EMD-47338

Single-particle
2.72 Å
EMD-47338
Deposition: 17/10/2024
Map released: 05/02/2025
Obsolete date: 14/01/2026
Last modified: 14/01/2026
Overview

EMD-47338

 This entry was superseded by EMD-70618.

Cryo-EM structure of the C. neoformans lipid flippase Apt1-Cdc50 bound with butyrolactol A in the E2P state

EMD-47338

Single-particle
2.72 Å
EMD-47338
Deposition: 17/10/2024
Map released: 05/02/2025
Obsolete date: 14/01/2026
Last modified: 14/01/2026
Sample Organism: Cryptococcus neoformans var. grubii H99
Sample: Apt1-Cdc50 heterodimer bound with butyrolactol A
Fitted models: 9dzu

Deposition Authors: Duan HD, Li H
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.
Chen X, Duan HD, Hoy MJ, Koteva K, Spitzer M, Guitor AK, Puumala E, Fiebig AA, Hu G, Yiu B, Chou S, Bian Z, Choi Y, Guo ABY, Wang W, Sun S, Robbins N, Averette AF, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Coombes BK, Cowen LE, Heitman J, Li H, Wright GD
(2025) Cell
PUBMED: 41478284
DOI: doi:10.1016/j.cell.2025.11.036
ISSN: 1097-4172