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sample_name:"HCN1"

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Current Database

  • EMDB [11]

Current status

  • REL [11]

Sample type

  • Protein [11]
  • Ligand [10]
  • Complex [9]
  • Cellular component [2]

Organism

  • Homo sapiens [11]

EM Method

  • Single-particle [11]

Resolution

  • ≥ 2Å and < 3Å [2]
  • ≥ 3Å and < 4Å [9]

Model molecular weight

  • 250-500 kDa [11]

Release Date

  • 2024 [7]
  • 2019 [2]
  • 2017 [2]

Author by name

  • Accardi A [4]
  • Cunningham KP [4]
  • Di Zanni E [4]
  • Goldstein PA [4]
  • Kim ED [4]
  • Larsson HP [4]
  • Lee C-H [4]
  • Lee CH [4]
  • Lee S [4]
  • Mackinnon R [4]
  • Nimigean CM [4]
  • Perez ME [4]
  • Tibbs GR [4]
  • Wu X [4]
  • Bickel K [3]
  • Burtscher V [3]
  • Chanda B [3]
  • Chang Y [3]
  • Chen J [3]
  • Cowgill J [3]
  • Huang J [3]
  • Mount J [3]
  • Yuan P [3]

Author by ORCID

  • Lee S [4]
  • Cunningham KP [4]
  • Larsson HP [4]
  • Goldstein PA [4]
  • Kim ED [4]
  • Nimigean CM [4]
  • Accardi A [4]
  • Tibbs GR [4]
  • Wu X [4]
  • Di Zanni E [4]
  • Perez ME [4]
  • Mount J [3]
  • Bickel K [3]
  • Chen J [3]
  • Yuan P [3]
  • Cowgill J [3]
  • Chanda B [3]

Journal

  • CELL [4]
  • NATURE [4]
  • NAT COMMUN [3]

Software

  • CRYOSPARC [3]
  • RELION [1]

Microscope

  • FEI TITAN KRIOS [9]
  • FEI TALOS ARCTICA [1]
  • TFS GLACIOS [1]

Electron Source

  • FIELD EMISSION GUN [11]

Film or detector model

  • GATAN K2 SUMMIT 4K X 4K [4]
  • GATAN K3 6K X 4K [4]
  • FEI FALCON IV 4K X 4K [3]

External links

  • AlphaFold DB [11]
  • Gene Ontology [11]
  • InterPro [11]
  • PDB [11]
  • PDBe-Kb [11]
  • Pfam [11]
  • UniProt [11]
  • ChEBI [10]
  • DrugBank [10]
  • ChEMBL [9]
  • Complex Portal [9]
  • EMPIAR [1]
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Showing 1 - 10 of 11. Page 1 of 2
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EMD-42116
Download Map
3D View
HCN1 complex with propofol
Release date: July 31, 2024
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8uc7
Q-score: 0.553

Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM

Nature (2024) 632 pp. 451-459 [ Pubmed: 39085604 DOI: doi:10.1038/s41586-024-07743-z ]

EMD-42117
Download Map
3D View
HCN1 nanodisc
Release date: July 31, 2024
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8uc8
Q-score: 0.539

Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM

Nature (2024) 632 pp. 451-459 [ Pubmed: 39085604 DOI: doi:10.1038/s41586-024-07743-z ]

EMD-44425
Download Map
3D View
HCN1 M305L with propofol
Release date: July 31, 2024
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9bc6
Q-score: 0.625

Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM

Nature (2024) 632 pp. 451-459 [ Pubmed: 39085604 DOI: doi:10.1038/s41586-024-07743-z ]

EMD-44426
Download Map
3D View
HCN1 M305L holo
Release date: July 31, 2024
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9bc7
Q-score: 0.496

Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM

Nature (2024) 632 pp. 451-459 [ Pubmed: 39085604 DOI: doi:10.1038/s41586-024-07743-z ]

EMD-41041
Download Map
3D View
Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG SPL
Release date: July 3, 2024
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8t50
Q-score: 0.385

Burtscher V, Mount J, Huang J, Cowgill J, Chang Y, Bickel K, Chen J, Yuan P, Chanda B

Nat Commun (2024) 15 pp. 5216-5216 [ DOI: doi:10.1038/s41467-024-49599-x Pubmed: 38890331 ]

EMD-41040
Download Map
3D View
Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG SPL
Release date: June 19, 2024
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8t4y
Q-score: 0.377

Burtscher V, Mount J, Huang J, Cowgill J, Chang Y, Bickel K, Chen J, Yuan P, Chanda B

Nat Commun (2024) 15 pp. 5216-5216 [ DOI: doi:10.1038/s41467-024-49599-x Pubmed: 38890331 ]

EMD-41036
Download Map
3D View
Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG SPL
Release date: June 12, 2024
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 8t4m
Q-score: 0.502

Burtscher V, Mount J, Huang J, Cowgill J, Chang Y, Bickel K, Chen J, Yuan P, Chanda B

Nat Commun (2024) 15 pp. 5216-5216 [ DOI: doi:10.1038/s41467-024-49599-x Pubmed: 38890331 ]

EMD-20846
Download Map
3D View
Human HCN1 channel in a hyperpolarized conformation
Release date: Dec. 11, 2019
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 6uqf
Q-score: 0.501

Lee CH, MacKinnon R

Cell (2019) 179 pp. 1582- [ Pubmed: 31787376 DOI: doi:10.1016/j.cell.2019.11.006 ]

EMD-20847
Download Map
3D View
Human HCN1 channel Y289D mutant
Release date: Dec. 11, 2019
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6uqg
Q-score: 0.449

Lee CH, MacKinnon R

Cell (2019) 179 pp. 1582- [ Pubmed: 31787376 DOI: doi:10.1016/j.cell.2019.11.006 ]

EMD-8511
Download Map
3D View
Raw data
EMPIAR-10081
Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel
Release date: Jan. 25, 2017
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 5u6o
Q-score: 0.45

Lee CH, MacKinnon R

Cell (2017) 168 pp. 111-120.e11 [ DOI: doi:10.1016/j.cell.2016.12.023 Pubmed: 28086084 ]

Sort by: Download
Showing 1 - 10 of 11. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [11]

Current status

  • REL [11]

Sample type

  • Protein [11]
  • Ligand [10]
  • Complex [9]
  • Cellular component [2]

Organism

  • Homo sapiens [11]

EM Method

  • Single-particle [11]

Resolution

  • ≥ 2Å and < 3Å [2]
  • ≥ 3Å and < 4Å [9]

Model molecular weight

  • 250-500 kDa [11]

Release Date

  • 2024 [7]
  • 2019 [2]
  • 2017 [2]

Author by name

  • Accardi A [4]
  • Cunningham KP [4]
  • Di Zanni E [4]
  • Goldstein PA [4]
  • Kim ED [4]
  • Larsson HP [4]
  • Lee C-H [4]
  • Lee CH [4]
  • Lee S [4]
  • Mackinnon R [4]
  • Nimigean CM [4]
  • Perez ME [4]
  • Tibbs GR [4]
  • Wu X [4]
  • Bickel K [3]
  • Burtscher V [3]
  • Chanda B [3]
  • Chang Y [3]
  • Chen J [3]
  • Cowgill J [3]
  • Huang J [3]
  • Mount J [3]
  • Yuan P [3]

Author by ORCID

  • Lee S [4]
  • Cunningham KP [4]
  • Larsson HP [4]
  • Goldstein PA [4]
  • Kim ED [4]
  • Nimigean CM [4]
  • Accardi A [4]
  • Tibbs GR [4]
  • Wu X [4]
  • Di Zanni E [4]
  • Perez ME [4]
  • Mount J [3]
  • Bickel K [3]
  • Chen J [3]
  • Yuan P [3]
  • Cowgill J [3]
  • Chanda B [3]

Journal

  • CELL [4]
  • NATURE [4]
  • NAT COMMUN [3]

Software

  • CRYOSPARC [3]
  • RELION [1]

Microscope

  • FEI TITAN KRIOS [9]
  • FEI TALOS ARCTICA [1]
  • TFS GLACIOS [1]

Electron Source

  • FIELD EMISSION GUN [11]

Film or detector model

  • GATAN K2 SUMMIT 4K X 4K [4]
  • GATAN K3 6K X 4K [4]
  • FEI FALCON IV 4K X 4K [3]

External links

  • AlphaFold DB [11]
  • Gene Ontology [11]
  • InterPro [11]
  • PDB [11]
  • PDBe-Kb [11]
  • Pfam [11]
  • UniProt [11]
  • ChEBI [10]
  • DrugBank [10]
  • ChEMBL [9]
  • Complex Portal [9]
  • EMPIAR [1]