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Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to YPEL5
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8qbn
Q-score: 0.581
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu T, Karayel O, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi A
To Be Published
- Wd repeat-containing protein 26 (70 kDa, Protein from Homo sapiens)
- Protein yippee-like 5 (13 kDa, Protein from Homo sapiens)
- Complex of human wdr26-ctlh e3 ligase bound to ypel5 (900 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8fy8
Q-score: 0.519
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- 2-(5-methoxy-1h-indol-3-yl)-n,n-dimethylethan-1-amine (218 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8fye
Q-score: 0.53
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1h-indole (262 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8fyl
Q-score: 0.525
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide (441 Da, Ligand)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8fyt
Q-score: 0.544
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8fyx
Q-score: 0.545
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Buspirone (385 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
DltB tetramer in complex with inhibitor m-AMSA
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8jem
Q-score: 0.502
Nat Commun (2024) 15 pp. 3404-3404 [ DOI: doi:10.1038/s41467-024-47783-7 Pubmed: 38649359 ]
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Diacyl glycerol (625 Da, Ligand)
- N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide (393 Da, Ligand)
- Dltb tetramer in complex with inhibitor m-amsa. (48 MDa, Complex from Streptococcus thermophilus)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Teichoic acid d-alanyltransferase (51 kDa, Protein from Streptococcus thermophilus LMG 18311)
Human GPR34 -Gi complex bound to S3E-LysoPS
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xbe
Q-score: 0.445
Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 902-902 [ DOI: doi:10.1038/s41467-024-45046-z Pubmed: 38326347 ]
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- (2~{s})-2-azanyl-3-[[(2~{r})-1-ethoxy-3-[(~{z})-octadec-9-enoyl]oxy-propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid (551 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Probable g-protein coupled receptor 34 (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Human gpr34-gi complex bound to s3e-lysops (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Probable g-protein coupled receptor 34 (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium 37 degrees Celsius
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9b8z
Q-score: 0.451
Hu J, Park SJ, Walter T, Orozco IJ, O'Dea G, Ye X, Du J, Lu W
Nature (2024) [ DOI: doi:10.1038/s41586-024-07436-7 ]
- Human trpm4 channel subunit in complex with calcium and decavanadate at 37 degrees celsius (Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (134 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Decavanadate (957 Da, Ligand)