS------D---TF---G-DD-NGRLGEGTTLRFFD-------PGHIMLPGMKNFLLDTANHAKVKTQV-Y-MAKGGTDAGAAH-LANGGVPSTTIGVVARYIHSHQTIFNIDDFLQA-QTFLRAIITSLNTEKVAEIKNY  50
  51 ------IKELTELQGTSGFED-DIRAYMKEHITP-----------LVD-DVQY-DGLGGIFGIKRS-KVEAAPRVMVAAHMDEVGFMLTQINDNGLFQVVPL-----GGWNPYVVSAQRFTLKTSK-GN-YPCISSSIPPHL-LRG-TS-G--QKQLEVSDVLFDAGFSSKEEAE-SFGVRPGDSIVPQTETIKTANGKNIISKSWDNRYGCTLVLDALETLQN---EELG--HTLIAGANVQEEVGLR--GSKPS------VHKFNPDIFFAVDCSAAD------D---IHTKKG--T-YGHLGEGTLLRIFD-------PGLITLPRLREYLLDTAATHNIPYQY-F-VSKGGTDAGAAH-TTNNGVPSTVIGVCGRYIHTHQTMFSIADYEAAREMLLQALR--------------  51
  52 ----QLIQELSNANGVSGFET-EVVRILQHATAD-----------FT--IQRL-DAIKNLYLEKKN-NLSEGPVVLFDAHSDEVGFMIQAIKENGLLRFLPL-----GGWVPNTISAQKVRIRNRE-GTYLPGVVTSRPPHF-MTPEER----QRPLTIADLTIDIGATSKEEVIETYKIDLGAPVIPDVTCCYNEQTELFLGKAFDCRIGCACLVDVMEELKE---ETLP--FKLVATVTAQEEVGER--GALIA------AKQVNPDLAIVFEGCPAD------DTAETPEMI-----QSAMGKGPMLRYFD-------VSMITNPEFQEYALEIAKINKIPVQVSV-RSGGGTNGMAI--TQVQGAPTIVVGIPVRYAHTPHCYVDFQDYQAAKELVIQLIKN-------------  52
  53 -MDLSLLKALSEADAIASSEQ-EVRQILLEEADR-----------LQK-EVRF-DGLGSVLIRLNE---STGPKVMICAHMDEVGFMVRSISREGAIDVLPV-----GNVRMAARQLQPVRITTRE-ECKIPGLLDGD---------------RQGNDVSAMRVDIGARSYDEVM-QAGIRPGDRVTFDTTFQVLPHQR-VMGKAFDDRLGCYLLVTLLRELHD---AELP--AEVWLVASSSEEVGLR--GGQTA------TSAVSPDVAIVLDTACWA-KNF--D-------YGAAN-HRQIGNGPMLVLSD-------KSLIAPPKLTAWIETVAAEIGVPLQADM-FSNGGTDGGAVH-LTGTGVPTVVMGPATRHGHCAASIADCRDILQMEQLLSALIQRLTRETVVQLTD--  53
  54 ------LKALSEADAIASSEQ-EVRQILLEEADR-----------LQK-EVRF-DGLGSVLIRLNE---STGPKVMICAHMDEVGFMVRSISREGAIDVLPV-----GNVRMAARQLQPVRITTRE-ECKIPGLLDGD---------------RQGNDVSAMRVDIGARSYDEVM-QAGIRPGDRVTFDTTFQVLPHQR-VMGKAFDDRLGCYLLVTLLRELHD---AELP--AEVWLVASSSEEVGLR--GGQTA------TRAVSPDVAIVLDTACWA-KNF--D-------YGAAN-HRQIGNGPMLVLSD-------KSLIAPPKLTAWIETVAAEISVPLQADM-FSNGGTDGGAVH-LTGTGVPTVVMGPATRHGHCAASIADCRDILQMQQLLSALIQRLTRETVVQLTDF-  54
