Cryo electron-microscopy of TMEM106B fibrils extracted from four FTLD-TDP patient brains
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Loo RR, Loo JA, Eisenberg DS
Nature (2022) [ Pubmed: 35344984 DOI: 10.1038/s41586-022-04670-9 ]
Image sets:
- Unaligned multi-frame micrographs of TMEM106B amyloid fibrils extracted from FTLD-TDP donor 1
- Unaligned multi-frame micrographs of TMEM106B amyloid fibrils extracted from FTLD-TDP donor 3
- Unaligned multi-frame micrographs of TMEM106B amyloid fibrils extracted from FTLD-TDP donor 4
- Unaligned multi-frame micrographs of TMEM106B amyloid fibrils extracted from FTLD-TDP donor 2
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1
Resolution: 2.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 7saq
Q-score: 0.541
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Ogorzalek Loo RR, Loo JA, Eisenberg DS
Nature (2022) 605 pp. 304-309 [ Pubmed: 35344984 DOI: doi:10.1038/s41586-022-04670-9 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Tmem106b fibrils, polymorph 1 (Cellular component from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from Human)
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 7sar
Q-score: 0.499
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Ogorzalek Loo RR, Loo JA, Eisenberg DS
Nature (2022) 605 pp. 304-309 [ Pubmed: 35344984 DOI: doi:10.1038/s41586-022-04670-9 ]
- Transmembrane protein 106b (31 kDa, Protein from Human)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Tmem106b fibrils, polymorph 2 (Cellular component from Homo sapiens)
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3
Resolution: 3.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 7sas
Q-score: 0.439
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Ogorzalek Loo RR, Loo JA, Eisenberg DS
Nature (2022) 605 pp. 304-309 [ Pubmed: 35344984 DOI: doi:10.1038/s41586-022-04670-9 ]
- Tmem106b fibrils, polymorph 3 (Cellular component from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Transmembrane protein 106b (31 kDa, Protein from Human)
Jiang J, Chan H, Cash DD, Miracco EJ, Ogorzalek Loo RR, Upton HE, Cascio D, O'Brien Johnson R, Collins K, Loo JA, Zhou ZH, Feigon J
Science (2015) 350 [ DOI: doi:10.1126/science.aab4070 Pubmed: 26472759 ]
- Telomerase holoenzyme from tetrahymena thermophila (560 kDa, Sample)
- Telomerase holoenzyme (560 kDa, Protein from Tetrahymena thermophila)
Jiang J, Chan H, Cash DD, Miracco EJ, Ogorzalek Loo RR, Upton HE, Cascio D, O'Brien Johnson R, Collins K, Loo JA, Zhou ZH, Feigon J
Science (2015) 350 [ DOI: doi:10.1126/science.aab4070 Pubmed: 26472759 ]
- Telomerase holoenzyme from tetrahymena thermophila (560 kDa, Sample)
- Telomerase holoenzyme (560 kDa, Protein from Tetrahymena thermophila)