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EMD-22493
Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein
EMD-22493
Single-particle3.0 Å
Deposition: 20/08/2020Map released: 24/02/2021
Last modified: 28/05/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: SKF-81297-bound dopamine receptor 1 in complex with Gi protein
Fitted models: 7jv5
Deposition Authors: Zhuang Y
,
Xu P
Sample: SKF-81297-bound dopamine receptor 1 in complex with Gi protein
Fitted models: 7jv5
Deposition Authors: Zhuang Y
,
Xu P
Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Zhuang Y ,
Xu P,
Mao C ,
Wang L,
Krumm B,
Zhou XE,
Huang S,
Liu H,
Cheng X ,
Huang XP,
Shen DD,
Xu T,
Liu YF,
Wang Y,
Guo J,
Jiang Y,
Jiang H,
Melcher K ,
Roth BL ,
Zhang Y,
Zhang C,
Xu HE
(2021) Cell , 184 , 931 - 942.e18
,
Xu P,
Mao C ,
Wang L,
Krumm B,
Zhou XE,
Huang S,
Liu H,
Cheng X ,
Huang XP,
Shen DD,
Xu T,
Liu YF,
Wang Y,
Guo J,
Jiang Y,
Jiang H,
Melcher K ,
Roth BL ,
Zhang Y,
Zhang C,
Xu HE
(2021) Cell , 184 , 931 - 942.e18
Grant Support:
- National Natural Science Foundation of China (NSFC): 81922071 (China)
- National Natural Science Foundation of China (NSFC): 31770796 (China)
- National Institutes of Health/National Institute of Mental Health (NIH/NIMH): RO1MH112205 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM128641 (United States)