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Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8dty
Q-score: 0.309
Hu Y, Iyer KA, Nayak AR, Eltit JM, Kurebayashi N, Murayama T, Samso M
To Be Published
- Ryanodine receptor 2 (565 kDa, Protein from Mus musculus)
- Recombinant mouse ryr2 triple phosphomimetic mutant s2807d/s2813d/s2030d in complex with fkbp12.6 and nanodisc under closed-state conditions (2 MDa, Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8dtz
Q-score: 0.302
Hu Y, Iyer KA, Nayak AR, Eltit JM, Kurebayashi N, Murayama T, Samso M
To Be Published
- Recombinant mouse ryr2 triple phosphonull mutant s2807a/s2813a/s2030a in complex with fkbp12.6 and nanodisc under closed-state conditions (2 MDa, Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Mus musculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8dvv
Q-score: 0.318
Hu Y, Iyer KA, Nayak AR, Eltit JM, Kurebayashi N, Murayama T, Samso M
To Be Published
- Ryanodine receptor 2 (565 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Recombinant mouse ryr2 triple phosphomimetic mutant s2807d/s2813d/s2030d in complex with fkbp12.6 and nanodisc under open-state conditions (2 MDa, Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of the Mismatch Sensing Complex (I) of Human Mitochondrial DNA Polymerase Gamma
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8g5i
Q-score: 0.47
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Cryo-em map of the mismatch sensing complex (i) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8g5j
Q-score: 0.513
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
- Cryo-em structure of the mismatch uncoupling complex (ii) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
Cryo-EM structure of the Wedge Alignment Complex (VIII) of Human Mitochondrial DNA Polymerase Gamma
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8g5k
Q-score: 0.316
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Cryo-em structure of the wedge alignment complex (viii) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
Cryo-EM structure of the Primer Separation Complex (IX) of Human Mitochondrial DNA Polymerase Gamma
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8g5l
Q-score: 0.363
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched primer dna (6 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Template dna (7 kDa, DNA from synthetic construct)
- Cryo-em structure of the primer separation complex (ix) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
Cryo-EM structure of the Mismatch Locking Complex (III) of Human Mitochondrial DNA Polymerase Gamma
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8g5m
Q-score: 0.434
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Cryo-em structure of the mismatch locking complex (iii) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Template dna (9 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
- Mismatched rna primer (7 kDa, RNA from synthetic RNA)
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8g5n
Q-score: 0.384
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Mismatched rna primer (7 kDa, RNA from synthetic RNA)
- Template dna (9 kDa, DNA from synthetic construct)
- Cryo-em structure of the guide loop engagement complex (vi) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8g5o
Q-score: 0.36
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D
Nat Commun (2023) 14 pp. 8501-8501 [ DOI: doi:10.1038/s41467-023-44198-8 Pubmed: 38151585 ]
- Cryo-em structure of the guide loop engagement complex (iv) of human mitochondrial dna polymerase gamma (362 kDa, Complex from Homo sapiens)
- Dna polymerase subunit gamma-2, mitochondrial (54 kDa, Protein from Homo sapiens)
- Mismatched rna primer (7 kDa, RNA from synthetic RNA)
- Template dna (9 kDa, DNA from synthetic construct)
- Dna polymerase subunit gamma-1 (139 kDa, Protein from Homo sapiens)