Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

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Current Database

  • EMDB [11]

Current status

  • REL [11]

Sample type

  • Complex [11]
  • Protein [9]
  • Ligand [8]
  • DNA [6]

Organism

  • Saccharomyces cerevisiae [5]
  • Saccharomyces cerevisiae [3]
  • Xenopus laevis [3]
  • Dna molecule [2]
  • Thermotoga maritima [1]

EM Method

  • Single-particle [11]

Resolution

  • ≥ 2Å and < 3Å [1]
  • ≥ 3Å and < 4Å [8]
  • ≥ 8Å and < 12Å [1]
  • ≥ 20Å and < 30Å [1]

Model molecular weight

  • 500-1000 kDa [2]
  • 1-2 MDa [5]
  • 2-5 MDa [1]

Release Date

  • 2025 [2]
  • 2023 [3]
  • 2022 [5]
  • 2019 [1]

Author by name

  • Costa A [11]
  • Diffley JFX [7]
  • Greiwe JF [5]
  • Nans A [5]
  • Miller TCR [4]
  • Butryn A [3]
  • Chauhan AS [3]
  • Cvetkovic MA [3]
  • Fernandez-cuesta C [3]
  • Gambus A [3]
  • George R [3]
  • Gross MH [3]
  • Henrikus SS [3]
  • Jhujh SS [3]
  • Kingsley G [3]
  • Lewis JS [3]
  • Passaretti P [3]
  • Poovathumkadavil D [3]
  • Reynolds-winczura A [3]
  • Skagia A [3]
  • Sousa J [3]
  • Sousa JS [3]
  • Stewart GS [3]
  • Dekker NH [2]
  • Early A [2]
  • East P [2]
  • Howell S [2]
  • Lim CT [2]
  • Locke J [2]
  • Martino F [2]
  • Sanchez H [2]
  • Schreiber A [2]
  • Talele S [2]
  • Tan KW [2]
  • Bujnicki JM [1]
  • Dobrychlop M [1]
  • Gaur V [1]
  • Jaciuk M [1]
  • Kasprzak JM [1]
  • Nirwal S [1]
  • Nowotny M [1]
  • Renault L [1]
  • Swuec P [1]

Author by ORCID

  • Diffley JFX [7]
  • Costa A [7]
  • Nans A [5]
  • Greiwe JF [5]
  • Miller TCR [4]
  • Gross MH [3]
  • Jhujh SS [3]
  • Stewart GS [3]
  • Gambus A [3]
  • Henrikus SS [3]
  • Lewis JS [3]
  • Passaretti P [3]
  • Tan KW [2]
  • East P [2]
  • Schreiber A [2]
  • Early A [2]
  • Locke J [2]
  • Lim CT [2]
  • Dekker NH [2]
  • Renault L [1]
  • Nowotny M [1]
  • Swuec P [1]
  • Nirwal S [1]
  • Gaur V [1]
  • Jaciuk M [1]

Journal

  • NAT STRUCT MOL BIOL [4]
  • MOL CELL [3]
  • NATURE [3]
  • DNA REPAIR (AMST) [1]

Software

  • RELION [8]
  • CRYOSPARC [3]
  • CTFFIND [1]
  • GCTF [1]
  • PHENIX [1]

Microscope

  • FEI TITAN KRIOS [10]
  • JEOL 2100 [1]

Electron Source

  • FIELD EMISSION GUN [10]
  • LAB6 [1]

Film or detector model

  • GATAN K2 SUMMIT 4K X 4K [7]
  • FEI FALCON IV 4K X 4K [3]
  • GATAN ULTRASCAN 4000 4K X 4K [1]

External links

  • AlphaFold DB [9]
  • PDBe-Kb [9]
  • UniProt [9]
  • ChEBI [8]
  • ChEMBL [8]
  • DrugBank [8]
  • Gene Ontology [8]
  • InterPro [8]
  • PDB [8]
  • Pfam [8]
  • Complex Portal [4]
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Showing 1 - 10 of 11. Page 1 of 2
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EMD-19186
Download Map
3D View
Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
Release date: Jan. 1, 2025
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8rif
Q-score: 0.516

