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initial_angle_assignment_type:"MAXIMUM LIKELIHOOD" AND xref_links:"pdb" AND citation_journal_name:"TO BE PUBLISHED" AND author_orcid:"0000-0002-4285-435x"
Structure of the HER4/NRG1b Homodimer Extracellular Domain
Release date: March 13, 2024
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8u4i
Q-score: 0.388
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8u4i
Q-score: 0.388
Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
To Be Published
Sample:
- Receptor tyrosine-protein kinase erbb-4 (68 kDa, Protein from Homo sapiens)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (5 kDa, Protein from Homo sapiens)
- Her4/nrg1b homodimer (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the HER4/BTC Homodimer Extracellular Domain
Release date: March 13, 2024
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8u4j
Q-score: 0.359
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8u4j
Q-score: 0.359
Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
To Be Published
Sample:
- Receptor tyrosine-protein kinase erbb-4 (68 kDa, Protein from Homo sapiens)
- Betacellulin (5 kDa, Protein from Homo sapiens)
- Her4/btc homodimer (306 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain
Release date: March 13, 2024
Resolution: 4.27 Å
EM Method: Single-particle
Fitted PDBs: 8u4k
Q-score: 0.284
Resolution: 4.27 Å
EM Method: Single-particle
Fitted PDBs: 8u4k
Q-score: 0.284
Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
To Be Published
Sample:
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Receptor tyrosine-protein kinase erbb-2 (66 kDa, Protein from Homo sapiens)
- Ternary complex of her2/her4/btc (284 kDa, Complex from Homo sapiens)
- Isoform jm-a cyt-1 of receptor tyrosine-protein kinase erbb-4 (67 kDa, Protein from Homo sapiens)
- Betacellulin (5 kDa, Protein from Homo sapiens)
Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
Release date: March 13, 2024
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8u4l
Q-score: 0.423
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8u4l
Q-score: 0.423
Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
To Be Published
Sample:
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Receptor tyrosine-protein kinase erbb-2 (66 kDa, Protein from Homo sapiens)
- Ternary complex of her2/her4/nrg1b (Complex from Homo sapiens)
- Isoform jm-a cyt-1 of receptor tyrosine-protein kinase erbb-4 (67 kDa, Protein from Homo sapiens)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (5 kDa, Protein from Homo sapiens)