Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in inactivated conformation (Dataset-A)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7tdg
Q-score: 0.386
eLife (2022) 11 [ Pubmed: 35257661 DOI: doi:10.7554/eLife.75568 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Rabbit ryr1 with amp-pcp and high ca2+ in nanodisc (2 MDa, Complex from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 1,ryr1 (533 kDa, Protein from rabbit)
Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in open conformation
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7tdh
Q-score: 0.215
eLife (2022) 11 [ Pubmed: 35257661 DOI: doi:10.7554/eLife.75568 ]
- Rabbit ryr1 with amp-pcp and high ca2+ in nanodisc (2 MDa, Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1,ryanodine receptor 1,ryr1 (533 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7tdi
Q-score: 0.332
eLife (2022) 11 [ Pubmed: 35257661 DOI: doi:10.7554/eLife.75568 ]
- Rabbit ryr1 with amp-pcp and high ca2+ in nanodisc (2 MDa, Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1,ryanodine receptor 1,ryr1 (533 kDa, Protein from rabbit)
- Calcium ion (40 Da, Ligand)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7tdj
Q-score: 0.365
eLife (2022) 11 [ Pubmed: 35257661 DOI: doi:10.7554/eLife.75568 ]
- Rabbit ryr1 with amp-pcp and high ca2+ in nanodisc (2 MDa, Complex from Oryctolagus cuniculus)
- Water (18 Da, Ligand)
- Ryanodine receptor 1,ryanodine receptor 1,ryr1 (533 kDa, Protein from rabbit)
- Calcium ion (40 Da, Ligand)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7tdk
Q-score: 0.357
eLife (2022) 11 [ Pubmed: 35257661 DOI: doi:10.7554/eLife.75568 ]
- Rabbit ryr1 with amp-pcp and high ca2+ in nanodisc (2 MDa, Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1,ryanodine receptor 1,ryr1 (533 kDa, Protein from rabbit)
- Calcium ion (40 Da, Ligand)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of rabbit RyR1 in the presence of AMP-PCP in nanodisc
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7k0t
Q-score: 0.332
eLife (2022) 11 [ Pubmed: 35257661 DOI: doi:10.7554/eLife.75568 ]
- Zinc ion (65 Da, Ligand)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- Ryr1 (533 kDa, Protein from Oryctolagus cuniculus)
- Rabbit ryr1 with amp-pcp (2 MDa, Complex from Oryctolagus cuniculus)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6wot
Q-score: 0.32
Iyer KA, Hu Y, Nayak AR, Kurebayashi N, Murayama T, Samso M
Sci Adv (2020) 6 pp. eabb2964-eabb2964 [ Pubmed: 32832689 DOI: doi:10.1126/sciadv.abb2964 ]
- Recombinant rabbit ryanodine receptor type 1, ryr1, with mutation r164c in complex with fkbp12.6 (2 MDa, Complex)
- Zinc ion (65 Da, Ligand)
- Fkbp12.6 (Complex from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Recombinant rabbit ryanodine receptor type 1, ryr1, with mutation r164c (Complex from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 6wou
Q-score: 0.376
Iyer KA, Hu Y, Nayak AR, Kurebayashi N, Murayama T, Samso M
Sci Adv (2020) 6 pp. eabb2964-eabb2964 [ Pubmed: 32832689 DOI: doi:10.1126/sciadv.abb2964 ]
- Ryanodine receptor 2 (565 kDa, Protein from Mus musculus)
- Fkbp12.6 (Complex from Homo sapiens)
- Recombinant mouse ryanodine receptor type 2, ryr2, with mutation r176q in complex with fkbp12.6 (2 MDa, Complex)
- Zinc ion (65 Da, Ligand)
- Recombinant mouse ryanodine receptor type 2, ryr2, with mutation r176q (Complex from Mus musculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of recombinant mouse Ryanodine Receptor type 2 wild type in complex with FKBP12.6
Resolution: 5.1 Å
EM Method: Single-particle
Fitted PDBs: 6wov
Q-score: 0.133
Iyer KA, Hu Y, Nayak AR, Kurebayashi N, Murayama T, Samso M
Sci Adv (2020) 6 pp. eabb2964-eabb2964 [ Pubmed: 32832689 DOI: doi:10.1126/sciadv.abb2964 ]
- Recombinant mouse ryanodine receptor type 2, ryr2, wild type in complex with fkbp12.6 (2 MDa, Complex)
- Fkbp12.6 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Mus musculus)
- Recombinant mouse ryanodine receptor type 2, ryr2, wild type (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)