Electron Microscopy Data Bank

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initial_angle_assignment_type:"MAXIMUM LIKELIHOOD" AND xref_links:"pdb" AND assembly_molecular_weight:{2000000 TO 5000000] AND natural_source_ncbi_code:"2697049"

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EMD-12756

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Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution)

Release date: June 2, 2021
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7o7y
Q-score: 0.624

Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, Dreos R, O'Connor KM, McMillan A, Bode JW, Thiel V, Gatfield D, Atkins JF, Ban N

Science (2021) 372 pp. 1306-1313 [ Pubmed: 34029205 DOI: doi:10.1126/science.abf3546 ]

Sample:

Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
E-site trna (15 kDa, RNA from Bos taurus)
Replicase polyprotein 1ab (Complex from Severe acute respiratory syndrome coronavirus 2)
40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
Spermine (202 Da, Ligand)
60s ribosomal protein l36 (12 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es4 (29 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
Mrna containing sars-cov-2 sequence (69 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul30 (29 kDa, Protein from Oryctolagus cuniculus)
El39 (6 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es26 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein us5 (31 kDa, Protein from Oryctolagus cuniculus)
Ul22 (21 kDa, Protein from Oryctolagus cuniculus)
28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
El31 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
El42 (12 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein sa (32 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es19 (16 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s27a (18 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l4 (46 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l12 (17 kDa, Protein from Oryctolagus cuniculus)
Water (18 Da, Ligand)
El43 (10 kDa, Protein from Oryctolagus cuniculus)
5.8s rrna (50 kDa, RNA from Oryctolagus cuniculus)
Ribosomal protein ul13 (23 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el18 (21 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome stalled (Complex from Bos taurus)
Spermidine (145 Da, Ligand)
Ribosomal protein s5 (22 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el22 (14 kDa, Protein from Oryctolagus cuniculus)
Ul23 (17 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s7 (47 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el28 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
Unknown atom or ion (Ligand)
60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
P-site phe-trna(phe) (24 kDa, RNA from Bos taurus)
Us14 (6 kDa, Protein from Oryctolagus cuniculus)
El21 (18 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
60s acidic ribosomal protein p0 (34 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el20 (20 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l34 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul2 (28 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
El24 (17 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s18 (17 kDa, Protein from Oryctolagus cuniculus)
Magnesium ion (24 Da, Ligand)
Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s3 (31 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l29 (26 kDa, Protein from Oryctolagus cuniculus)
El32 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
Replicase polyprotein 1ab (121 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Rack1 (35 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome stalled (Complex from Oryctolagus cuniculus)
Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s6 (28 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
El33 (12 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s8 (24 kDa, Protein from Oryctolagus cuniculus)
Us15 (17 kDa, Protein from Oryctolagus cuniculus)
El38 (8 kDa, Protein from Oryctolagus cuniculus)
Sars-cov-2 slippery site by a pseudoknot (Complex from Severe acute respiratory syndrome coronavirus 2)
18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
Ribosomal_l18_c domain-containing protein (34 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s9 (predicted) (22 kDa, Protein from Oryctolagus cuniculus)
5s rrna (38 kDa, RNA from Oryctolagus cuniculus)
60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
Es10 (18 kDa, Protein from Oryctolagus cuniculus)
Zinc ion (65 Da, Ligand)
El30 (12 kDa, Protein from Oryctolagus cuniculus)
Us9 (19 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l40 (14 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el8 (30 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s3a (30 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome stalled close to the mutated sars-cov-2 slippery site by a pseudoknot (Complex)
Ribosomal protein el13 (24 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es21 (9 kDa, Protein from Oryctolagus cuniculus)
Ul29 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul1 (24 kDa, Protein from Oryctolagus cuniculus)

[Show more]

EMD-12757

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Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot)

Release date: June 2, 2021
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7o7z
Q-score: 0.576

Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, Dreos R, O'Connor KM, McMillan A, Bode JW, Thiel V, Gatfield D, Atkins JF, Ban N

Science (2021) 372 pp. 1306-1313 [ Pubmed: 34029205 DOI: doi:10.1126/science.abf3546 ]

Sample:

Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
E-site trna (15 kDa, RNA from Bos taurus)
Replicase polyprotein 1ab (Complex from Severe acute respiratory syndrome coronavirus 2)
40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
Mrna containing sars-cov-2 sequence (70 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
60s ribosomal protein l36 (12 kDa, Protein from Oryctolagus cuniculus)
Spermine (202 Da, Ligand)
Ribosomal protein es4 (29 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul30 (29 kDa, Protein from Oryctolagus cuniculus)
El39 (6 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es26 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein us5 (31 kDa, Protein from Oryctolagus cuniculus)
Ul22 (21 kDa, Protein from Oryctolagus cuniculus)
28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
El31 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
El42 (12 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein sa (32 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es19 (16 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s27a (18 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l4 (46 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l12 (17 kDa, Protein from Oryctolagus cuniculus)
Water (18 Da, Ligand)
El43 (10 kDa, Protein from Oryctolagus cuniculus)
5.8s rrna (50 kDa, RNA from Oryctolagus cuniculus)
Ribosomal protein ul13 (23 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el18 (21 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome stalled (Complex from Bos taurus)
Spermidine (145 Da, Ligand)
Ribosomal protein s5 (22 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el22 (14 kDa, Protein from Oryctolagus cuniculus)
Ul23 (17 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s7 (47 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el28 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
Unknown atom or ion (Ligand)
60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
Us14 (6 kDa, Protein from Oryctolagus cuniculus)
El21 (18 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
60s acidic ribosomal protein p0 (34 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el20 (20 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l34 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul2 (28 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
El24 (17 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s18 (17 kDa, Protein from Oryctolagus cuniculus)
Magnesium ion (24 Da, Ligand)
Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s3 (31 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l29 (26 kDa, Protein from Oryctolagus cuniculus)
18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
El32 (15 kDa, Protein from Oryctolagus cuniculus)
P-site phe-trna(phe) (24 kDa, RNA from Bos taurus)
40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
Replicase polyprotein 1ab (121 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Rack1 (35 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome stalled (Complex from Oryctolagus cuniculus)
Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s6 (28 kDa, Protein from Oryctolagus cuniculus)
5s (38 kDa, RNA from Oryctolagus cuniculus)
40s ribosomal protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
El33 (12 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s8 (24 kDa, Protein from Oryctolagus cuniculus)
Us15 (17 kDa, Protein from Oryctolagus cuniculus)
El38 (8 kDa, Protein from Oryctolagus cuniculus)
Sars-cov-2 slippery site by a pseudoknot (Complex from Severe acute respiratory syndrome coronavirus 2)
Ribosomal_l18_c domain-containing protein (34 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s9 (predicted) (22 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
Es10 (18 kDa, Protein from Oryctolagus cuniculus)
Zinc ion (65 Da, Ligand)
El30 (12 kDa, Protein from Oryctolagus cuniculus)
Us9 (19 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l40 (14 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el8 (30 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s3a (30 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome stalled close to the mutated sars-cov-2 slippery site by a pseudoknot (Complex)
Ribosomal protein el13 (24 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es21 (9 kDa, Protein from Oryctolagus cuniculus)
Ul29 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul1 (24 kDa, Protein from Oryctolagus cuniculus)

[Show more]

EMD-12758

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Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site

Release date: June 2, 2021
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7o80
Q-score: 0.497

Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, Dreos R, O'Connor KM, McMillan A, Bode JW, Thiel V, Gatfield D, Atkins JF, Ban N

Science (2021) 372 pp. 1306-1313 [ Pubmed: 34029205 DOI: doi:10.1126/science.abf3546 ]

Sample:

Rabbit 80s ribosome in complex with erf1 and abce1 stalled at the stop codon in the mutated sars-cov-2 slippery site (Complex)
Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
E-site trna (15 kDa, RNA from Bos taurus)
Replicase polyprotein 1ab (Complex from Severe acute respiratory syndrome coronavirus 2)
Rabbit 80s ribosome (Complex from Oryctolagus cuniculus)
40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l36 (12 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es4 (29 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
Mrna containing sars-cov-2 sequence (69 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul30 (29 kDa, Protein from Oryctolagus cuniculus)
El39 (6 kDa, Protein from Oryctolagus cuniculus)
Sars-cov-2 slippery site (Complex from Severe acute respiratory syndrome coronavirus 2)
Ribosomal protein es26 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein us5 (31 kDa, Protein from Oryctolagus cuniculus)
Ul22 (21 kDa, Protein from Oryctolagus cuniculus)
28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
Atp binding cassette subfamily e member 1 (67 kDa, Protein from Oryctolagus cuniculus)
El31 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
El42 (12 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein sa (32 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es19 (16 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s27a (18 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l4 (46 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l12 (17 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l13a (23 kDa, Protein from Oryctolagus cuniculus)
Water (18 Da, Ligand)
El43 (10 kDa, Protein from Oryctolagus cuniculus)
5.8s rrna (50 kDa, RNA from Oryctolagus cuniculus)
Ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
Spermidine (145 Da, Ligand)
Ribosomal protein s5 (22 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s16 (16 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el22 (14 kDa, Protein from Oryctolagus cuniculus)
Ul23 (17 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el28 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
Unknown atom or ion (Ligand)
5s rrna (38 kDa, RNA from Oryctolagus cuniculus)
60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
Us14 (6 kDa, Protein from Oryctolagus cuniculus)
El21 (18 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
Eukaryotic peptide chain release factor subunit 1 (49 kDa, Protein from Oryctolagus cuniculus)
60s acidic ribosomal protein p0 (34 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein (24 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l34 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul2 (28 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
P-site leu-trna(leu) (27 kDa, RNA from Bos taurus)
40s ribosomal protein s18 (17 kDa, Protein from Oryctolagus cuniculus)
El24 (17 kDa, Protein from Oryctolagus cuniculus)
Magnesium ion (24 Da, Ligand)
Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s3 (31 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
Eukaryotic peptide chain release factor subunit 1 (Complex from Oryctolagus cuniculus)
60s ribosomal protein l29 (26 kDa, Protein from Oryctolagus cuniculus)
18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
El32 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
Replicase polyprotein 1ab (121 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Ribosomal protein l18a (20 kDa, Protein from Oryctolagus cuniculus)
Rack1 (35 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome (Complex from Bos taurus)
40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l18 (21 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
Iron/sulfur cluster (351 Da, Ligand)
40s ribosomal protein s6 (28 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
El33 (12 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s7 (22 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s8 (24 kDa, Protein from Oryctolagus cuniculus)
Us15 (17 kDa, Protein from Oryctolagus cuniculus)
El38 (8 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es10 (18 kDa, Protein from Oryctolagus cuniculus)
Guanosine-5'-triphosphate (523 Da, Ligand)
Ribosomal_l18_c domain-containing protein (34 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s9 (predicted) (22 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
Zinc ion (65 Da, Ligand)
El30 (12 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l40 (14 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el8 (30 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s3a (30 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el13 (24 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es21 (9 kDa, Protein from Oryctolagus cuniculus)
Ul29 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)

[Show more]

EMD-12759

Download Map 3D View

Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot

Release date: June 2, 2021
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7o81
Q-score: 0.447

Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, Dreos R, O'Connor KM, McMillan A, Bode JW, Thiel V, Gatfield D, Atkins JF, Ban N

Science (2021) 372 pp. 1306-1313 [ Pubmed: 34029205 DOI: doi:10.1126/science.abf3546 ]

Sample:

Ribosomal protein l15 (24 kDa, Protein from Oryctolagus cuniculus)
Replicase polyprotein 1ab (Complex from Severe acute respiratory syndrome coronavirus 2)
40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l36 (12 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es4 (29 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l37 (11 kDa, Protein from Oryctolagus cuniculus)
Mrna containing sars-cov-2 sequence (69 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
60s ribosomal protein l6 (33 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul30 (29 kDa, Protein from Oryctolagus cuniculus)
El39 (6 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es26 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein us5 (31 kDa, Protein from Oryctolagus cuniculus)
Ul22 (21 kDa, Protein from Oryctolagus cuniculus)
28s rrna (1 MDa, RNA from Oryctolagus cuniculus)
El31 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s11 (18 kDa, Protein from Oryctolagus cuniculus)
El42 (12 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein sa (32 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es19 (16 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome colliding in another ribosome (Complex from Bos taurus)
Ribosomal protein s27a (18 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l4 (46 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l12 (17 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l13a (23 kDa, Protein from Oryctolagus cuniculus)
Water (18 Da, Ligand)
El43 (10 kDa, Protein from Oryctolagus cuniculus)
5.8s rrna (50 kDa, RNA from Oryctolagus cuniculus)
Ribosomal protein s28 (7 kDa, Protein from Oryctolagus cuniculus)
Spermidine (145 Da, Ligand)
Ribosomal protein s5 (22 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el22 (14 kDa, Protein from Oryctolagus cuniculus)
Ul23 (17 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s7 (47 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l27 (15 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el28 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
Unknown atom or ion (Ligand)
60s ribosomal protein l10 (24 kDa, Protein from Oryctolagus cuniculus)
Us14 (6 kDa, Protein from Oryctolagus cuniculus)
El21 (18 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
A-site met-trna(met) (24 kDa, RNA from Bos taurus)
60s acidic ribosomal protein p0 (34 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l34 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul2 (28 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
El24 (17 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s18 (17 kDa, Protein from Oryctolagus cuniculus)
Magnesium ion (24 Da, Ligand)
Ribosomal protein s15a (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s3 (31 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l11 (20 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l19 (23 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l29 (26 kDa, Protein from Oryctolagus cuniculus)
18s rrna (603 kDa, RNA from Oryctolagus cuniculus)
El32 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s23 (15 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
60s ribosomal protein l9 (21 kDa, Protein from Oryctolagus cuniculus)
Replicase polyprotein 1ab (121 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Ribosomal protein l18a (20 kDa, Protein from Oryctolagus cuniculus)
Rack1 (35 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s30 (14 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l3 (46 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l18 (21 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s25 (13 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l23 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s6 (28 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
Sars-cov-2 pseudoknot (Complex from Severe acute respiratory syndrome coronavirus 2)
El33 (12 kDa, Protein from Oryctolagus cuniculus)
P-site trna(pro) (24 kDa, RNA from Bos taurus)
40s ribosomal protein s8 (24 kDa, Protein from Oryctolagus cuniculus)
Us15 (17 kDa, Protein from Oryctolagus cuniculus)
El38 (8 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es10 (18 kDa, Protein from Oryctolagus cuniculus)
Ribosomal_l18_c domain-containing protein (34 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein s9 (predicted) (22 kDa, Protein from Oryctolagus cuniculus)
5s rrna (38 kDa, RNA from Oryctolagus cuniculus)
60s ribosomal protein l27a (16 kDa, Protein from Oryctolagus cuniculus)
Zinc ion (65 Da, Ligand)
El30 (12 kDa, Protein from Oryctolagus cuniculus)
Us9 (19 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome colliding in another ribosome (Complex from Oryctolagus cuniculus)
60s ribosomal protein l40 (14 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l26 (17 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein l14 (23 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el8 (30 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s3a (30 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein el13 (24 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein es21 (9 kDa, Protein from Oryctolagus cuniculus)
Rabbit 80s ribosome colliding in another ribosome stalled by the sars-cov-2 pseudoknot (Complex)
Edf1 (16 kDa, Protein from Oryctolagus cuniculus)
Ul29 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s12 (14 kDa, Protein from Oryctolagus cuniculus)
40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
Ribosomal protein ul1 (24 kDa, Protein from Oryctolagus cuniculus)

[Show more]

EMD-11292

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SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex

Release date: Aug. 19, 2020
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6zmi
Q-score: 0.575

Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, Mackens-Kiani T, Cheng J, Straub JH, Sturzel CM, Frohlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer KMJ, Beckmann R

Science (2020) 369 pp. 1249-1255 [ DOI: doi:10.1126/science.abc8665 Pubmed: 32680882 ]

Sample:

60s ribosomal protein l32 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
28s ribosomal rna (1 MDa, RNA from Homo sapiens)
60s ribosomal protein l14 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l12 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
5s ribosomal rna (38 kDa, RNA from Homo sapiens)
60s ribosomal protein l17 (21 kDa, Protein from Homo sapiens)
Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
60s ribosomal protein l30 (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
60s ribosomal protein l36 (12 kDa, Protein from Homo sapiens)
60s ribosomal protein l4 (47 kDa, Protein from Homo sapiens)
40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
60s ribosomal protein l13 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l23a (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l28 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
60s ribosomal protein l19 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l37a (10 kDa, Protein from Homo sapiens)
60s ribosomal protein l18 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l29 (17 kDa, Protein from Homo sapiens)
60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
5.8s ribosomal rna (50 kDa, RNA from Homo sapiens)
60s ribosomal protein l22 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l6 (32 kDa, Protein from Homo sapiens)
40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l10a (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l39 (6 kDa, Protein from Homo sapiens)
60s ribosomal protein l35 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l38 (8 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l23 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
Proliferation-associated protein 2g4 (43 kDa, Protein from Homo sapiens)
18s ribosomal rna (602 kDa, RNA from Homo sapiens)
60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
60s ribosomal protein l8 (28 kDa, Protein from Homo sapiens)
40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
Non-structural protein 1 (19 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
60s ribosomal protein l24 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 (Complex from Severe acute respiratory syndrome coronavirus 2)
Human lyar-80s ribosome complex (Complex from Homo sapiens)
Trna (24 kDa, RNA from Homo sapiens)
40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l15 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l7a (30 kDa, Protein from Homo sapiens)
40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
60s ribosomal protein l7 (29 kDa, Protein from Homo sapiens)
60s ribosomal protein l31 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l3 (46 kDa, Protein from Homo sapiens)
60s ribosomal protein l37 (11 kDa, Protein from Homo sapiens)
40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 bound to the human lyar-80s ribosome complex (Complex)
Zinc ion (65 Da, Ligand)
60s ribosomal protein l35a (12 kDa, Protein from Homo sapiens)
60s acidic ribosomal protein p0 (34 kDa, Protein from Homo sapiens)
Cell growth-regulating nucleolar protein (43 kDa, Protein from Homo sapiens)
60s ribosomal protein l10-like (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l36a (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
60s ribosomal protein l34 (13 kDa, Protein from Homo sapiens)
60s ribosomal protein l21 (18 kDa, Protein from Homo sapiens)
60s ribosomal protein l9 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l26 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
60s ribosomal protein l13a (23 kDa, Protein from Homo sapiens)
40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
60s ribosomal protein l27a (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l18a (20 kDa, Protein from Homo sapiens)
60s ribosomal protein l27 (15 kDa, Protein from Homo sapiens)

[Show more]

EMD-11299

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SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex

Release date: Aug. 19, 2020
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6zmo
Q-score: 0.519

Science (2020) 369 pp. 1249-1255 [ DOI: doi:10.1126/science.abc8665 Pubmed: 32680882 ]

Sample:

60s ribosomal protein l32 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
28s ribosomal rna (1 MDa, RNA from Homo sapiens)
60s ribosomal protein l14 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l12 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
5s ribosomal rna (38 kDa, RNA from Homo sapiens)
60s ribosomal protein l17 (21 kDa, Protein from Homo sapiens)
Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
60s ribosomal protein l30 (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
60s ribosomal protein l36 (12 kDa, Protein from Homo sapiens)
60s ribosomal protein l4 (47 kDa, Protein from Homo sapiens)
40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
60s ribosomal protein l13 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l23a (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l28 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
60s ribosomal protein l19 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l37a (10 kDa, Protein from Homo sapiens)
60s ribosomal protein l18 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l29 (17 kDa, Protein from Homo sapiens)
60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
5.8s ribosomal rna (50 kDa, RNA from Homo sapiens)
60s ribosomal protein l22 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l6 (32 kDa, Protein from Homo sapiens)
40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
Trna (28 kDa, RNA from Homo sapiens)
40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l10a (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l39 (6 kDa, Protein from Homo sapiens)
60s ribosomal protein l35 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l38 (8 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l23 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
Proliferation-associated protein 2g4 (43 kDa, Protein from Homo sapiens)
18s ribosomal rna (602 kDa, RNA from Homo sapiens)
60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
60s ribosomal protein l8 (28 kDa, Protein from Homo sapiens)
40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
Non-structural protein 1 (19 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
60s ribosomal protein l24 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 (Complex from Severe acute respiratory syndrome coronavirus 2)
Trna (24 kDa, RNA from Homo sapiens)
Elongation factor 1-alpha 1 (50 kDa, Protein from Homo sapiens)
40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l15 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l7a (30 kDa, Protein from Homo sapiens)
40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
60s ribosomal protein l7 (29 kDa, Protein from Homo sapiens)
60s ribosomal protein l31 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l3 (46 kDa, Protein from Homo sapiens)
60s ribosomal protein l37 (11 kDa, Protein from Homo sapiens)
40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
60s ribosomal protein l35a (12 kDa, Protein from Homo sapiens)
60s acidic ribosomal protein p0 (34 kDa, Protein from Homo sapiens)
Cell growth-regulating nucleolar protein (43 kDa, Protein from Homo sapiens)
60s ribosomal protein l10-like (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l36a (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
60s ribosomal protein l34 (13 kDa, Protein from Homo sapiens)
60s ribosomal protein l21 (18 kDa, Protein from Homo sapiens)
60s ribosomal protein l9 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l26 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 bound to the human lyar-80s-eef1a ribosome complex (Complex)
60s ribosomal protein l13a (23 kDa, Protein from Homo sapiens)
40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
Human lyar-80s-eef1a ribosome complex (Complex from Homo sapiens)
40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
60s ribosomal protein l27a (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l18a (20 kDa, Protein from Homo sapiens)
60s ribosomal protein l27 (15 kDa, Protein from Homo sapiens)

[Show more]

EMD-11289

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SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex

Release date: Aug. 12, 2020
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6zme
Q-score: 0.52

Science (2020) 369 pp. 1249-1255 [ DOI: doi:10.1126/science.abc8665 Pubmed: 32680882 ]

Sample:

60s ribosomal protein l32 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
28s ribosomal rna (1 MDa, RNA from Homo sapiens)
60s ribosomal protein l14 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l12 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
5s ribosomal rna (38 kDa, RNA from Homo sapiens)
60s ribosomal protein l17 (21 kDa, Protein from Homo sapiens)
Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
60s ribosomal protein l30 (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
60s ribosomal protein l36 (12 kDa, Protein from Homo sapiens)
60s ribosomal protein l4 (47 kDa, Protein from Homo sapiens)
40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
60s ribosomal protein l13 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l23a (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l28 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
60s ribosomal protein l19 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l37a (10 kDa, Protein from Homo sapiens)
60s ribosomal protein l18 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l29 (17 kDa, Protein from Homo sapiens)
60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
5.8s ribosomal rna (50 kDa, RNA from Homo sapiens)
60s ribosomal protein l22 (14 kDa, Protein from Homo sapiens)
Human ccdc124-80s-eerf1 ribosome complex (Complex from Homo sapiens)
40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l6 (32 kDa, Protein from Homo sapiens)
40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
Atp-binding cassette sub-family e member 1 (67 kDa, Protein from Homo sapiens)
40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l10a (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l39 (6 kDa, Protein from Homo sapiens)
60s ribosomal protein l35 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l38 (8 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
Coiled-coil domain-containing protein 124 (25 kDa, Protein from Homo sapiens)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l23 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
Proliferation-associated protein 2g4 (43 kDa, Protein from Homo sapiens)
18s ribosomal rna (602 kDa, RNA from Homo sapiens)
60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
60s ribosomal protein l8 (28 kDa, Protein from Homo sapiens)
40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
Non-structural protein 1 (19 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
60s ribosomal protein l24 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 (Complex from Severe acute respiratory syndrome coronavirus 2)
Iron/sulfur cluster (351 Da, Ligand)
Eukaryotic peptide chain release factor subunit 1 (49 kDa, Protein from Homo sapiens)
Trna (24 kDa, RNA from Homo sapiens)
40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l15 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l7a (30 kDa, Protein from Homo sapiens)
40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
60s ribosomal protein l7 (29 kDa, Protein from Homo sapiens)
60s ribosomal protein l31 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l3 (46 kDa, Protein from Homo sapiens)
60s ribosomal protein l37 (11 kDa, Protein from Homo sapiens)
40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
60s ribosomal protein l35a (12 kDa, Protein from Homo sapiens)
60s acidic ribosomal protein p0 (34 kDa, Protein from Homo sapiens)
60s ribosomal protein l10-like (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l36a (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
60s ribosomal protein l34 (13 kDa, Protein from Homo sapiens)
60s ribosomal protein l21 (18 kDa, Protein from Homo sapiens)
60s ribosomal protein l9 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l26 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
60s ribosomal protein l13a (23 kDa, Protein from Homo sapiens)
40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 bound to the human ccdc124-80s-eerf1 ribosome complex (Complex)
60s ribosomal protein l27a (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l18a (20 kDa, Protein from Homo sapiens)
60s ribosomal protein l27 (15 kDa, Protein from Homo sapiens)

[Show more]

EMD-11288

Download Map 3D View

SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex

Release date: July 29, 2020
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6zm7
Q-score: 0.563

Science (2020) 369 pp. 1249-1255 [ DOI: doi:10.1126/science.abc8665 Pubmed: 32680882 ]

Sample:

60s ribosomal protein l32 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
28s ribosomal rna (1 MDa, RNA from Homo sapiens)
60s ribosomal protein l14 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l12 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
5s ribosomal rna (38 kDa, RNA from Homo sapiens)
60s ribosomal protein l17 (21 kDa, Protein from Homo sapiens)
Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
60s ribosomal protein l30 (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
60s ribosomal protein l36 (12 kDa, Protein from Homo sapiens)
60s ribosomal protein l4 (47 kDa, Protein from Homo sapiens)
40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
60s ribosomal protein l13 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l23a (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l28 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
60s ribosomal protein l19 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l37a (10 kDa, Protein from Homo sapiens)
60s ribosomal protein l18 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l29 (17 kDa, Protein from Homo sapiens)
60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
5.8s ribosomal rna (50 kDa, RNA from Homo sapiens)
60s ribosomal protein l22 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l6 (32 kDa, Protein from Homo sapiens)
40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l10a (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l39 (6 kDa, Protein from Homo sapiens)
60s ribosomal protein l35 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l38 (8 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
Coiled-coil domain-containing protein 124 (25 kDa, Protein from Homo sapiens)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l23 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
Proliferation-associated protein 2g4 (43 kDa, Protein from Homo sapiens)
18s ribosomal rna (602 kDa, RNA from Homo sapiens)
60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
60s ribosomal protein l8 (28 kDa, Protein from Homo sapiens)
40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
Non-structural protein 1 (19 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
60s ribosomal protein l24 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 (Complex from Severe acute respiratory syndrome coronavirus 2)
Trna (24 kDa, RNA from Homo sapiens)
40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l15 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l7a (30 kDa, Protein from Homo sapiens)
40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
60s ribosomal protein l7 (29 kDa, Protein from Homo sapiens)
60s ribosomal protein l31 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l3 (46 kDa, Protein from Homo sapiens)
60s ribosomal protein l37 (11 kDa, Protein from Homo sapiens)
40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
60s ribosomal protein l35a (12 kDa, Protein from Homo sapiens)
60s acidic ribosomal protein p0 (34 kDa, Protein from Homo sapiens)
Human 80s-ccdc124-ebp1 ribosome complex (Complex from Homo sapiens)
60s ribosomal protein l10-like (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l36a (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
60s ribosomal protein l34 (13 kDa, Protein from Homo sapiens)
60s ribosomal protein l21 (18 kDa, Protein from Homo sapiens)
60s ribosomal protein l9 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l26 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 bound to the human 80s-ccdc124 ribosome complex (Complex)
40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
60s ribosomal protein l13a (23 kDa, Protein from Homo sapiens)
40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
60s ribosomal protein l27a (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l18a (20 kDa, Protein from Homo sapiens)
60s ribosomal protein l27 (15 kDa, Protein from Homo sapiens)

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EMD-11335

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SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2

Release date: July 29, 2020
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6zp4
Q-score: 0.476

Science (2020) 369 pp. 1249-1255 [ DOI: doi:10.1126/science.abc8665 Pubmed: 32680882 ]

Sample:

Guanosine-5'-triphosphate (523 Da, Ligand)
40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit c (105 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 2 subunit 3 (51 kDa, Protein from Homo sapiens)
40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit m (42 kDa, Protein from Homo sapiens)
40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit i (36 kDa, Protein from Homo sapiens)
40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
Unknown factor (5 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
18s ribosomal rna (602 kDa, RNA from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit k (25 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit l (66 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit b (92 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit a (166 kDa, Protein from Homo sapiens)
Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
Non-structural protein 1 (19 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Human 43s preinitiation ribosome complex - state 2 (Complex from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit h (39 kDa, Protein from Homo sapiens)
40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 (Complex from Severe acute respiratory syndrome coronavirus 2)
40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 1a, x-chromosomal (16 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 2 subunit 2 (38 kDa, Protein from Homo sapiens)
40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit e (52 kDa, Protein from Homo sapiens)
40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
Sars-cov-2 nsp1 bound to a human 43s preinitiation ribosome complex - state 2 (Complex)
40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit d (64 kDa, Protein from Homo sapiens)
40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 3 subunit f (37 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 1 (12 kDa, Protein from Homo sapiens)
Trna (24 kDa, RNA from Homo sapiens)
40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)

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