Cryo-EM structure of human gamma-secretase in complex with Abeta49
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x52
Q-score: 0.464
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ Pubmed: 38843321 DOI: doi:10.1126/science.adn5820 ]
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Amyloid-beta precursor protein (13 kDa, Protein from Homo sapiens)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Human gamma-secretase in complex with abeta49 (Complex from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human gamma-secretase in complex with Abeta46
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x53
Q-score: 0.509
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ Pubmed: 38843321 DOI: doi:10.1126/science.adn5820 ]
- Nicastrin (78 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Amyloid-beta precursor protein (4 kDa, Protein from Homo sapiens)
- Human gamma-secretase in complex with abeta46 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Gamma-secretase subunit pen-2 (16 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human gamma-secretase in complex with APP-C99
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x54
Q-score: 0.518
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ Pubmed: 38843321 DOI: doi:10.1126/science.adn5820 ]
- Human gamma-secretase in complex with app-c99 (Complex from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Amyloid-beta precursor protein (13 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8v6u
Q-score: 0.54
Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Alvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL
Science (2024) pp. eadn6354-eadn6354 [ Pubmed: 38753765 DOI: doi:10.1126/science.adn6354 ]
- G protein alpha-subunit q (gi2-mini-gq chimera) (28 kDa, Protein from Homo sapiens)
- 5-hydroxytryptamine receptor 2a (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 4-{(3r)-1-[(1r)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol (283 Da, Ligand)
- Active state complex of 5ht2ar with mini-gq heterotrimer stabilized by scfv16 (Complex from Homo sapiens)
- Single-chain variable fragment 16 (scfv16) (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8t4k
Q-score: 0.62
Steichen JM, Phung I, Salcedo E, Ozorowski G, Willis JR, Baboo S, Liguori A, Cottrell CA, Torres JL, Madden PJ, Ma KM, Sutton HJ, Lee JH, Kalyuzhniy O, Allen JD, Rodriguez OL, Adachi Y, Mullen TM, Georgeson E, Kubitz M, Burns A, Barman S, Mopuri R, Metz A, Altheide TK, Diedrich JK, Saha S, Shields K, Schultze SE, Smith ML, Schiffner T, Burton DR, Watson CT, Bosinger SE, Crispin M, Yates 3rd JR, Paulson JC, Ward AB, Sok D, Crotty S, Schief WR
Science (2024) 384 pp. eadj8321-eadj8321 [ Pubmed: 38753769 DOI: doi:10.1126/science.adj8321 ]
- Md64 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Md64 n332-gt5 sosip (Complex from Human immunodeficiency virus 1)
- Md64 n332-gt5 sosip gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Asymetric subunit of E. coli DNA gyrase bound to a linear part of a DNA minicircle
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8qqu
Q-score: 0.542
Vayssieres M, Marechal N, Yun L, Lopez Duran B, Murugasamy NK, Fogg JM, Zechiedrich L, Nadal M, Lamour V
Science (2024) 384 pp. 227-232 [ DOI: doi:10.1126/science.adl5899 Pubmed: 38603484 ]
- E. coli dna gyrase in complex with dsdna minicircles (745 kDa, Complex)
- Dna gyrase subunit b (90 kDa, Protein from Escherichia coli)
- Dsdna minicircles (Complex from synthetic construct)
- Dna (16-mer) (4 kDa, DNA from synthetic construct)
- Dna gyrase subunit a (97 kDa, Protein from Escherichia coli)
- Dna (16-mer) (4 kDa, DNA from synthetic construct)
- E. coli dna gyrase (Complex from Escherichia coli)
Structure of the undecorated barbed end of F-actin.
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8ru0
Q-score: 0.542
Oosterheert W, Boiero Sanders M, Funk J, Prumbaum D, Raunser S, Bieling P
Science (2024) 384 pp. eadn9560-eadn9560 [ Pubmed: 38603491 DOI: doi:10.1126/science.adn9560 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Actin filament (Complex)
- Complex of the actin subunits that form the barbed end of actin filaments. (Complex from Oryctolagus cuniculus)
- Phosphate ion (94 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Actin, alpha skeletal muscle (41 kDa, Protein from Oryctolagus cuniculus)
Structure of the wild-type Arabidopsis ABCB19 in the apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8woi
Q-score: 0.49
Ying W, Wang Y, Wei H, Luo Y, Ma Q, Zhu H, Janssens H, Vukasinovic N, Kvasnica M, Winne JM, Gao Y, Tan S, Friml J, Liu X, Russinova E, Sun L
Science (2024) 383 pp. eadj4591-eadj4591 [ Pubmed: 38513023 DOI: doi:10.1126/science.adj4591 ]
Structure of the wild-type Arabidopsis ABCB19 in the brassinolide-bound state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8wom
Q-score: 0.451
Ying W, Wang Y, Wei H, Luo Y, Ma Q, Zhu H, Janssens H, Vukasinovic N, Kvasnica M, Winne JM, Gao Y, Tan S, Friml J, Liu X, Russinova E, Sun L
Science (2024) 383 pp. eadj4591-eadj4591 [ Pubmed: 38513023 DOI: doi:10.1126/science.adj4591 ]
Structure of the wild-type Arabidopsis ABCB19 in the brassinolide and AMP-PNP bound state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8woo
Q-score: 0.401
Ying W, Wang Y, Wei H, Luo Y, Ma Q, Zhu H, Janssens H, Vukasinovic N, Kvasnica M, Winne JM, Gao Y, Tan S, Friml J, Liu X, Russinova E, Sun L
Science (2024) 383 pp. eadj4591-eadj4591 [ Pubmed: 38513023 DOI: doi:10.1126/science.adj4591 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Abc transporter b family member 19 (136 kDa, Protein from Arabidopsis thaliana)
- Purified wild-type abcb19 protein in complex with brassinolide and amp-pnp (Cellular component from Arabidopsis thaliana)
- Magnesium ion (24 Da, Ligand)
- Brassinolide (480 Da, Ligand)