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CHEBI:28088 - genistein
| Formula | C15H10O5 |
| Net Charge | 0 |
| Average Mass | 270.240 |
| Monoisotopic Mass | 270.05282 |
| SMILES | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 |
| InChI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H |
| InChIKey | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Cordyceps sinensis (ncbitaxon:72228) | mycelium (BTO:0001436) | PubMed (21848266) | Ethanolic extract of dried mycelia |
| Homo sapiens (ncbitaxon:9606) | |||
| blood plasma (BTO:0000118) | PubMed (17449595) | ||
| urine (BTO:0001419) | PubMed (24023812) | ||
| Brassica napus (ncbitaxon:3708) | |||
| leaf lamina (BTO:0000719) | MetaboLights (MTBLS309) | From MetaboLights | |
| - | MetaboLights (MTBLS312) | From MetaboLights | |
| Arabidopsis thaliana (ncbitaxon:3702) | cell suspension culture (BTO:0000221) | MetaboLights (MTBLS311) | From MetaboLights |
| Vigna angularis (ncbitaxon:3914) | seed (BTO:0001226) | PubMed (25593647) |
| Roles Classification |
|---|
| Biological Roles: | EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. human urinary metabolite Any metabolite (endogenous or exogenous) found in human urine samples. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. tyrosine kinase inhibitor Any protein kinase inhibitor that interferes with the action of tyrosine kinase. phytoestrogen Any compound produced by a plant that happens to have estrogenic activity. |
| Applications: | geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| genistein (CHEBI:28088) has role antineoplastic agent (CHEBI:35610) |
| genistein (CHEBI:28088) has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750) |
| genistein (CHEBI:28088) has role geroprotector (CHEBI:176497) |
| genistein (CHEBI:28088) has role human urinary metabolite (CHEBI:84087) |
| genistein (CHEBI:28088) has role phytoestrogen (CHEBI:76989) |
| genistein (CHEBI:28088) has role plant metabolite (CHEBI:76924) |
| genistein (CHEBI:28088) has role tyrosine kinase inhibitor (CHEBI:38637) |
| genistein (CHEBI:28088) is a 7-hydroxyisoflavones (CHEBI:55465) |
| genistein (CHEBI:28088) is conjugate acid of genistein(1−) (CHEBI:74224) |
| Incoming Relation(s) |
| 2-hydroxy-2,3-dihydrogenistein (CHEBI:31080) has functional parent genistein (CHEBI:28088) |
| 2'-hydroxygenistein (CHEBI:70031) has functional parent genistein (CHEBI:28088) |
| 5,7,4'-trihydroxy-6,8-diprenylisoflavone (CHEBI:66263) has functional parent genistein (CHEBI:28088) |
| genistein 4',7-disulfate (CHEBI:55454) has functional parent genistein (CHEBI:28088) |
| genistein 7-O-β-D-glucoside (CHEBI:27514) has functional parent genistein (CHEBI:28088) |
| genistein 8-C-glucoside (CHEBI:5304) has functional parent genistein (CHEBI:28088) |
| genistein sulfate (CHEBI:233021) has functional parent genistein (CHEBI:28088) |
| genistin 7-O-gentiobioside (CHEBI:145776) has functional parent genistein (CHEBI:28088) |
| prunetin (CHEBI:8600) has functional parent genistein (CHEBI:28088) |
| talosin A (CHEBI:66186) has functional parent genistein (CHEBI:28088) |
| talosin B (CHEBI:66187) has functional parent genistein (CHEBI:28088) |
| genistein(1−) (CHEBI:74224) is conjugate base of genistein (CHEBI:28088) |
| IUPAC Name |
|---|
| 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one |
| Synonyms | Source |
|---|---|
| Genistein | KEGG COMPOUND |
| 5,7,4'-Trihydroxyisoflavone | KEGG COMPOUND |
| GENISTEIN | PDBeChem |
| 4',5,7-trihydroxyisoflavone | ChemIDplus |
| 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | ChEBI |
| 4',5,7-trihydroxyisoflavone | ChEBI |
| Brand Names | Source |
|---|---|
| Prunetol | DrugBank |
| Sophoricol | DrugBank |
| Registry Numbers | Sources |
|---|---|
| Reaxys:263823 | Reaxys |
| CAS:446-72-0 | KEGG COMPOUND |
| CAS:446-72-0 | ChemIDplus |
| Citations |
|---|