  55 -MDLSLLKALSEADAIASSEQ-EVRQILLEEAAR-----------LQK-EVRF-DGLGSVLIRLNE---STGPKVMICAHMDEVGFMVRSISREGAIDVLPV-----GNVRMAARQLQPVRITTRE-ECKIPGLLDGD---------------RQGNDVSAMRVDIGARTYDEVM-QAGIRPGDRVTFDTTFQVLPHQR-VMGKAFDDRLSCYLLVTLLRELHD---AELP--AEVWLVASSSEEVGLR--GGQTA------TRAVSPDVAIVLDTACWA-KNF--D-------YGAAN-HRQIGNGPMLVLSD-------KSLIAPPKLTAWIETVAAEIGVPLQADM-FSNGGTDGGAVH-LTGTGVPTLVMGPATRHGHCAASIADCRDILQMEQLLSALIQRLTRETVVQLTD--  55
  56 FSVQETLFSLLQHNAISGHEN-AVADVMLCEFRR-----------QAK-EVWR-DRLGNVVARYGS-DKPDALRLMIFAHMDEVGFMVRKIEPSGFLRFERV-----GGPAQVTMAGSIVTLTGDK-GP-VMGCIGIKSYHF-AKGDER----TQSPSVDKLWIDIGAKDKDDAI-RMGIQVGTPVTLYNPPQLLANDL-VCSKALDDRLGCTALLGVADAIST---MELD--IAVYLVASVQEEFNIR--GIVPV------LRRVKPDLAIGIDITPSC------D---TPDLHDYS--EVRINQGVGITCLNYHGRGTLAGLITPPRLIRMLEQTALEHNIPVQREV-APGVITETGYIQ-VEQDGIPCASLSIPCRYTHSPAEVASLRDLTDCIRLLTALAGMSAAHFPVEPDSG-  56
  57 --VYKTLEELVSLPGPVGHEY-IVSNWLKKRWIN-----------KSE-ECFE-DKVGNLICKIGG----KGPKLLIQAHMDEIGFIVRYITPDGFLLIDPVQEAHRSGPNHLHMIGQLAQVISRT-GEVATGIFATSTGHV-LTEQQM----AGNLNFNSLFIDMGVNSKEEVE-KLGVHIGSSVVWKRELTQVGNK--LIGKAFDDRIGLLVMALLLEKMDV---SNLN--YEVWYGATVQEENKAH--GAYAL------GSRMDFDMAISLDIGLVG------D---IPTVNEQDY-PTRLGGGPTLVYKD-------GAIHYNPKITWGLEDISKKYNIPYQIGI-YSNYGSDGIA---LFDSGIPAALIGIPTRYTHTPFEMVDIKDIYSTVNLLNHFIEN-------------  57
  58 ---KELLKELSLSHAPSSRED-KLYDLIKDKFSV-----------FG--KVTI-DSMNNIIIHKEG---HGRGKVMVMAHADEIFLIVTEILSNGVVKFKGV------GVDPKSLVSQEIIIHGRK-D--ILGIVNTIKDT------------NKAVTLNDLIIDTGYS--KENL-EKIIKIGDFITIKGKFIELLNNN-IACKTIDNRGSIVAMYQCAKELQN---IHHD--LDVYFVCSCQEEVGHR--GAKMA------TYNLNPDIGIAIDTTF--------D---SGELGAKDR-ENIIGNGPII---C-------LGPNLHHKLNRNIMFIGDKYGIPYGVEVEPGNTGTDAWDIQ-VSKKGVPSMLVSIPIKHMHTPVELVNMNDIENTGKIIARFIENL------------  58
  59 MENKELLKALSLAHAPSSRED-KLYTLIKEKFSV-----------FG--EVTI-DSMNNIIIHKEG---NSRGKVMVMAHADEIFLLVTEILNNGVLKFKGV------GVDPKSLVAQEVVIHGTK-D--ILGIVNIGKGI------------NKAVNSNDLIIDTGYN--KESL-EKIIKIGDFITIKGKFVELLNSN-VACKTIDNRGSIVAMYQCAKELQN---IQHD--LDVYFVCSCQEEVGHR--GAKMA------TYNLNPDIGIAIDTTF--------D---SGELGAKDR-ENIIGNGPVI---C-------HGPNLHHKLNKKITSIGDKYGIPYGIEVEPGNTGTDAWDIQ-VSRKGVPSMLVSIPIKHMHTPVELVNMNDIKNTGKIIARFIENLKENELEELLC--  59
