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grant_code:"2016-R-49"

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EMD-18442
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Structure of active state MC4R in complex with a potent ligand mimicking nanobody
CryoEM
Release date: Sept. 25, 2024
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8qj2
Q-score: 0.431
Similar entry percentile: 41%

Fontaine T, Busch A, Laeremans T, De Cesco S, Liang YL, Jaakola VP, Sands Z, Triest S, Masiulis S, Dekeyzer L, Samyn N, Loeys N, Perneel L, Debaere M, Martini M, Vantieghem C, Virmani R, Skieterska K, Staelens S, Barroco R, Van Roy M, Menet C

Nat Commun (2024) 15 pp. 7029-7029 [ Pubmed: 39353917 DOI: doi:10.1038/s41467-024-50827-7 ]

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Filter By

Current Database

  • EMDB [1]

Current status

  • REL [1]

Sample type

  • Complex [1]
  • Protein [1]

Organism

  • Discosoma sp. [1]
  • Homo sapiens [1]
  • Lama glama [1]

EM Method

  • Single-particle [1]

Resolution

  • ≥ 3Å and < 4Å [1]

Model molecular weight

  • 100-250 kDa [1]

Release Date

  • 2024 [1]

Author by name

  • Barroco R [1]
  • Busch A [1]
  • De Cesco S [1]
  • Debaere M [1]
  • Dekeyzer L [1]
  • Fontaine T [1]
  • Jaakola V-P [1]
  • Jaakola VP [1]
  • Laeremans T [1]
  • Liang YL [1]
  • Loeys N [1]
  • Martini M [1]
  • Masiulis S [1]
  • Menet C [1]
  • Perneel L [1]
  • Samyn N [1]
  • Sands Z [1]
  • Skieterska K [1]
  • Staelens S [1]
  • Triest S [1]
  • Van Roy M [1]
  • Vantieghem C [1]
  • Virmani R [1]

Author by ORCID

  • Jaakola VP [1]
  • Menet C [1]
  • De Cesco S [1]

Journal

  • NAT COMMUN [1]

Microscope

  • TFS GLACIOS [1]

Electron Source

  • FIELD EMISSION GUN [1]

Film or detector model

  • FEI FALCON IV 4K X 4K [1]

External links

  • AlphaFold DB [1]
  • Gene Ontology [1]
  • InterPro [1]
  • PDB [1]
  • PDBe-Kb [1]
  • Pfam [1]
  • UniProt [1]