Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

Edit your search query here and hit Return to execute it:
sample_name:"UBR5"

Filter By

Current Database

  • EMDB [14]

Current status

  • REL [14]

Sample type

  • Complex [13]
  • Protein [10]
  • Ligand [7]
  • Cellular component [1]

Organism

  • Homo sapiens [14]

EM Method

  • Single-particle [14]

Resolution

  • ≥ 2Å and < 3Å [3]
  • ≥ 3Å and < 4Å [6]
  • ≥ 4Å and < 5Å [1]
  • ≥ 5Å and < 6Å [1]
  • ≥ 6Å and < 8Å [1]
  • ≥ 8Å and < 12Å [1]
  • ≥ 20Å and < 30Å [1]

Model molecular weight

  • 500-1000 kDa [5]
  • 1-2 MDa [3]

Release Date

  • 2023 [14]

Author by name

  • Hehl LA [6]
  • Horn-ghetko D [6]
  • Mulder MPC [6]
  • Perez Berrocal Da [6]
  • Prabu JR [6]
  • Schulman BA [6]
  • Vollrath R [6]
  • Vu DT [6]
  • Van Der Heden Van Noort Gj [6]
  • Aguirre JD [4]
  • Kater L [4]
  • Kempf G [4]
  • Schmitt S [4]
  • Thoma NH [4]
  • Armstrong SA [3]
  • Belizaire R [3]
  • Brown J [3]
  • Cavadini S [3]
  • Cutler JA [3]
  • Donovan KA [3]
  • Ebert BL [3]
  • Ener E [3]
  • Finkin-groner E [3]
  • Fischer ES [3]
  • Focht V [3]
  • Galli P [3]
  • Hatton C [3]
  • He Q [3]
  • Irizarry R [3]
  • Kim J [3]
  • Li H [3]
  • Li YD [3]
  • Lin G [3]
  • Lumpkin RJ [3]
  • Ma X [3]
  • Miller PG [3]
  • Park PMC [3]
  • Regalado BD [3]
  • Rutter JC [3]
  • Sandate CR [3]
  • Sandoval B [3]
  • Sievers Q [3]
  • Slabicki M [3]
  • Sperling AS [3]
  • Sperling MT [3]
  • Tsai JM [3]
  • Wang F [3]
  • Yu Z [3]
  • Zhan W [3]
  • Zhang Z [3]
  • Zon R [3]
  • Zou C [3]
  • Akopian D [1]
  • Belacic K [1]
  • Bolhuis DL [1]
  • Brown NG [1]
  • Brunner HL [1]
  • Garshott DM [1]
  • Grishkovskaya I [1]
  • Haakonsen DL [1]
  • Haselbach D [1]
  • Hodakova Z [1]
  • Kolla S [1]
  • Kotisch H [1]
  • Mark KG [1]
  • Martinez-gonzalez B [1]
  • Rape M [1]
  • Schleiffer A [1]
  • See SK [1]
  • Xu C [1]

Author by ORCID

  • Van Der Heden Van Noort Gj [6]
  • Vu DT [6]
  • Prabu JR [6]
  • Perez Berrocal Da [6]
  • Horn-ghetko D [6]
  • Aguirre JD [4]
  • Regalado BD [3]
  • Li H [3]
  • Cutler JA [3]
  • Zhan W [3]
  • Sandate CR [3]
  • Ebert BL [3]
  • Thoma NH [3]
  • Li YD [3]
  • Mark KG [1]
  • Schleiffer A [1]
  • Hodakova Z [1]
  • Haselbach D [1]
  • Brown NG [1]
  • Bolhuis DL [1]
  • Grishkovskaya I [1]
  • Kotisch H [1]

Journal

  • NAT CHEM BIOL [6]
  • MOL CELL [3]
  • STRUCTURE [3]
  • CELL [1]
  • EMBO J [1]

Software

  • CRYOSPARC [4]
  • CTFFIND [3]

Microscope

  • FEI TITAN KRIOS [9]
  • TFS GLACIOS [2]
  • FEI TALOS ARCTICA [1]
  • FEI TECNAI SPIRIT [1]
  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [14]

Film or detector model

  • FEI FALCON IV 4K X 4K [4]
  • GATAN K3 6K X 4K [3]
  • GATAN K3 BIOQUANTUM 6K X 4K [3]
  • GATAN K2 SUMMIT 4K X 4K [2]
  • FEI EAGLE 4K X 4K [1]
  • FEI FALCON III 4K X 4K [1]

External links

  • PDBe-Kb [10]
  • UniProt [10]
  • Gene Ontology [8]
  • InterPro [8]
  • PDB [8]
  • Pfam [8]
  • Complex Portal [7]
  • ChEBI [6]
  • ChEMBL [6]
  • DrugBank [6]
  • EMPIAR [4]
  • AlphaFold DB [3]
Sort by: Download
Showing 1 - 10 of 14. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download
EMD-16355
Download Map
3D View
Structure of Dimeric HECT E3 Ubiquitin Ligase UBR5
Release date: Aug. 23, 2023
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8c06
Q-score: 0.478

Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA

Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]

EMD-16356
Download Map
3D View
Structure of HECT E3 UBR5 forming K48 linked Ubiquitin chains
Release date: Aug. 23, 2023
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8c07
Q-score: 0.416

Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA

Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]

EMD-16865
Download Map
3D View
Tetrameric HECT E3 Ubiquitin Ligase UBR5
Release date: Aug. 23, 2023
Resolution: 3.7 Å
EM Method: Single-particle

Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA

Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]

EMD-16866
Download Map
3D View
Cryo-EM map of ubiquitin-VME bound HECT E3 ligase UBR5
Release date: Aug. 23, 2023
Resolution: 5.3 Å
EM Method: Single-particle

Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA

Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]

EMD-16867
Download Map
3D View
Ubiquitin transfer from E2 to E3: UBE2D2-ubiquitin linked to HECT E3 ligase UBR5
Release date: Aug. 23, 2023
Resolution: 7.3 Å
EM Method: Single-particle

Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA

Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]

EMD-17466
Download Map
3D View
Cryo-EM map of HECT E3 ligase UBR5 forming K48 linked ubiquitin chains
Release date: Aug. 23, 2023
Resolution: 8.3 Å
EM Method: Single-particle

Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA

Nat Chem Biol (2024) 20 pp. 190-200 [ DOI: doi:10.1038/s41589-023-01414-2 Pubmed: 37620400 ]

EMD-16087
Download Map
3D View
Raw data
EMPIAR-11501
Structure of the human UBR5 Dimer.
Release date: July 12, 2023
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8bja
Q-score: 0.363

Hodakova Z, Grishkovskaya I, Brunner HL, Bolhuis DL, Belacic K, Schleiffer A, Kotisch H, Brown NG, Haselbach D

EMBO J (2023) 42 pp. e113348-e113348 [ DOI: doi:10.15252/embj.2022113348 Pubmed: 37409633 ]

EMD-17539
Download Map
3D View
Cryo-EM structure of dimeric UBR5
Release date: June 14, 2023
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8p82
Q-score: 0.299

Tsai JM, Aguirre JD, Li YD, Brown J, Focht V, Kater L, Kempf G, Sandoval B, Schmitt S, Rutter JC, Galli P, Sandate CR, Cutler JA, Zou C, Donovan KA, Lumpkin RJ, Cavadini S, Park PMC, Sievers Q, Hatton C, Ener E, Regalado BD, Sperling MT, Slabicki M, Kim J, Zon R, Zhang Z, Miller PG, Belizaire R, Sperling AS, Fischer ES, Irizarry R, Armstrong SA, Thoma NH, Ebert BL

Mol Cell (2023) 83 pp. 2753-2767.e10 [ Pubmed: 37478846 DOI: doi:10.1016/j.molcel.2023.06.028 ]

EMD-17540
Download Map
3D View
Cryo-EM structure of full-length human UBR5 homotetramer
Release date: June 14, 2023
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8p83
Q-score: 0.2

Tsai JM, Aguirre JD, Li YD, Brown J, Focht V, Kater L, Kempf G, Sandoval B, Schmitt S, Rutter JC, Galli P, Sandate CR, Cutler JA, Zou C, Donovan KA, Lumpkin RJ, Cavadini S, Park PMC, Sievers Q, Hatton C, Ener E, Regalado BD, Sperling MT, Slabicki M, Kim J, Zon R, Zhang Z, Miller PG, Belizaire R, Sperling AS, Fischer ES, Irizarry R, Armstrong SA, Thoma NH, Ebert BL

Mol Cell (2023) 83 pp. 2753- [ Pubmed: 37478846 DOI: doi:10.1016/j.molcel.2023.06.028 ]

EMD-17541
Download Map
3D View
Cryo-EM density map of UBR5 in complex with MCRS1
Release date: June 7, 2023
Resolution: 4.45 Å
EM Method: Single-particle

Mark KG, Kolla S, Aguirre JD, Garshott DM, Schmitt S, Haakonsen DL, Xu C, Kater L, Kempf G, Martinez-Gonzalez B, Akopian D, See SK, Thoma NH, Rape M

Cell (2023) 186 pp. 3460-3475.e23 [ Pubmed: 37478862 DOI: doi:10.1016/j.cell.2023.06.015 ]

Sort by: Download
Showing 1 - 10 of 14. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [14]