  60 ---KELLKKLTLAHAPSSRED-KLYSLIKDNFSE-----------FG--KVTI-DEMNNIIVHKKG---TKKGSIMIMAHADEIFLIVNDILENGTLKFKGV------GVDPKAIVGREVTIHGKE-D--ILGVINTSKDT------------DKAVTADDLAIETGYS--KENI-EKIVRIGDFVTINGKFVELLNNE-IACKTIDNRGSIVSMYQCAKELQN---IEHD--LDVYFVCSCQEEVGHR--GAKMV------TYNLNPDIGIAIDTTF--------D---SGALGTHDR-ENVIGNGPVI---C-------HGPNLHHKLNKKIIEIGDKYKIPYGVEVEPGNTGTDAWDIQ-VTREGVPSMLVSIPIKYMHTPVELVSMDDINNTGKIIAKLIENL------------  60
  61 MDNKELLKKLTLAHAPSSRED-KLYSLIKENFSD-----------FG--EVTI-DDMNNIIIHKKG---TKKGSIMIMAHADEIFLIVNEILEDGILKFKGV------GVDPKAIVSTEVTIHGKK-D--ILGIISVTKDT------------DKAVTADDLVIETGYS--KEAL-EKIVHIGDFVTIKGKFVELLNNE-IACKTIDNRGSIVSMYQCAKELQN---IEHD--LDVYFVCSCQEEVGHR--GAKMV------TYNLNPDIGIAIDTTF--------D---SGALGTHDR-ENIIGNGPVI---C-------HGPNLHHKLNKKIIEIGDKYKIPYGVEVEPGNTGTDAWDIQ-VARQGVPSMLVSIPIKHMHTPVELVSMDDIKNTGTIIAKLIENLKSDDLEELLC--  61
  62 -----LLRNLTENFAPTGSER-SIFPVIESALKG-----------YID-EIKVHEPSNSLIGFKKG---TGKCALMLEAHVDEVVMVVSNLEKNGFLKVTSR------SIDPKILPGSEVIIHGKK-R--IKGVIGVKPYHL-VKEGDE----NVAYDFNKLFVDTGLSESEI---RDLVSVGDYVTFAPNFDKIGNY--FVNKSFDNRLGVYVLIETARVLKN---IRHD--VNVYFLFSSQEEFTGL--GAITA------TFSIFPSASVVIDVTFGT-QYRITS-----------SDGFELGKGPAIF----------YGISVNRDLTDKLSSVANKYGIPYQKEV-GVLSSTDADKIS-LVRSGIPVTLISIPIRYMHTPIEMFDPFDVDKTVQILKLFIEEFK-----------  62
  63 ---MQLLKELCSIHAPSGNEE-PLKDFILEYIRSNAGSWSYQPVIYAD------NDLQDCIVLVFGN-----PRTAVFAHMDSIGFTVSYNN-----HLHPI-----GS--PSAKEGYRLVGKDSN-GD-IEGVLKIVDEEWMLET------------------------------DRLIDRGTEVTFKPDFREEGDF--ILTPYLDDRLGVWTALELAKTLEH-----------GIIAFTCWEEHG----GGSVAYLARWIYETFHVKQSLICDITWVT------E-------------GVEAGKGVAISMRD--------RMIPRKKYVNRIIELARQTDIPFQLEV-EGAGASDGRELQ-LSPYPWDWCFIGAPEKDAHTPNECVHKKDIESMVGLYKYLMEK-------------  63
