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Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ore
Q-score: 0.593
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ Pubmed: 37337995 DOI: doi:10.1002/2211-5463.13657 ]
- Tau amyloid filaments (Cell from Homo sapiens)
- Microtubule-associated protein tau (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8orf
Q-score: 0.601
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ Pubmed: 37337995 DOI: doi:10.1002/2211-5463.13657 ]
- Tau amyloid filaments (Cell from Homo sapiens)
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II)
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8org
Q-score: 0.606
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ Pubmed: 37337995 DOI: doi:10.1002/2211-5463.13657 ]
- Tau amyloid filaments (Cell from Homo sapiens)
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
Resolution: 3.47 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nca
Q-score: 0.559
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ Pubmed: 33548114 DOI: doi:10.1002/2211-5463.13110 ]
- Alpha synuclein filament (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Resolution: 3.43 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ncg
Q-score: 0.494
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ Pubmed: 33548114 DOI: doi:10.1002/2211-5463.13110 ]
- Alpha synuclein filament (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Resolution: 3.84 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nch
Q-score: 0.244
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ Pubmed: 33548114 DOI: doi:10.1002/2211-5463.13110 ]
- Alpha synuclein filament (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Resolution: 3.55 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nci
Q-score: 0.377
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ Pubmed: 33548114 DOI: doi:10.1002/2211-5463.13110 ]
- Alpha synuclein filament (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Resolution: 4.23 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ncj
Q-score: 0.176
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ Pubmed: 33548114 DOI: doi:10.1002/2211-5463.13110 ]
- Alpha synuclein filament (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Resolution: 3.18 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nck
Q-score: 0.498
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ Pubmed: 33548114 DOI: doi:10.1002/2211-5463.13110 ]
- Alpha synuclein filament (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
Nature (2020) 585 pp. 464-469 [ Pubmed: 32461689 DOI: 10.1038/s41586-020-2317-6 ]
Image sets: