The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators.
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6muv
Q-score: 0.397
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ Pubmed: 31384003 DOI: doi:10.1038/s41564-019-0524-4 ]
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Proteasome activator pa28 (33 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 11s activator of the plasmodium falciparum proteasome. (Complex from Plasmodium falciparum 3D7)
- 20s proteasome/pa28 complex. (230 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Plasmodium falciparum 20s proteasome (Complex from Plasmodium falciparum 3D7)
The structure of the Plasmodium falciparum 20S proteasome.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6muw
Q-score: 0.461
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ Pubmed: 31384003 DOI: doi:10.1038/s41564-019-0524-4 ]
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome/pa28 complex. (760 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator.
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6mux
Q-score: 0.439
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ Pubmed: 31384003 DOI: doi:10.1038/s41564-019-0524-4 ]
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 11s activator of the plasmodium falciparum proteasome. (Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome/pa28 complex. (230 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome activator pa28 (33 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome (Complex from Plasmodium falciparum 3D7)
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum 3D7)
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ Pubmed: 31384003 DOI: doi:10.1038/s41564-019-0524-4 ]