Current status

  • REL [14]

Sample type

  • Complex [13]
  • Protein [10]
  • Ligand [7]
  • Cellular component [1]

Organism

  • Homo sapiens [14]

EM Method

  • Single-particle [14]

Resolution

  • ≥ 2Å and < 3Å [3]
  • ≥ 3Å and < 4Å [6]
  • ≥ 4Å and < 5Å [1]
  • ≥ 5Å and < 6Å [1]
  • ≥ 6Å and < 8Å [1]
  • ≥ 8Å and < 12Å [1]
  • ≥ 20Å and < 30Å [1]

Model molecular weight

  • 500-1000 kDa [5]
  • 1-2 MDa [3]

Release Date

  • 2023 [14]

Author by name

  • Hehl LA [6]
  • Horn-ghetko D [6]
  • Mulder MPC [6]
  • Perez Berrocal Da [6]
  • Prabu JR [6]
  • Schulman BA [6]
  • Vollrath R [6]
  • Vu DT [6]
  • Van Der Heden Van Noort Gj [6]
  • Aguirre JD [4]
  • Kater L [4]
  • Kempf G [4]
  • Schmitt S [4]
  • Thoma NH [4]
  • Armstrong SA [3]
  • Belizaire R [3]
  • Brown J [3]
  • Cavadini S [3]
  • Cutler JA [3]
  • Donovan KA [3]
  • Ebert BL [3]
  • Ener E [3]
  • Finkin-groner E [3]
  • Fischer ES [3]
  • Focht V [3]
  • Galli P [3]
  • Hatton C [3]
  • He Q [3]
  • Irizarry R [3]
  • Kim J [3]
  • Li H [3]
  • Li YD [3]
  • Lin G [3]
  • Lumpkin RJ [3]
  • Ma X [3]
  • Miller PG [3]
  • Park PMC [3]
  • Regalado BD [3]
  • Rutter JC [3]
  • Sandate CR [3]
  • Sandoval B [3]
  • Sievers Q [3]
  • Slabicki M [3]
  • Sperling AS [3]
  • Sperling MT [3]
  • Tsai JM [3]
  • Wang F [3]
  • Yu Z [3]
  • Zhan W [3]
  • Zhang Z [3]
  • Zon R [3]
  • Zou C [3]
  • Akopian D [1]
  • Belacic K [1]
  • Bolhuis DL [1]
  • Brown NG [1]
  • Brunner HL [1]
  • Garshott DM [1]
  • Grishkovskaya I [1]
  • Haakonsen DL [1]
  • Haselbach D [1]
  • Hodakova Z [1]
  • Kolla S [1]
  • Kotisch H [1]
  • Mark KG [1]
  • Martinez-gonzalez B [1]
  • Rape M [1]
  • Schleiffer A [1]
  • See SK [1]
  • Xu C [1]

Author by ORCID

  • Van Der Heden Van Noort Gj [6]
  • Vu DT [6]
  • Prabu JR [6]
  • Perez Berrocal Da [6]
  • Horn-ghetko D [6]
  • Aguirre JD [4]
  • Regalado BD [3]
  • Li H [3]
  • Cutler JA [3]
  • Zhan W [3]
  • Sandate CR [3]
  • Ebert BL [3]
  • Thoma NH [3]
  • Li YD [3]
  • Mark KG [1]
  • Schleiffer A [1]
  • Hodakova Z [1]
  • Haselbach D [1]
  • Brown NG [1]
  • Bolhuis DL [1]
  • Grishkovskaya I [1]
  • Kotisch H [1]

Journal

  • NAT CHEM BIOL [6]
  • MOL CELL [3]
  • STRUCTURE [3]
  • CELL [1]
  • EMBO J [1]

Software

  • CRYOSPARC [4]
  • CTFFIND [3]

Microscope

  • FEI TITAN KRIOS [9]
  • TFS GLACIOS [2]
  • FEI TALOS ARCTICA [1]
  • FEI TECNAI SPIRIT [1]
  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [14]

Film or detector model

  • FEI FALCON IV 4K X 4K [4]
  • GATAN K3 6K X 4K [3]
  • GATAN K3 BIOQUANTUM 6K X 4K [3]
  • GATAN K2 SUMMIT 4K X 4K [2]
  • FEI EAGLE 4K X 4K [1]
  • FEI FALCON III 4K X 4K [1]

External links

  • PDBe-Kb [10]
  • UniProt [10]
  • Gene Ontology [8]
  • InterPro [8]
  • PDB [8]
  • Pfam [8]
  • Complex Portal [7]
  • ChEBI [6]
  • ChEMBL [6]
  • DrugBank [6]
  • EMPIAR [4]
  • AlphaFold DB [3]