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EMD-47335
Cryo-EM focused map masking butyrolactol A binding site of the C. neoformans lipid flippase Apt1-Cdc50 bound with butyrolactol A in the E2P state
EMD-47335
Single-particle2.93 Å
Deposition: 17/10/2024Map released: 05/02/2025
Last modified: 05/02/2025
Sample Organism:
Cryptococcus neoformans var. grubii H99
Sample: Apt1-Cdc50 heterodimer bound with butyrolactol A
Deposition Authors: Duan HD
,
Li H
Sample: Apt1-Cdc50 heterodimer bound with butyrolactol A
Deposition Authors: Duan HD
,
Li H
Butyrolactol A is a phospholipid flippase inhibitor that potentiates the bioactivity of caspofungin against resistant fungi.
Chen X ,
Duan HD ,
Hoy MJ,
Koteva K,
Spitzer M,
Guitor AK,
Puumala E,
Hu G,
Yiu B,
Chou S,
Bian Z,
Guo ABY,
Sun S,
Robbins N,
Cook MA,
Truant R,
MacNeil LT,
Brown ED,
Kronstad JW,
Cowen LE,
Heitman J ,
Li H ,
Wright GD
(2025) bioRxiv
,
Duan HD ,
Hoy MJ,
Koteva K,
Spitzer M,
Guitor AK,
Puumala E,
Hu G,
Yiu B,
Chou S,
Bian Z,
Guo ABY,
Sun S,
Robbins N,
Cook MA,
Truant R,
MacNeil LT,
Brown ED,
Kronstad JW,
Cowen LE,
Heitman J ,
Li H ,
Wright GD
(2025) bioRxiv
Grant Support: