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Human Mitochondrial DNA Polymerase Gamma Binary Complex
Resolution: 2.37 Å
EM Method: Single-particle
Fitted PDBs: 8udl
Q-score: 0.575
Park J, Herrmann GK, Roy A, Shumate CK, Cisneros GA, Yin YW
Sci Adv (2024) 10 pp. eadl3214-eadl3214 [ Pubmed: 38787958 DOI: doi:10.1126/sciadv.adl3214 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*ap*gp*gp*tp*ap*tp*gp*gp*cp*ap*cp*tp*gp*gp*cp*cp*gp*tp*cp*gp*tp*tp*tp*t)-3') (7 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-1,dna polymerase subunit gamma-2 (Complex from Homo sapiens)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Human mitochondrial dna polymerase gamma binary complex (Complex)
- Dna (Complex)
- Dna (5'-d(p*ap*ap*ap*ap*cp*gp*ap*cp*gp*gp*cp*cp*ap*gp*tp*gp*cp*cp*ap*tp*ap*c)-3') (6 kDa, DNA from synthetic construct)
Cryo-EM structure of the Mismatch Sensing Complex (I) of Human Mitochondrial DNA Polymerase Gamma
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8g5i
Q-score: 0.47
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Cryo-em map of the mismatch sensing complex (i) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8g5j
Q-score: 0.513
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
- Cryo-em structure of the mismatch uncoupling complex (ii) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
Cryo-EM structure of the Wedge Alignment Complex (VIII) of Human Mitochondrial DNA Polymerase Gamma
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8g5k
Q-score: 0.316
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Cryo-em structure of the wedge alignment complex (viii) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
Cryo-EM structure of the Primer Separation Complex (IX) of Human Mitochondrial DNA Polymerase Gamma
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8g5l
Q-score: 0.363
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
- Cryo-em structure of the primer separation complex (ix) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
Cryo-EM structure of the Mismatch Locking Complex (III) of Human Mitochondrial DNA Polymerase Gamma
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8g5m
Q-score: 0.434
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Cryo-em structure of the mismatch locking complex (iii) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Template dna (9 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched rna primer (7 kDa, RNA from synthetic RNA)
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8g5n
Q-score: 0.384
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Mismatched rna primer (7 kDa, RNA from synthetic RNA)
- Template dna (9 kDa, DNA from synthetic construct)
- Cryo-em structure of the guide loop engagement complex (vi) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8g5o
Q-score: 0.36
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Cryo-em structure of the guide loop engagement complex (iv) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Mismatched rna primer (7 kDa, RNA from synthetic RNA)
- Template dna (9 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8g5p
Q-score: 0.411
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Mismatched rna primer (7 kDa, RNA from synthetic RNA)
- Template dna (9 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Cryo-em structure of the guide loop engagement complex (v) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8t7e
Q-score: 0.383
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
- Cryo-em map of the backtracking initiation complex (vii) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)