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PTHrP-bound human PTH1R in complex with Gs
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7vvj
Q-score: 0.518
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ DOI: doi:10.1016/j.molcel.2022.07.003 Pubmed: 35932760 ]
- Pthrp[1-36] (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (55 kDa, Protein from Homo sapiens)
- Nanobody nb35 (Complex)
- Pthrp (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
PTH-bound human PTH1R in complex with Gs (class1)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vvk
Q-score: 0.444
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ DOI: doi:10.1016/j.molcel.2022.07.003 Pubmed: 35932760 ]
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Parathyroid hormone (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
PTH-bound human PTH1R in complex with Gs (class2)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7vvl
Q-score: 0.54
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ DOI: doi:10.1016/j.molcel.2022.07.003 Pubmed: 35932760 ]
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Parathyroid hormone (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Water (18 Da, Ligand)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
PTH-bound human PTH1R in complex with Gs (class3)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7vvm
Q-score: 0.454
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ DOI: doi:10.1016/j.molcel.2022.07.003 Pubmed: 35932760 ]
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Parathyroid hormone (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
PTH-bound human PTH1R in complex with Gs (class4)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7vvn
Q-score: 0.405
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ DOI: doi:10.1016/j.molcel.2022.07.003 Pubmed: 35932760 ]
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Parathyroid hormone (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
PTH-bound human PTH1R in complex with Gs (class5)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7vvo
Q-score: 0.359
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ DOI: doi:10.1016/j.molcel.2022.07.003 Pubmed: 35932760 ]
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Nanobody nb35 (Complex)
- Pthrp (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)