Lim CT, Miller TCR, Tan KW, Talele S, Early A, East P, Sanchez H, Dekker NH, Costa A, Diffley JFX

Nat Struct Mol Biol (2025) 32 pp. 1697-1707 [ Pubmed: 40588661 DOI: doi:10.1038/s41594-025-01591-9 ]

EMD-19187
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3D View
Cryo-EM structure of an MCM helicase single hexamer loaded onto dsDNA.
Release date: Jan. 1, 2025
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8rig
Q-score: 0.44

Lim CT, Miller TCR, Tan KW, Talele S, Early A, East P, Sanchez H, Dekker NH, Costa A, Diffley JFX

Nat Struct Mol Biol (2025) 32 pp. 1697-1707 [ Pubmed: 40588661 DOI: doi:10.1038/s41594-025-01591-9 ]

EMD-18191
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3D View
X. laevis CMG dimer bound to dimeric DONSON - without ATPase
Release date: Oct. 18, 2023
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8q6o
Q-score: 0.471

Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A

Mol Cell (2023) 83 pp. 4017- [ DOI: doi:10.1016/j.molcel.2023.09.029 Pubmed: 37820732 ]

EMD-18192
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3D View
X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase
Release date: Oct. 18, 2023
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8q6p
Q-score: 0.369

Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A

Mol Cell (2023) 83 pp. 4017- [ DOI: doi:10.1016/j.molcel.2023.09.029 Pubmed: 37820732 ]

EMD-18195
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3D View
Single CMG purified from replicating Xenopus egg extracts
Release date: Oct. 18, 2023
Resolution: 3.03 Å
EM Method: Single-particle

Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A

Mol Cell (2023) 83 pp. 4017-4031.e9 [ DOI: doi:10.1016/j.molcel.2023.09.029 Pubmed: 37820732 ]

EMD-13978
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3D View
S. cerevisiae CMGE nucleating origin DNA melting
Release date: June 15, 2022
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7qhs
Q-score: 0.473

Lewis JS, Gross MH, Sousa J, Henrikus SS, Greiwe JF, Nans A, Diffley JFX, Costa A

Nature (2022) 606 pp. 1007-1014 [ DOI: doi:10.1038/s41586-022-04829-4 Pubmed: 35705812 ]

EMD-13988
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3D View
S. cerevisiae CMGE dimer nucleating origin DNA melting
Release date: June 15, 2022
Resolution: 8.2 Å
EM Method: Single-particle

Lewis JS, Gross MH, Sousa J, Henrikus SS, Greiwe JF, Nans A, Diffley JFX, Costa A

Nature (2022) 606 pp. 1007-1014 [ DOI: doi:10.1038/s41586-022-04829-4 Pubmed: 35705812 ]

EMD-14439
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3D View
S. cerevisiae CMGE dimer nucleating origin DNA melting
Release date: June 15, 2022
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7z13
Q-score: 0.471

Lewis JS, Gross MH, Sousa J, Henrikus SS, Greiwe JF, Nans A, Diffley JFX, Costa A

Nature (2022) 606 pp. 1007-1014 [ DOI: doi:10.1038/s41586-022-04829-4 Pubmed: 35705812 ]

EMD-13176
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3D View
3.0 A resolution structure of a DNA-loaded MCM double hexamer
Release date: Feb. 2, 2022
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7p30
Q-score: 0.538

Greiwe JF, Miller TCR, Locke J, Martino F, Howell S, Schreiber A, Nans A, Diffley JFX, Costa A

Nat Struct Mol Biol (2022) 29 pp. 10-20 [ Pubmed: 34963704 DOI: doi:10.1038/s41594-021-00698-z ]

EMD-13211
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3D View
Structure of a DNA-loaded MCM double hexamer engaged with the Dbf4-dependent kinase
Release date: Feb. 2, 2022
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7p5z
Q-score: 0.451

Greiwe JF, Miller TCR, Locke J, Martino F, Howell S, Schreiber A, Nans A, Diffley JFX, Costa A

Nat Struct Mol Biol (2022) 29 pp. 10-20 [ Pubmed: 34963704 DOI: doi:10.1038/s41594-021-00698-z ]

Sort by: Download
Showing 1 - 10 of 11. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [11]

Current status

  • REL [11]

Sample type

  • Complex [11]
  • Protein [9]
  • Ligand [8]
  • DNA [6]

Organism

  • Saccharomyces cerevisiae [5]
  • Saccharomyces cerevisiae [3]
  • Xenopus laevis [3]
  • Dna molecule [2]
  • Thermotoga maritima [1]

EM Method

  • Single-particle [11]

Resolution

  • ≥ 2Å and < 3Å [1]
  • ≥ 3Å and < 4Å [8]
  • ≥ 8Å and < 12Å [1]
  • ≥ 20Å and < 30Å [1]

Model molecular weight

  • 500-1000 kDa [2]
  • 1-2 MDa [5]
  • 2-5 MDa [1]

Release Date

  • 2025 [2]
  • 2023 [3]
  • 2022 [5]
  • 2019 [1]

Author by name

  • Costa A [11]
  • Diffley JFX [7]
  • Greiwe JF [5]
  • Nans A [5]
  • Miller TCR [4]
  • Butryn A [3]
  • Chauhan AS [3]
  • Cvetkovic MA [3]
  • Fernandez-cuesta C [3]
  • Gambus A [3]
  • George R [3]
  • Gross MH [3]
  • Henrikus SS [3]
  • Jhujh SS [3]
  • Kingsley G [3]
  • Lewis JS [3]
  • Passaretti P [3]
  • Poovathumkadavil D [3]
  • Reynolds-winczura A [3]
  • Skagia A [3]
  • Sousa J [3]
  • Sousa JS [3]
  • Stewart GS [3]
  • Dekker NH [2]
  • Early A [2]
  • East P [2]
  • Howell S [2]
  • Lim CT [2]
  • Locke J [2]
  • Martino F [2]
  • Sanchez H [2]
  • Schreiber A [2]
  • Talele S [2]
  • Tan KW [2]
  • Bujnicki JM [1]
  • Dobrychlop M [1]
  • Gaur V [1]
  • Jaciuk M [1]
  • Kasprzak JM [1]
  • Nirwal S [1]
  • Nowotny M [1]
  • Renault L [1]
  • Swuec P [1]

Author by ORCID

  • Diffley JFX [7]
  • Costa A [7]
  • Nans A [5]
  • Greiwe JF [5]
  • Miller TCR [4]
  • Gross MH [3]
  • Jhujh SS [3]
  • Stewart GS [3]
  • Gambus A [3]
  • Henrikus SS [3]
  • Lewis JS [3]
  • Passaretti P [3]
  • Tan KW [2]
  • East P [2]
  • Schreiber A [2]
  • Early A [2]
  • Locke J [2]
  • Lim CT [2]
  • Dekker NH [2]
  • Renault L [1]
  • Nowotny M [1]
  • Swuec P [1]
  • Nirwal S [1]
  • Gaur V [1]
  • Jaciuk M [1]

Journal

  • NAT STRUCT MOL BIOL [4]
  • MOL CELL [3]
  • NATURE [3]
  • DNA REPAIR (AMST) [1]

Software

  • RELION [8]
  • CRYOSPARC [3]
  • CTFFIND [1]
  • GCTF [1]
  • PHENIX [1]

Microscope

  • FEI TITAN KRIOS [10]
  • JEOL 2100 [1]

Electron Source

  • FIELD EMISSION GUN [10]
  • LAB6 [1]

Film or detector model

  • GATAN K2 SUMMIT 4K X 4K [7]
  • FEI FALCON IV 4K X 4K [3]
  • GATAN ULTRASCAN 4000 4K X 4K [1]

External links

  • AlphaFold DB [9]
  • PDBe-Kb [9]
  • UniProt [9]
  • ChEBI [8]
  • ChEMBL [8]
  • DrugBank [8]
  • Gene Ontology [8]
  • InterPro [8]
  • PDB [8]
  • Pfam [8]
  • Complex Portal [4]