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sample_name:"Human serotonin transporter in complex with Fab/Fv bound to ibogaine"

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EMD-8942
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Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine
Release date: April 24, 2019
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6dzy
Q-score: 0.256

Coleman JA, Yang D, Zhao Z, Wen PC, Yoshioka C, Tajkhorshid E, Gouaux E

Nature (2019) 569 pp. 141-145 [ Pubmed: 31019304 DOI: doi:10.1038/s41586-019-1135-1 ]

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Filter By

Current Database

  • EMDB [1]

Current status

  • REL [1]

Sample type

  • Complex [1]
  • Ligand [1]
  • Protein [1]

Organism

  • Mus musculus [1]
  • Homo sapiens [1]

EM Method

  • Single-particle [1]

Resolution

  • ≥ 4Å and < 5Å [1]

Model molecular weight

  • 100-250 kDa [1]

Release Date

  • 2019 [1]

Author by name

  • Coleman JA [1]
  • Gouaux E [1]
  • Tajkhorshid E [1]
  • Wen PC [1]
  • Yang D [1]
  • Yoshioka C [1]
  • Zhao Z [1]

Author by ORCID

  • Zhao Z [1]
  • Wen PC [1]
  • Coleman JA [1]

Journal

  • NATURE [1]

Microscope

  • FEI TITAN KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [1]

Film or detector model

  • GATAN K2 SUMMIT 4K X 4K [1]

External links

  • AlphaFold DB [1]
  • ChEBI [1]
  • ChEMBL [1]
  • InterPro [1]
  • PDB [1]
  • PDBe-Kb [1]
  • Pfam [1]
  • UniProt [1]