Structure of E6AP-E6 complex in Att1 state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8jrn
Q-score: 0.531
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Zinc ion (65 Da, Ligand)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
Structure of E6AP-E6 complex in Att2 state
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8jro
Q-score: 0.492
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Zinc ion (65 Da, Ligand)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
Structure of E6AP-E6 complex in Att3 state
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8jrp
Q-score: 0.34
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Protein e6 (17 kDa, Protein from Human papillomavirus 16)
- Zinc ion (65 Da, Ligand)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- E6ap-e6 complex (Complex from Homo sapiens)
Structure of E6AP-E6 complex in Det1 state
Resolution: 4.15 Å
EM Method: Single-particle
Fitted PDBs: 8jrq
Q-score: 0.186
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Zinc ion (65 Da, Ligand)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
Structure of E6AP-E6 complex in Det2 state
Resolution: 4.35 Å
EM Method: Single-particle
Fitted PDBs: 8jrr
Q-score: 0.164
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (16 kDa, Protein from Human papillomavirus 16)
Structure of human full-length E6AP
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- E6ap (Complex from Homo sapiens)
Cryo-EM structure of the the 2-oxoglutarate dehydrogenase (E1) with TCAIM complex
Cryo-EM structure of NLRP3 open octamer
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8swf
Q-score: 0.31
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- Nlrp3 open octamer complex (Complex from Homo sapiens)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)
Cryo-EM structure of NLRP3 closed hexamer
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 8swk
Q-score: 0.24
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea (402 Da, Ligand)
- Nlrp3 open octamer complex (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)