Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research.

EMD-24955

Helical reconstruction
3.7 Å
EMD-24955
3D View Gallery
Deposition: 23/09/2021
Map released: 09/03/2022
Last modified: 25/05/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-24955
Download
3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7sas summary report (pdf.gz) Map and 7sas FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3

EMD-24955

Helical reconstruction
3.7 Å
EMD-24955
3D View Gallery
Deposition: 23/09/2021
Map released: 09/03/2022
Last modified: 25/05/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Human
Sample: TMEM106B fibrils, polymorph 3
Fitted models: 7sas

Deposition Authors: Cao Q , Jiang Y , Sawaya MR , Eisenberg DS
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Jiang YX , Cao Q , Sawaya MR , Abskharon R, Ge P , DeTure M, Dickson DW , Fu JY , Ogorzalek Loo RR, Loo JA , Eisenberg DS
(2022) Nature , 605 , 304 - 309
PUBMED: 35344984
DOI: doi:10.1038/s41586-022-04670-9
ISSN: 1476-4687
ASTM: NATUAS