EMD-18442

Single-particle
3.4 Å
EMD-18442
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Deposition: 12/09/2023
Map released: 25/09/2024
Last modified: 23/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-18442
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8qj2 summary report (pdf.gz) Map and 8qj2 FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of active state MC4R in complex with a potent ligand mimicking nanobody

EMD-18442

Single-particle
3.4 Å
EMD-18442
3D View Gallery
Deposition: 12/09/2023
Map released: 25/09/2024
Last modified: 23/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama, Discosoma sp.
Sample: MC4R receptor in complex with Gs protein heterotrimer, nanobody-35/ConfoBody 35 and ligand-mimicking nanobody
Fitted models: 8qj2

Deposition Authors: Busch A, Jaakola V-P, Masiulis S
Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist.
Fontaine T, Busch A, Laeremans T, De Cesco S , Liang YL, Jaakola VP , Sands Z, Triest S, Masiulis S, Dekeyzer L, Samyn N, Loeys N, Perneel L, Debaere M, Martini M, Vantieghem C, Virmani R, Skieterska K, Staelens S, Barroco R, Van Roy M, Menet C
(2024) Nat Commun , 15 , 7029 - 7029
PUBMED: 39353917
DOI: doi:10.1038/s41467-024-50827-7
ISSN: 2041-1723
Grant Support: