Fasnall (CHEBI:145520)

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ChEBI Name	Fasnall

ChEBI ID	CHEBI:145520

Definition	A racemate comprising equimolar amounts of (R)- and (S)-Fasnall. Both enantiomers act as fatty acid synthase inhibitors, although the (S)-enantiomer was found to be more than 4 times as active as the (R)-enantiomer.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Ceri

Supplier Information

Download	Molfile XML SDF

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Formula

C19H22N4S

Net Charge

Average Mass

338.470

Monoisotopic Mass

338.15652

InChI

InChI=1S/C19H22N4S/c1-13-14(2)24-19-17(13)18(20-12-21-19)22-16-8-9-23(11-16)10-15-6-4-3-5-7-15/h3-7,12,16H,8-11H2,1-2H3,(H,20,21,22)

InChIKey

VSXRMURGJRAOCU-UHFFFAOYSA-N

SMILES

C=12C(=C(N=CN1)NC3CN(CC3)CC=4C=CC=CC4)C(=C(S2)C)C

Roles Classification
Biological Role(s):	EC 2.3.1.85 (fatty acid synthase) inhibitor An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of fatty acid synthase (EC 2.3.1.85), a multi-enzyme protein involved in fatty acid synthesis. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. fatty acid synthesis inhibitor Any pathway inhibitor that inhibits the synthesis of fatty acids.

ChEBI Ontology
Outgoing	Fasnall (CHEBI:145520) has part (R)-Fasnall (CHEBI:145533) Fasnall (CHEBI:145520) has part (S)-Fasnall (CHEBI:145534) Fasnall (CHEBI:145520) has role anti-HIV agent (CHEBI:64946) Fasnall (CHEBI:145520) has role apoptosis inducer (CHEBI:68495) Fasnall (CHEBI:145520) has role EC 2.3.1.85 (fatty acid synthase) inhibitor (CHEBI:71476) Fasnall (CHEBI:145520) has role fatty acid synthesis inhibitor (CHEBI:50185) Fasnall (CHEBI:145520) is a racemate (CHEBI:60911)

IUPAC Name

rac-N-(1-benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine

Registry Number	Type	Source
929978-58-5	CAS Registry Number	ChEBI

Last Modified

27 November 2019