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EMD-18442
Structure of active state MC4R in complex with a potent ligand mimicking nanobody
EMD-18442
Single-particle3.4 Å
Deposition: 12/09/2023Map released: 25/09/2024
Last modified: 23/04/2025
Sample Organism:
Homo sapiens,
Lama glama,
Discosoma sp.
Sample: MC4R receptor in complex with Gs protein heterotrimer, nanobody-35/ConfoBody 35 and ligand-mimicking nanobody
Fitted models: 8qj2
Deposition Authors: Busch A, Jaakola V-P, Masiulis S
Sample: MC4R receptor in complex with Gs protein heterotrimer, nanobody-35/ConfoBody 35 and ligand-mimicking nanobody
Fitted models: 8qj2
Deposition Authors: Busch A, Jaakola V-P, Masiulis S
Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist.
Fontaine T,
Busch A,
Laeremans T,
De Cesco S 
,
Liang YL,
Jaakola VP ,
Sands Z,
Triest S,
Masiulis S,
Dekeyzer L,
Samyn N,
Loeys N,
Perneel L,
Debaere M,
Martini M,
Vantieghem C,
Virmani R,
Skieterska K,
Staelens S,
Barroco R,
Van Roy M,
Menet C
(2024) Nat Commun , 15 , 7029 - 7029
,
Liang YL,
Jaakola VP ,
Sands Z,
Triest S,
Masiulis S,
Dekeyzer L,
Samyn N,
Loeys N,
Perneel L,
Debaere M,
Martini M,
Vantieghem C,
Virmani R,
Skieterska K,
Staelens S,
Barroco R,
Van Roy M,
Menet C
(2024) Nat Commun , 15 , 7029 - 7029
Grant Support:
- Other government: 2016-R-49 (Belgium)
- Other government: HBC_2020.2042 (Belgium)