Structure of interleukin 11 (gp130 P496L mutant).
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8qy4
Q-score: 0.404
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Il-11 signalling complex (Complex from Homo sapiens)
- Interleukin-11 receptor subunit alpha (45 kDa, Protein from Homo sapiens)
- Interleukin-11 (21 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (102 kDa, Protein from Mus musculus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8qy5
Q-score: 0.358
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 receptor subunit alpha (51 kDa, Protein from Homo sapiens)
- Interleukin-6 (23 kDa, Protein from Homo sapiens)
- Il-6 signalling complex (Complex from Homo sapiens)
- Interleukin-6 receptor subunit beta (102 kDa, Protein from Mus musculus)
Structure of interleukin 6 (gp130 P496L mutant).
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 8qy6
Q-score: 0.361
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 receptor subunit alpha (51 kDa, Protein from Homo sapiens)
- Interleukin-6 (23 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (102 kDa, Protein from Mus musculus)
- Il-6 signalling complex (Complex from Homo sapiens)
The structure of the interleukin 11 signalling complex, truncated gp130
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8dps
Q-score: 0.428
Metcalfe RD, Hanssen E, Fung KY, Aizel K, Kosasih CC, Zlatic CO, Doughty L, Morton CJ, Leis AP, Parker MW, Gooley PR, Putoczki TL, Griffin MDW
Nat Commun (2023) 14 pp. 7543-7543 [ Pubmed: 37985757 DOI: doi:10.1038/s41467-023-42754-w ]
- Interleukin-11 (18 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-11 receptor subunit alpha (Complex from Homo sapiens)
- Gp130 (Complex from Homo sapiens)
- Interleukin-11 (Complex from Homo sapiens)
- Interleukin 11 signalling complex (182 kDa, Complex)
- Interleukin-6 receptor subunit beta (34 kDa, Protein from Homo sapiens)
- Interleukin-11 receptor subunit alpha (32 kDa, Protein from Homo sapiens)
The structure of the IL-11 signalling complex, with full-length extracellular gp130
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8dpt
Q-score: 0.337
Metcalfe RD, Hanssen E, Fung KY, Aizel K, Kosasih CC, Zlatic CO, Doughty L, Morton CJ, Leis AP, Parker MW, Gooley PR, Putoczki TL, Griffin MDW
Nat Commun (2023) 14 pp. 7543-7543 [ Pubmed: 37985757 DOI: doi:10.1038/s41467-023-42754-w ]
- Interleukin-11 (18 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Il-11ra (Complex from Homo sapiens)
- Gp130 (Complex from Homo sapiens)
- Interleukin 11 signalling complex (290 kDa, Complex)
- Il-11 (Complex from Homo sapiens)
- Interleukin-11 receptor subunit alpha (32 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (67 kDa, Protein from Homo sapiens)
Cryo-EM map of human LIF signaling complex with full extracellular domains
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8d6a
Q-score: 0.357
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor (19 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human lif in complex with gp130 and lifr (Complex from Homo sapiens)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8d74
Q-score: 0.432
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Cryo-EM map of human CLCF1 signaling complex with full extracellular domains
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8d7r
Q-score: 0.268
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (36 kDa, Protein from Homo sapiens)
- Human clcf1 in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Cryo-EM map of detergent-solubilized human IL-6 signaling complex with full extracellular domains
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8d82
Q-score: 0.392
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Human il-6 in complex with il-6r alpha and detergent-solubilized gp130 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 (20 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (77 kDa, Protein from Homo sapiens)
- Soluble interleukin-6 receptor subunit alpha (38 kDa, Protein from Homo sapiens)