Li Y, Zhou M, Hu Q, Bai X-C, Huang W, Scheres SHW, Shi Y
PNAS (2017) 114 pp. 1542-1547 [ Pubmed: 28143931 DOI: doi:10.1073/pnas.1620626114 ]
- Apaf-1 apoptosome (Complex from Homo sapiens)
Li Y, Zhou M, Hu Q, Bai X-C, Huang W, Scheres SHW, Shi Y
PNAS (2017) 114 pp. 1542-1547 [ Pubmed: 28143931 DOI: doi:10.1073/pnas.1620626114 ]
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5wve
Q-score: 0.038
Li Y, Zhou M, Hu Q, Bai X-C, Huang W, Scheres SHW, Shi Y
PNAS (2017) 114 pp. 1542-1547 [ Pubmed: 28143931 DOI: doi:10.1073/pnas.1620626114 ]
- Apoptotic protease-activating factor 1 (11 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Apaf-1 card (Complex)
- Caspase-9 card (Complex)
- Apaf-1 (Complex)
- Apaf-1 apoptosome (Complex from Homo sapiens)
- Apoptotic protease-activating factor 1 (142 kDa, Protein from Homo sapiens)
- Cytochrome c (11 kDa, Protein from Equus caballus)
- Caspase (11 kDa, Protein from Homo sapiens)
- Cytochrome c (Complex)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of gamma secretase in complex with a drug DAPT
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 5fn2
Q-score: 0.323
Bai XC, Rajendra E, Yang GH, Shi YG, Scheres SHW
eLife (2015) 4 [ Pubmed: 26623517 DOI: doi:10.7554/eLife.11182 ]
- Gamma-secretase (170 kDa, Protein from Homo sapiens)
- Human gamma secretase in complex with a drug dapt (170 kDa, Sample)
Cryo-EM structure of gamma secretase in class 1 of the apo-state ensemble
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 5fn3
Q-score: 0.291
Bai XC, Rajendra E, Yang GH, Shi YG, Scheres SHW
eLife (2015) 4 [ Pubmed: 26623517 DOI: doi:10.7554/eLife.11182 ]
- Gamma-secretase (170 kDa, Protein from Homo sapiens)
- Human gamma secretase in class 1 of the apo-state ensemble (170 kDa, Sample)
Cryo-EM structure of gamma secretase in class 2 of the apo-state ensemble
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5fn4
Q-score: 0.333
Bai XC, Rajendra E, Yang GH, Shi YG, Scheres SHW
eLife (2015) 4 [ Pubmed: 26623517 DOI: doi:10.7554/eLife.11182 ]
- Human gamma secretase in class 2 of the apo-state ensemble (170 kDa, Sample)
- Gamma-secretase (170 kDa, Protein from Homo sapiens)
Cryo-EM structure of gamma secretase in class 3 of the apo-state ensemble
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5fn5
Q-score: 0.292
Bai XC, Rajendra E, Yang GH, Shi YG, Scheres SHW
eLife (2015) 4 [ Pubmed: 26623517 DOI: doi:10.7554/eLife.11182 ]
- Gamma-secretase (170 kDa, Protein from Homo sapiens)
- Human gamma secretase in class 3 of the apo-state ensemble (170 kDa, Sample)
Atomic structure of the Apaf-1 apoptosome
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 3jbt
Q-score: 0.201
Zhou MY, Li YN, Hu Q, Bai XC, Huang WY, Yan CY, Scheres SHW, Shi YG
Genes Dev (2015) [ Pubmed: 26543158 DOI: doi:10.1101/gad.272278.115 ]
Atomic structure of the Apaf-1 apoptosome
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 3jbt
Q-score: 0.128
Zhou MY, Li YN, Hu Q, Bai XC, Huang WY, Yan CY, Scheres SHW, Shi YG
Genes Dev (2015) [ Pubmed: 26543158 DOI: doi:10.1101/gad.272278.115 ]
Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 5a63
Q-score: 0.457
Bai XC, Yan CY, Yang GH, Lu PL, Ma D, Sun LF, Zhou R, Scheres SHW, Shi YG
Nature (2015) 525 pp. 212-217 [ Pubmed: 26280335 DOI: doi:10.1038/NATURE14892 ]
- Human gamma-secretase (170 kDa, Sample)
- Gamma-secretase (170 kDa, Protein from Homo sapiens)