  64 ---MELIKELVSIPSPTGNTY-EVINYIESLLKE-----------WKV-ETVR-NHKGGLIATLPG--RDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLI-----GGFRYNSIEGEYCQIETAS-GKTYTGTILMHQTSV-HVY-KDAGKAERNQENMEIRLDEPVHCRKDTE-ELGIGVGDFVSFDPRVEITSSGF-IKSRHLDDKASVALLLRLIHEIQTED-IELP--YTTHFLISNNEEIGY---GGNSN------IPPETVEY-LAVDMGAIG-DGQATD-----------------EYSVSICVKD-------ASGPYHYQLRKHLVQLAEKHHIDYKLDI-YPYYGSDASAAI-KSGHDIVHGLIGPGIDASHA-FERTHKSSLRHTAKLLYYYVQSPM-----------  64
  65 RKTMELIKELVSIPSPTGNTY-EVINYIESLLKE-----------WKV-ETVR-NHKGGLIATLPG--RDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLI-----GGFRYNSIEGEYCQIETAS-GKMYTGTILMHQTSV-HVY-KDAGKAERNQENMEIRLDEPVHCRKDTE-ELGIGVGDFVSFDPRVEITSSGF-IKSRHLDDKASVALLLRLIHEIQTED-IELP--YTTHFLISNNEEIGY---GGNSN------IPPETVEY-LAVDMGAIG-DGQATD-----------------EYSVSICVKD-------ASGPYHYQLRKHLVQLAEKHHIDYKLDI-YPYYGSDASAAI-KSGHDIVHGLIGPGIDASHA-FERTHKSSLRHTAKLLYYYVQSPMV----------  65
  66 ----KLIKELVQIPSPTGNTF-EVIAYIESLLKE-----------WKV-ETIR-NHKGGLIATLPG--RNEERQRMLTAHVDTLGAMVKEIKADGRLKIDLI-----GGFRYNSIEGEYCQIETSS-GKTYTGTILMHQTSV-HVY-KDAGKAERNQENMEIRLDEPVRSRRDTE-ELGIGVGDFVSFDPRVEVTPSGF-IKSRHLDDKASVALLLQLIRQIKTEE-IELP--YTTHFLISNNEEIGY---GGNSN------IPAETVEY-LAVDMGAIG-DGQATD-----------------EYTVSICVKD-------ASGPYHYQLRKHLTELAEKHGIEYKLDI-YPYYGSDASAAI-KSGHDIVHGLIGPGIDASHA-FERTHESSLRHTAKLLYYYVQSPM-----------  66
  67 ---MELIKKLVSIPSPTGNTY-EVIAYTESLLKD-----------WGV-SSYR-NRKGGLFVTIPG--RDDKKHRLLTAHVDTLGAMVKEIKADGRLKIDLI-----GGFRYNSIEGEYCEIQTSS-GKTYTGTILMHQTSV-HVY-KDAGKAERNQENMEVRLDEHVRTKEETS-DLGIRVGDFISFDPRVQITPSGF-IKSRHLDDKASVALLLDLIRRITEEK-IDLP--YTTHFLISNNEEIGY---GGNSN------IPPETVEY-LAVDMGAIG-DGQSTD-----------------EYTVSICVKD-------ASGPYHYQLRKHLAGLAERYGIDYQLDI-YPYYGSDASAAI-RSGHDIVHGLIGPGIDASHA-FERTHELSLLNTAKLLHRYVLSP------------  67
  68 ---MELIKELVSIPSPSGNTA-KIIKFIENYVSE-----------WNV-ETKR-NHKGALIVTVKG--KNDDQHRLLTAHVDTLGAMVKEIKPDGRLRLSMI-----GGFRWNSVEGEYCEIETSS-GKTYTGTILMHQTSV-HVY-KNAGEAKRDEQNIEVRIDERVSSANEVR-ELGIEVGDFVSFDPRVQITESGY-IKSRHLDDKVSVAILLKLIKRLQDEK-VTLP--YTTHFLISNNEEIGY---GGNSN------IPEETVEY-LAVDMGALG-DGQASD-----------------EYTVSICAKD-------SSGPYHYALRKHLVELAKANSIEYKVDI-YPYYGSDASAAI-RAGFDVKHALIGAGIDSSHA-FERTHENSIAHTEALVYAYVM--------------  68
  69 KETMELIKELVSIPSPSGNTE-KIIRFIENYVSE-----------WNV-ETKR-NNKGALILTVKG--KNDAQHRLLTAHVDTLGAMVKEIKPDGRLSLSMI-----GGFRWNSVEGEYCEIETSS-GKTYTGTILMHQTSV-HVY-KDAGEAKRDEKNIEVRIDERVFSADEVR-KLGIEVGDFVSFDPRVQITESGY-IKSRHLDDKVSVAILLKLIKRLQDEN-VTLP--YTTHFLISNNEEIGY---GGNSN------IPEETVEY-LAVDMGALG-DGQASD-----------------EYTVSICAKD-------SSGPYHYALRKHLVELAKTNNIEYKVDI-YPYYGSDASAAI-RAGFDVKHALIGAGIDSSHA-FERTHESSIAHTEALVYAYVLSEMI----------  69
  70 KETMELIKQLVSIPSPSGNTG-KIISFIENYVKE-----------WNV-ETKR-NHKGALILTLKG--KNELRHRLVTAHVDTLGAMVKEIKADGRLRLSMI-----GGFRWNSVEGEYCEIETSS-GKTYTGTILMHQTSV-HVY-KDAGEAKRDEKNIEVRIDERVSSADEVR-ALGIEVGNFVSFDPRVQITESGY-IKSRHLDDKVSVGILLQLIKRLQEEK-VILP--YTTHFLISNNEEIGY---GGNSN------IPEETVEY-LAVDMGALG-DGQASD-----------------EYTVSICAKD-------SSGPYHYGLRKHLVELAKENKIEYKVDI-YPYYGSDASAAI-RAGFDIKHALIGAGIDSSHA-FERTHESSIAHTEALVYAYVLSPMVGE--------  70
  71 MSTLKYLEKLIEIPSPTGYTR-EVTEYIVKEVRD-----------MGY-EAVK-TNKGGVIVTLKG--KDDTKHRAITAHVDTLGAIVRAVKSDGRLKMDKI-----GGFPWNMIEGENCLVHVASTGKTVSGTILIHQTST-HVY-RDAGTAERTQDNMEVRLDEKVESKEETK-ALGIEVGDFISFDPRMTITESGF-VKSRFLDDKVSVAILLNLLKIYKKEN-IELP--NTTHFMFSCFEEVGH---GANSS------IPAEVTEY-LAVDMGAMG-DDQQTD-----------------EYTVSICVKD-------ASGPYNYEFRQHLVKLAKENNIPFKLDI-YPYYGSDASSAM-RAGAEVKHALLGAGIESSHS-YE---------------------------------  71
  72 ------MENLLDIPSPTGYTE-KAIYYIKNQLDI-----------IKV-PYKE-TTKGALIVTLKG--DNDSYQRTFSAHIDTLGAMVKEIKSNGNLSLTLI-----GGFMCNSVEGENCTIFTLE-NKKYSGTIQTIKPSV-HISGDDARNLKRSEENMEVILDEKVFSKEDVL-NLGINVGDFIAFDPRTTITKNGF-IKSRHLDDKASAAILLYTINHIIDSN-MSLP--YTTNFFFSNYEEVGH---GASAC------IPNNTKEF-ISVDMGAPG-LNQNSS-----------------EYSVCICAKD-------SSGPYDYNLRKKLITLCEKNNINYKIDI-YPHYGSDASAAL-RAGWDLKTALIGPGVFASHA-YERTHIDSIISTLNLVLQYCL--------------  72
  73 ---MNYMENLLTIPSPTGYTE-NVMDYVKKQLDL-----------VKV-PYKE-TNKGAIIVSLKG--NNDSYQRTFSAHIDTLGAMVKEIKSNGKLSLTLV-----GGFMCNSIEGENCTILTLE-NKKYSGTIQTIKPSV-HISGDDARNLKRNEENMEVILDEKVFSKEDVL-NLGINVGDFIAFDPRTTITENGF-IKSRHLDDKASAAILLYTINHIINNN-INLP--YTINFFFSNYEEVGH---GASAC------IPDNTKEF-ISVDMGAPG-LNQNSS-----------------EYSVCICAKD-------SSGPYDYSLRKTLINLCQKNNIDYKIDI-YPHYGSDASAAL-RAGWDLKTALIGPGVFASHA-YERTHMDSIISTLNLVLQYC---------------  73
  74 ----NYMQNLLSEPSPTGYTE-DVLNYVKEQLNL-----------LKA-PYIV-TNKGAVIVSLKG--ENQDYERTFSAHIDTLGAMVKEIKSNGTLGITLI-----GGYMCNSIEGENCTVLTLD-DKKYSGTIQTIKPSV-HISGDDARNLTRSEENMELILDEKVFSKEDVL-NLGINVGDFIALDPRTTITENGF-IKSRHLDDKASAAILLYTIEYIITNN-IELP--YTTNFFFSNYEEVGH---GASAC------VPDKTKEF-ISVDMGAPG-LNQNSS-----------------EYSVCICAKD-------SSGPYDYSLRKTLVNLCKEKNIDFKIDI-YPHYGSDASAAL-RAGHDIKTALIGPGVFASHA-YERTHVDSVISTLSLILSYCQT-------------  74
  75 -----YMENLLNISSPTGYTE-DVLNYVKKQLNL-----------LKA-PYIV-TNKGAVIVSLKG--KNEDYERTFSAHIDTLGAMVKEIKSNGKLGITLI-----GGYMCNSIEGENCTVITLD-DKKYSGTIQTTKPSV-HISGDDARNLTRSEENMELILDEKVFSKENIT-ELGINVGDFVALDPRTIITENGF-IKSRHLDDKASAAILLYTIEYLIDNN-IELP--YTTNFFFSNYEEVGH---GASAC------VSEKTKEF-ISVDMGAPG-LNQNSS-----------------EYSVCICAKD-------SSGPYDYSLRKILVNLCKEKNIDYKIDI-YPHYGSDASAAL-RAGHDIKTALIGPGVFASHA-YERTHIDSVISTLNLVLSYCQ--------------  75
  76 -----YLKNILTIPSPTGFTN-HITNYLKKELDT-----------IGI-EYKI-TNKGSIIITLEG--EDKSFERTLSAHMDTLGAMVKDINDNGTLSIVPL-----GGFMMNSIEGENCSIHTLN-DEVYSGTIQTIKPSV-HIHGKEAYDLKRSPENMEVILDEKIFSKKDIE-NLNINIGDFISFDTRNIFTENGF-IKSRHLDDKASLAILLYAIKYIHVNN-LPLS--CTTNFLFSNYEEVGH---GASY-------IPKNTKEF-IAVDMGAPG-ENQNSS-----------------EYSVCICAKD-------STGPYDLDFRKKLINICKTSNIPYKIDI-YPSYGSDASAAL-KAGFDIKAALIGPGVYASHA-YERTHMDSILATLDLIIKYCVS-------------  76
  77 ----NLLEELLNIYSPTGDTE-DAIRFMEEKFKE-----------LNI-PTRR-TNKNALIATIEG--EEKE-AITFSGHVDTLGLMVKEIKANGRLAFSLV-----GGFSPTSVETENVFIKTYD-GKLIPGTALYNEASV-HVY-DTTTTATRSIKNMEIRIDEDVKTAEDVK-KLGISVGDFICLDPRCRIYESGF-IKSRHLDDKACIASMMGLAKHIVENK-IKPK--NTINFFISNYEEIGH---GSSF-------IPENTVEF-FAVDMAAPG-VGQESD-----------------EKAVTICAMD-------SSTPYDLGMRNKLRAIAEKNNIDYRIDI-YPHYGSDATAAL-RAGHDIRCALIGPGVDASHS-YERTHILGIENTYRLMLEYL---------------  77
  78 DYILKTAKEILEFNSPTGFCF-DIMKKIEEIAKG-----------FGY-KFET-TRKGCGIITVKG--QSDEEVIGLSAHVDTLGAMVRSITSDGKLKFTLL-----GGPIVPTLDGEYCIIRNRE-GKLYSGTFLSTSPAA-HVF-EDSSSKTREPKNMEIRIDEVVKSKEDVE-KLGICAGDFVFIDPKTTITESGF-IKSRFIDDKGSVSCLMGLLELFNREN-IIPK--FTTKIFISVYEEVGH---GSSY-------IPKDITEM-IAVDMGCIG-DDLNCT-----------------EYDVSICAKD-------SGGPYDYNMTTKLVNLAKENDINYAVDI-YPMYGSDVGAAL-KGGNDIRGALIGPGVHASHG-MERTHYNAFENTIKLLYFYLT--------------  78
  79 -------KELIEIPSVGGDCR-RAMNRVRDEFTA-----------LGL-KPKE-TNKGALIASQPG--RTQNGGRIVSAHVDTLGAVVRRIEPNGTLRLLTV-----GGFSWNCVEAENLLVHTAD-GKTVEGSLMPDKASR-HAFAEEVTTMVRDDDHVHVRLDEPVQTAEDVR-RLGIEVGDIVSFETRFRRTPAGF-VKSRYLDDKICLACCFGAIKALKDAS-LLPS--RPVHWYASNYEEIGH---GVSV-------IPDGVTEC-LAVDIAIVA-EGNNSS-----------------ERAVSILAKD-------SRTPYPVDFRHRLQKLAQAEGIPYRVDT-PYRYGSDASMGA-LAGFDFNFAAMGPGVDASHH-YERTHIDALKATCGLLMAYL---------------  79
  80 --------ELINIPSPVGYTH-NAIEWVKNELKK-----------LGI-KNYNITKKGALIAYIKG--EDSNYKKMISAHVDTLGAVVKKIKKNGRLEVTNV-----GGFAWGSVEGENVTIHTIS-GKTYSGTLLPIKASV-HVYGDVAREMPRTEETMEIRIDEEVKSDGDVL-KLGILQGDFVSFETRTRILDNGY-IKSRYLDDKLCVAQILSYIKYLKDNK-LKPK--TDLYIYFSNYEEIGH---GVSV-------FPEDLDEF-IAVDIGLVAGEDAHGD-----------------EKKVQIIAKD-------SRSPYDFTLRKKLQETANKNNIKYTVGV-YNRYGSDATTAI-LQGFDFKYACIGPNVDATHH-YERCHNDGIVETVKLLIAYL---------------  80
  81 DYTLDVLLRLLATPSPTGFTE-AALALVEGELHK-----------LSV-PSQR-TRKGALTWEVPG--SG-AGHVTYSGHVDTLGAMVKAIKPNGRLLLWPL-----GGYDWATVEGEDVLVHRQN-GETVSGTVVNVRQST-HVHGAALRDLRREAAVMEVRLDAVTGSAAETR-GLGIGVGDFVSFDARPRLTPAGY-VKARHLDNKAAVAVFLTVTRAL-----LQSPPVKTVAFHVTTYEEVGH---GAATG------IPPHTDEL-IAVDMAAVG-DGQTSS-----------------EHHVTLCVAD-------GGGPYDHALGNRLRAAAARAGVELRVDI-YPFYSSDGTAAW-RAGGDYPVALIGPGVDASHA-YERTHTDALDATAALMLAYVGA-------------  81

     Active site residue:           X

     Metal binding site:            X

     Putative:              +

     Experimental:          #