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EMD-47111
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cryo-EM structure of human Cereblon/DDB1 in complex with a non-traditional CRBN binder
CryoEM
Release date: Dec. 25, 2024
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9dqd
Q-score: 0.467
Similar entry percentile: 38%

Lejava A, Miseo GA, Phan T, Zhu J, Powers HL, Li J, Mortensen DS, Zapf CW, Khambatta G, Buenviaje J, Holmberg-Douglas N

Acs Med.Chem.Lett. (2025) 16 pp. 89-95 [ DOI: doi:10.1021/acsmedchemlett.4c00462 Pubmed: 39811117 ]

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Filter By

Current Database

  • EMDB [1]

Current status

  • REL [1]

Sample type

  • Complex [1]
  • Ligand [1]
  • Protein [1]

Organism

  • Homo sapiens [1]

EM Method

  • Single-particle [1]

Resolution

  • ≥ 3Å and < 4Å [1]

Model molecular weight

  • 100-250 kDa [1]

Release Date

  • 2024 [1]

Author by name

  • Buenviaje J [1]
  • Holmberg-douglas N [1]
  • Khambatta G [1]
  • Lejava A [1]
  • Li J [1]
  • Miseo GA [1]
  • Mortensen DS [1]
  • Pagarigan B [1]
  • Phan T [1]
  • Powers HL [1]
  • Zapf CW [1]
  • Zhu J [1]

Journal

  • ACS MED.CHEM.LETT. [1]

Software

  • CRYOSPARC [1]

Microscope

  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [1]

Film or detector model

  • FEI FALCON IV 4K X 4K [1]

External links

  • AlphaFold DB [1]
  • ChEBI [1]
  • ChEMBL [1]
  • Complex Portal [1]
  • DrugBank [1]
  • Gene Ontology [1]
  • InterPro [1]
  • PDB [1]
  • PDBe-Kb [1]
  • Pfam [1]
  • UniProt [1]