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CHEBI:28088 - genistein
| Formula | C15H10O5 |
| Net Charge | 0 |
| Average Mass | 270.240 |
| Monoisotopic Mass | 270.05282 |
| SMILES | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 |
| InChI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H |
| InChIKey | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Arabidopsis thaliana (ncbitaxon:3702) | cell suspension culture (BTO:0000221) | MetaboLights (MTBLS311) | From MetaboLights |
| Brassica napus (ncbitaxon:3708) | |||
| leaf lamina (BTO:0000719) | MetaboLights (MTBLS309) | From MetaboLights | |
| - | MetaboLights (MTBLS312) | From MetaboLights | |
| Cordyceps sinensis (ncbitaxon:72228) | mycelium (BTO:0001436) | PubMed (21848266) | Ethanolic extract of dried mycelia |
| Homo sapiens (ncbitaxon:9606) | |||
| blood plasma (BTO:0000118) | PubMed (17449595) | ||
| urine (BTO:0001419) | PubMed (24023812) | ||
| Vigna angularis (ncbitaxon:3914) | seed (BTO:0001226) | PubMed (25593647) |
| Roles Classification |
|---|
| Biological Roles: | tyrosine kinase inhibitor Any protein kinase inhibitor that interferes with the action of tyrosine kinase. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. phytoestrogen Any compound produced by a plant that happens to have estrogenic activity. anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. antiviral agent A substance that destroys or inhibits replication of viruses. human urinary metabolite Any metabolite (endogenous or exogenous) found in human urine samples. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. bone density conservation agent An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis. antifibrotic agent Any agent which acts to reduce fibrosis. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| genistein (CHEBI:28088) has role anticoronaviral agent (CHEBI:149553) |
| genistein (CHEBI:28088) has role antifibrotic agent (CHEBI:233423) |
| genistein (CHEBI:28088) has role antineoplastic agent (CHEBI:35610) |
| genistein (CHEBI:28088) has role antiviral agent (CHEBI:22587) |
| genistein (CHEBI:28088) has role bone density conservation agent (CHEBI:50646) |
| genistein (CHEBI:28088) has role cardiovascular drug (CHEBI:35554) |
| genistein (CHEBI:28088) has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750) |
| genistein (CHEBI:28088) has role geroprotector (CHEBI:176497) |
| genistein (CHEBI:28088) has role human urinary metabolite (CHEBI:84087) |
| genistein (CHEBI:28088) has role phytoestrogen (CHEBI:76989) |
| genistein (CHEBI:28088) has role plant metabolite (CHEBI:76924) |
| genistein (CHEBI:28088) has role tyrosine kinase inhibitor (CHEBI:38637) |
| genistein (CHEBI:28088) is a 7-hydroxyisoflavones (CHEBI:55465) |
| genistein (CHEBI:28088) is conjugate acid of genistein(1−) (CHEBI:74224) |
| Incoming Relation(s) |
| 2-hydroxy-2,3-dihydrogenistein (CHEBI:31080) has functional parent genistein (CHEBI:28088) |
| 2'-hydroxygenistein (CHEBI:70031) has functional parent genistein (CHEBI:28088) |
| 5,7,4'-trihydroxy-6,8-diprenylisoflavone (CHEBI:66263) has functional parent genistein (CHEBI:28088) |
| genistein 4',7-disulfate (CHEBI:55454) has functional parent genistein (CHEBI:28088) |
| genistein 7-O-β-D-glucoside (CHEBI:27514) has functional parent genistein (CHEBI:28088) |
| genistein 8-C-glucoside (CHEBI:5304) has functional parent genistein (CHEBI:28088) |
| genistein sulfate (CHEBI:233021) has functional parent genistein (CHEBI:28088) |
| genistin 7-O-gentiobioside (CHEBI:145776) has functional parent genistein (CHEBI:28088) |
| prunetin (CHEBI:8600) has functional parent genistein (CHEBI:28088) |
| talosin A (CHEBI:66186) has functional parent genistein (CHEBI:28088) |
| talosin B (CHEBI:66187) has functional parent genistein (CHEBI:28088) |
| genistein(1−) (CHEBI:74224) is conjugate base of genistein (CHEBI:28088) |
| IUPAC Name |
|---|
| 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one |
| INNs | Source |
|---|---|
| genisteina | WHO MedNet |
| genisteine | WHO MedNet |
| Synonyms | Source |
|---|---|
| 4',5,7-trihydroxyisoflavone | ChemIDplus |
| 4',5,7-trihydroxyisoflavone | ChEBI |
| 5,7,4'-Trihydroxyisoflavone | KEGG COMPOUND |
| 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | ChEBI |
| .alpha.-isospartein | ChEMBL |
| (-)-.alpha.-isosparteine | ChEMBL |
| Brand Names | Source |
|---|---|
| Bonistein | ChEMBL |
| Prunetol | DrugBank |
| Sophoricol | DrugBank |
| Registry Numbers | Sources |
|---|---|
| Reaxys:263823 | Reaxys |
| CAS:446-72-0 | ChemIDplus |
| CAS:446-72-0 | KEGG COMPOUND |
| Citations |
|---|