› 7o81

Electron Microscopy
3.1Å resolution

Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot

Released:
DOI: 10.2210/pdb7o81/pdb
PDB entry 7o81 coloured by chain, front view.
PDB entry 7o81 coloured by chain, side view.
PDB entry 7o81 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, Dreos R, O'Connor KM, McMillan A, Bode JW, Thiel V, Gatfield D, Atkins JF, Ban N
Science 372 1306-1313 (2021)
PMID: 34029205
Related structures: EMD-12759

Function and Biology Details

Reactions catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
GTP + a 5'-diphospho-[mRNA] = diphosphate + a 5'-(5'-triphosphoguanosine)-[mRNA]
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 87-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242967 (preferred)
Entry contents:
80 distinct polypeptide molecules
7 distinct RNA molecules
Macromolecules (87 distinct):
Small ribosomal subunit protein eS27 Chain: AA
Molecule details ›
Chain: AA
Length: 84 amino acids
Theoretical weight: 9.48 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TZ76 (Residues: 1-84; Coverage: 100%)
Gene name: RPS27
Sequence domains: Ribosomal protein S27
Small ribosomal subunit protein eS28 Chain: AB
Molecule details ›
Chain: AB
Length: 69 amino acids
Theoretical weight: 7.86 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TIB4 (Residues: 1-69; Coverage: 100%)
Gene name: RPS28
Sequence domains: Ribosomal protein S28e
Ubiquitin-ribosomal protein eS31 fusion protein Chain: AC
Molecule details ›
Chain: AC
Length: 156 amino acids
Theoretical weight: 18 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SK22 (Residues: 50-188; Coverage: 74%)
Gene name: RPS27A
Sequence domains:
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Chain: AD
Molecule details ›
Chain: AD
Length: 133 amino acids
Theoretical weight: 14.5 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T8A2 (Residues: 1-133; Coverage: 100%)
Gene name: FAU
Sequence domains:
Ribosomal protein eS26 Chain: AE
Molecule details ›
Chain: AE
Length: 115 amino acids
Theoretical weight: 13.05 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein RACK1 Chain: AF
Molecule details ›
Chain: AF
Length: 317 amino acids
Theoretical weight: 35.12 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SJB4 (Residues: 117-424; Coverage: 73%)
Gene name: RACK1
Sequence domains: WD domain, G-beta repeat
Small ribosomal subunit protein uS14 Chain: AG
Molecule details ›
Chain: AG
Length: 56 amino acids
Theoretical weight: 6.69 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U7M4 (Residues: 1-56; Coverage: 100%)
Gene name: RPS29
Sequence domains: Ribosomal protein S14p/S29e
EDF1 Chain: AU
Molecule details ›
Chain: AU
Length: 148 amino acids
Theoretical weight: 16.4 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS2 Chain: AZ
Molecule details ›
Chain: AZ
Length: 295 amino acids
Theoretical weight: 32.97 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TLT8 (Residues: 1-295; Coverage: 100%)
Gene name: RPSA
Sequence domains:
Small ribosomal subunit protein eS1 Chain: Aa
Molecule details ›
Chain: Aa
Length: 264 amino acids
Theoretical weight: 30 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SS70 (Residues: 1-264; Coverage: 100%)
Gene name: RPS3A
Sequence domains: Ribosomal S3Ae family
Ribosomal protein uS5 Chain: Ab
Molecule details ›
Chain: Ab
Length: 293 amino acids
Theoretical weight: 31.29 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS3 Chain: Ac
Molecule details ›
Chain: Ac
Length: 281 amino acids
Theoretical weight: 31.15 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TNM3 (Residues: 1-281; Coverage: 100%)
Gene name: RPS3
Sequence domains:
Ribosomal protein eS4 Chain: Ad
Molecule details ›
Chain: Ad
Length: 263 amino acids
Theoretical weight: 29.65 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS7 Chain: Ae
Molecule details ›
Chain: Ae
Length: 204 amino acids
Theoretical weight: 22.91 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TFM5 (Residues: 1-204; Coverage: 100%)
Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein eS6 Chain: Af
Molecule details ›
Chain: Af
Length: 249 amino acids
Theoretical weight: 28.75 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TM55 (Residues: 11-211; Coverage: 81%)
Gene name: RPS6
Sequence domains: Ribosomal protein S6e
Small ribosomal subunit protein eS7 Chain: Ag
Molecule details ›
Chain: Ag
Length: 432 amino acids
Theoretical weight: 47.36 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SVB0 (Residues: 1-432; Coverage: 100%)
Gene name: RPS7
Sequence domains: Ribosomal protein S7e
Small ribosomal subunit protein eS8 Chain: Ah
Molecule details ›
Chain: Ah
Length: 208 amino acids
Theoretical weight: 24.26 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TJW1 (Residues: 1-208; Coverage: 100%)
Gene name: RPS8
Sequence domains: Ribosomal protein S8e
Small ribosomal subunit protein uS4 Chain: Ai
Molecule details ›
Chain: Ai
Length: 194 amino acids
Theoretical weight: 22.64 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: B7NZS8 (Residues: 1-194; Coverage: 100%)
Gene name: RPS9
Sequence domains:
Small ribosomal subunit protein eS10 Chain: Aj
Molecule details ›
Chain: Aj
Length: 165 amino acids
Theoretical weight: 18.93 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TPV3 (Residues: 1-165; Coverage: 100%)
Sequence domains: Plectin/S10 domain
Small ribosomal subunit protein uS17 Chain: Ak
Molecule details ›
Chain: Ak
Length: 158 amino acids
Theoretical weight: 18.47 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TRM4 (Residues: 1-158; Coverage: 100%)
Gene name: RPS11
Sequence domains:
Small ribosomal subunit protein eS12 Chain: Al
Molecule details ›
Chain: Al
Length: 132 amino acids
Theoretical weight: 14.54 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SFR8 (Residues: 1-132; Coverage: 100%)
Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Small ribosomal subunit protein uS15 Chain: Am
Molecule details ›
Chain: Am
Length: 151 amino acids
Theoretical weight: 17.26 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SP51 (Residues: 1-10, 11-152; Coverage: 99%)
Gene name: RPS13
Sequence domains:
Small ribosomal subunit protein uS11 Chain: An
Molecule details ›
Chain: An
Length: 151 amino acids
Theoretical weight: 16.3 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T1F0 (Residues: 1-151; Coverage: 100%)
Gene name: RPS14
Sequence domains: Ribosomal protein S11
Small ribosomal subunit protein uS19 Chain: Ao
Molecule details ›
Chain: Ao
Length: 145 amino acids
Theoretical weight: 17.05 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U0Q2 (Residues: 1-145; Coverage: 100%)
Gene name: RPS15
Sequence domains: Ribosomal protein S19
Small ribosomal subunit protein uS9 Chain: Ap
Molecule details ›
Chain: Ap
Length: 172 amino acids
Theoretical weight: 19.21 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SGX4 (Residues: 1-172; Coverage: 100%)
Gene name: RPS16
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein eS17 Chain: Aq
Molecule details ›
Chain: Aq
Length: 135 amino acids
Theoretical weight: 15.55 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TU13 (Residues: 1-135; Coverage: 100%)
Gene name: RPS17
Sequence domains: Ribosomal S17
Small ribosomal subunit protein uS13 Chain: Ar
Molecule details ›
Chain: Ar
Length: 152 amino acids
Theoretical weight: 17.8 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TPG3 (Residues: 1-152; Coverage: 100%)
Gene name: RPS18
Sequence domains: Ribosomal protein S13/S18
Ribosomal protein eS19 Chain: As
Molecule details ›
Chain: As
Length: 145 amino acids
Theoretical weight: 16.1 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS10 Chain: At
Molecule details ›
Chain: At
Length: 119 amino acids
Theoretical weight: 13.4 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SIZ2 (Residues: 1-119; Coverage: 100%)
Gene name: RPS20
Sequence domains: Ribosomal protein S10p/S20e
Ribosomal protein eS21 Chain: Au
Molecule details ›
Chain: Au
Length: 83 amino acids
Theoretical weight: 9.18 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS8 Chain: Av
Molecule details ›
Chain: Av
Length: 130 amino acids
Theoretical weight: 14.87 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TG89 (Residues: 1-130; Coverage: 100%)
Gene name: RPS15A
Sequence domains: Ribosomal protein S8
Small ribosomal subunit protein uS12 Chain: Aw
Molecule details ›
Chain: Aw
Length: 143 amino acids
Theoretical weight: 15.86 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SZ47 (Residues: 1-143; Coverage: 100%)
Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23
40S ribosomal protein S24 Chain: Ax
Molecule details ›
Chain: Ax
Length: 130 amino acids
Theoretical weight: 15.11 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T3D8 (Residues: 1-130; Coverage: 99%)
Sequence domains: Ribosomal protein S24e
Small ribosomal subunit protein eS25 Chain: Ay
Molecule details ›
Chain: Ay
Length: 124 amino acids
Theoretical weight: 13.65 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TDB3 (Residues: 1-124; Coverage: 100%)
Gene name: RPS25
Sequence domains: S25 ribosomal protein
Small ribosomal subunit protein eS32 Chain: Az
Molecule details ›
Chain: Az
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: A0A087WNH4 (Residues: 1-25; Coverage: 100%)
Gene name: RPL41
Sequence domains: Ribosomal protein L41
Ribosomal protein uL2 Chain: BA
Molecule details ›
Chain: BA
Length: 257 amino acids
Theoretical weight: 28.1 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL3 Chain: BB
Molecule details ›
Chain: BB
Length: 403 amino acids
Theoretical weight: 46.12 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TL06 (Residues: 1-403; Coverage: 100%)
Gene name: RPL3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4 Chain: BC
Molecule details ›
Chain: BC
Length: 413 amino acids
Theoretical weight: 46.43 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SVW5 (Residues: 1-413; Coverage: 100%)
Gene name: RPL4
Sequence domains:
Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein Chain: BD
Molecule details ›
Chain: BD
Length: 297 amino acids
Theoretical weight: 34.52 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SYJ6 (Residues: 1-297; Coverage: 100%)
Sequence domains:
Large ribosomal subunit protein eL6 Chain: BE
Molecule details ›
Chain: BE
Length: 291 amino acids
Theoretical weight: 33.03 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SKF7 (Residues: 1-291; Coverage: 100%)
Gene name: RPL6
Sequence domains:
Ribosomal Protein uL30 Chain: BF
Molecule details ›
Chain: BF
Length: 247 amino acids
Theoretical weight: 29.2 KDa
Source organism: Oryctolagus cuniculus
Ribosomal protein eL8 Chain: BG
Molecule details ›
Chain: BG
Length: 266 amino acids
Theoretical weight: 30.06 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL6 Chain: BH
Molecule details ›
Chain: BH
Length: 192 amino acids
Theoretical weight: 21.87 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SWI6 (Residues: 1-192; Coverage: 100%)
Gene name: RPL9
Sequence domains: Ribosomal protein L6
Large ribosomal subunit protein uL16 Chain: BI
Molecule details ›
Chain: BI
Length: 214 amino acids
Theoretical weight: 24.64 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: B7NZQ2 (Residues: 1-214; Coverage: 100%)
Gene name: RPL10
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL5 Chain: BJ
Molecule details ›
Chain: BJ
Length: 178 amino acids
Theoretical weight: 20.29 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TUB8 (Residues: 1-178; Coverage: 100%)
Gene name: RPL11
Sequence domains:
RNA-directed RNA polymerase nsp12 Chain: BK
Molecule details ›
Chain: BK
Length: 1071 amino acids
Theoretical weight: 121.57 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Oryctolagus cuniculus
UniProt:
  • Canonical: P0DTD1 (Residues: 4254-5324; Coverage: 15%)
Gene names: 1a-1b, rep
Sequence domains:
Ribosomal protein eL13 Chain: BL
Molecule details ›
Chain: BL
Length: 211 amino acids
Theoretical weight: 24.33 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL14 Chain: BM
Molecule details ›
Chain: BM
Length: 218 amino acids
Theoretical weight: 23.87 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SZ12 (Residues: 1-218; Coverage: 100%)
Gene name: RPL14
Sequence domains: Ribosomal protein L14
Large ribosomal subunit protein eL15 Chain: BN
Molecule details ›
Chain: BN
Length: 204 amino acids
Theoretical weight: 24.21 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T0C1 (Residues: 1-204; Coverage: 100%)
Gene name: RPL15
Sequence domains: Ribosomal L15
Ribosomal protein L13a Chain: BO
Molecule details ›
Chain: BO
Length: 203 amino acids
Theoretical weight: 23.53 KDa
Source organism: Oryctolagus cuniculus
uL22 Chain: BP
Molecule details ›
Chain: BP
Length: 184 amino acids
Theoretical weight: 21.44 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TVT6 (Residues: 1-213; Coverage: 86%)
Sequence domains: Ribosomal protein L22p/L17e
Ribosomal protein L18 Chain: BQ
Molecule details ›
Chain: BQ
Length: 188 amino acids
Theoretical weight: 21.7 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL19 Chain: BR
Molecule details ›
Chain: BR
Length: 196 amino acids
Theoretical weight: 23.54 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: Q3T0W9 (Residues: 1-196; Coverage: 100%)
Gene name: RPL19
Sequence domains: Ribosomal protein L19e
Ribosomal protein L18a Chain: BS
Molecule details ›
Chain: BS
Length: 176 amino acids
Theoretical weight: 20.75 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL21 Chain: BT
Molecule details ›
Chain: BT
Length: 160 amino acids
Theoretical weight: 18.61 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SHQ2 (Residues: 1-160; Coverage: 100%)
Gene name: RPL21
Sequence domains: Ribosomal protein L21e
Ribosomal protein eL22 Chain: BU
Molecule details ›
Chain: BU
Length: 128 amino acids
Theoretical weight: 14.76 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL14 Chain: BV
Molecule details ›
Chain: BV
Length: 140 amino acids
Theoretical weight: 14.89 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T6D1 (Residues: 1-140; Coverage: 100%)
Gene name: RPL23
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein eL24 Chain: BW
Molecule details ›
Chain: BW
Length: 157 amino acids
Theoretical weight: 17.83 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SE28 (Residues: 1-157; Coverage: 100%)
Gene name: RPL24
Sequence domains: Ribosomal protein L24e
Large ribosomal subunit protein uL23 Chain: BX
Molecule details ›
Chain: BX
Length: 156 amino acids
Theoretical weight: 17.77 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SE76 (Residues: 1-156; Coverage: 100%)
Gene name: RPL23A
Sequence domains:
Large ribosomal subunit protein uL24 Chain: BY
Molecule details ›
Chain: BY
Length: 145 amino acids
Theoretical weight: 17.3 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SQH0 (Residues: 1-145; Coverage: 100%)
Gene name: RPL26
Sequence domains:
Large ribosomal subunit protein eL27 Chain: BZ
Molecule details ›
Chain: BZ
Length: 136 amino acids
Theoretical weight: 15.84 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TXF6 (Residues: 1-136; Coverage: 100%)
Gene name: RPL27
Sequence domains:
Large ribosomal subunit protein uL15 Chain: Ba
Molecule details ›
Chain: Ba
Length: 148 amino acids
Theoretical weight: 16.64 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SNY0 (Residues: 1-148; Coverage: 100%)
Gene name: RPL27A
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL29 Chain: Bb
Molecule details ›
Chain: Bb
Length: 245 amino acids
Theoretical weight: 26.72 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SGR6 (Residues: 1-245; Coverage: 100%)
Gene name: RPL29
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL30 Chain: Bc
Molecule details ›
Chain: Bc
Length: 115 amino acids
Theoretical weight: 12.81 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TDL2 (Residues: 1-115; Coverage: 100%)
Gene name: RPL30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL31 Chain: Bd
Molecule details ›
Chain: Bd
Length: 125 amino acids
Theoretical weight: 14.49 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SHG0 (Residues: 1-125; Coverage: 100%)
Gene name: RPL31
Sequence domains: Ribosomal protein L31e
Large ribosomal subunit protein eL32 Chain: Be
Molecule details ›
Chain: Be
Length: 135 amino acids
Theoretical weight: 15.9 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TUN8 (Residues: 23-157; Coverage: 86%)
Gene name: RPL32
Sequence domains: Ribosomal protein L32
Large ribosomal subunit protein eL33 Chain: Bf
Molecule details ›
Chain: Bf
Length: 110 amino acids
Theoretical weight: 12.58 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SF08 (Residues: 1-110; Coverage: 100%)
Gene name: RPL35A
Sequence domains: Ribosomal protein L35Ae
Large ribosomal subunit protein eL34 Chain: Bg
Molecule details ›
Chain: Bg
Length: 117 amino acids
Theoretical weight: 13.33 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TXG5 (Residues: 1-117; Coverage: 100%)
Gene name: RPL34
Sequence domains: Ribosomal protein L34e
Large ribosomal subunit protein uL29 Chain: Bh
Molecule details ›
Chain: Bh
Length: 123 amino acids
Theoretical weight: 14.57 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SIT5 (Residues: 1-123; Coverage: 100%)
Gene name: RPL35
Sequence domains: Ribosomal L29 protein
Large ribosomal subunit protein eL36 Chain: Bi
Molecule details ›
Chain: Bi
Length: 105 amino acids
Theoretical weight: 12.26 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TTQ5 (Residues: 26-99; Coverage: 75%)
Gene name: RPL36
Sequence domains: Ribosomal protein L36e
Large ribosomal subunit protein eL37 Chain: Bj
Molecule details ›
Chain: Bj
Length: 97 amino acids
Theoretical weight: 11.11 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: U3KPD5 (Residues: 1-97; Coverage: 100%)
Gene name: RPL37
Sequence domains: Ribosomal protein L37e
Large ribosomal subunit protein eL38 Chain: Bk
Molecule details ›
Chain: Bk
Length: 70 amino acids
Theoretical weight: 8.24 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U001 (Residues: 1-70; Coverage: 100%)
Gene name: RPL38
Sequence domains: Ribosomal L38e protein family
Large ribosomal subunit protein eL39 Chain: Bl
Molecule details ›
Chain: Bl
Length: 51 amino acids
Theoretical weight: 6.46 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TTN1 (Residues: 1-51; Coverage: 100%)
Sequence domains: Ribosomal L39 protein
60S ribosomal protein L40 Chain: Bm
Molecule details ›
Chain: Bm
Length: 128 amino acids
Theoretical weight: 14.8 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL42 Chain: Bo
Molecule details ›
Chain: Bo
Length: 106 amino acids
Theoretical weight: 12.49 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T040 (Residues: 1-100; Coverage: 90%)
Gene name: RPL36A
Sequence domains: Ribosomal protein L44
Large ribosomal subunit protein eL43 Chain: Bp
Molecule details ›
Chain: Bp
Length: 92 amino acids
Theoretical weight: 10.3 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SY53 (Residues: 1-92; Coverage: 100%)
Gene name: RPL37A
Sequence domains: Ribosomal L37ae protein family
Ribosomal protein eL28 Chain: Br
Molecule details ›
Chain: Br
Length: 137 amino acids
Theoretical weight: 15.84 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL10 Chain: Bs
Molecule details ›
Chain: Bs
Length: 318 amino acids
Theoretical weight: 34.38 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SPK4 (Residues: 1-318; Coverage: 100%)
Gene name: RPLP0
Sequence domains:
Large ribosomal subunit protein uL11 Chain: Bt
Molecule details ›
Chain: Bt
Length: 165 amino acids
Theoretical weight: 17.85 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SMR7 (Residues: 1-165; Coverage: 100%)
Gene name: RPL12
Sequence domains:
Large ribosomal subunit protein uL1 Chain: Bv
Molecule details ›
Chain: Bv
Length: 217 amino acids
Theoretical weight: 24.88 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SKZ8 (Residues: 1-217; Coverage: 100%)
Gene name: RPL10A
Sequence domains: Ribosomal protein L1p/L10e family
18S Ribosomal RNA Chain: A2
Molecule details ›
Chain: A2
Length: 1870 nucleotides
Theoretical weight: 603.93 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA
mRNA containing SARS-CoV-2 sequence Chain: AH
Molecule details ›
Chain: AH
Length: 217 nucleotides
Theoretical weight: 69.68 KDa
Sequence domains: Coronavirus frameshifting stimulation element
A-site Met-tRNA(Met) Chain: AJ
Molecule details ›
Chain: AJ
Length: 76 nucleotides
Theoretical weight: 24.47 KDa
Sequence domains: tRNA
P-site tRNA(Pro) Chain: AT
Molecule details ›
Chain: AT
Length: 75 nucleotides
Theoretical weight: 24.2 KDa
Sequence domains: tRNA
28S ribosomal RNA Chain: B5
Molecule details ›
Chain: B5
Length: 4808 nucleotides
Theoretical weight: 1557.52 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
5S ribosomal RNA Chain: B7
Molecule details ›
Chain: B7
Length: 120 nucleotides
Theoretical weight: 38.85 KDa
Sequence domains: 5S ribosomal RNA
5.8S ribosomal RNA Chain: B8
Molecule details ›
Chain: B8
Length: 158 nucleotides
Theoretical weight: 50.81 KDa
Sequence domains: 5.8S ribosomal RNA

Ligands and Environments

4 bound ligands:
Ligand MG 349 x MG
Ligand UNX 266 x UNX
Ligand ZN 8 x ZN
Ligand SPD 1 x SPD
21 modified residues:
Ligand A2M 33 x A2M
Ligand PSU 98 x PSU
Ligand OMU 17 x OMU
Ligand OMC 20 x OMC
Ligand OMG 30 x OMG
Ligand G7M 1 x G7M
Ligand 6MZ 2 x 6MZ
Ligand MA6 2 x MA6
Ligand 5MU 2 x 5MU
Ligand SAC 3 x SAC
Ligand NMM 1 x NMM
Ligand HY3 1 x HY3
Ligand 1MA 1 x 1MA
Ligand 5MC 2 x 5MC
Ligand UR3 1 x UR3
Ligand GTP 1 x GTP
Ligand V5N 2 x V5N
Ligand HIC 1 x HIC
Ligand AYA 1 x AYA
Ligand MLZ 2 x MLZ
Ligand M3L 1 x M3L

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-12759
Expression system: Oryctolagus cuniculus

Quick links

Citations

38 review citations

Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design.
Malone et al. (2022)
37 more