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CHEBI:28088 - genistein
| Formula | C15H10O5 |
| Net Charge | 0 |
| Average Mass | 270.240 |
| Monoisotopic Mass | 270.05282 |
| SMILES | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 |
| InChI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H |
| InChIKey | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Arabidopsis thaliana (ncbitaxon:3702) | cell suspension culture (BTO:0000221) | MetaboLights (MTBLS311) | From MetaboLights |
| Brassica napus (ncbitaxon:3708) | |||
| leaf lamina (BTO:0000719) | MetaboLights (MTBLS309) | From MetaboLights | |
| - | MetaboLights (MTBLS312) | From MetaboLights | |
| Cordyceps sinensis (ncbitaxon:72228) | mycelium (BTO:0001436) | PubMed (21848266) | Ethanolic extract of dried mycelia |
| Homo sapiens (ncbitaxon:9606) | |||
| blood plasma (BTO:0000118) | PubMed (17449595) | ||
| urine (BTO:0001419) | PubMed (24023812) | ||
| Vigna angularis (ncbitaxon:3914) | seed (BTO:0001226) | PubMed (25593647) |
| Roles Classification |
|---|
| Biological Roles: | human urinary metabolite Any metabolite (endogenous or exogenous) found in human urine samples. anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. tyrosine kinase inhibitor Any protein kinase inhibitor that interferes with the action of tyrosine kinase. EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. antiviral agent A substance that destroys or inhibits replication of viruses. phytoestrogen Any compound produced by a plant that happens to have estrogenic activity. |
| Applications: | cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antifibrotic agent Any agent which acts to reduce fibrosis. bone density conservation agent An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| genistein (CHEBI:28088) has role anticoronaviral agent (CHEBI:149553) |
| genistein (CHEBI:28088) has role antifibrotic agent (CHEBI:233423) |
| genistein (CHEBI:28088) has role antineoplastic agent (CHEBI:35610) |
| genistein (CHEBI:28088) has role antiviral agent (CHEBI:22587) |
| genistein (CHEBI:28088) has role bone density conservation agent (CHEBI:50646) |
| genistein (CHEBI:28088) has role cardiovascular drug (CHEBI:35554) |
| genistein (CHEBI:28088) has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750) |
| genistein (CHEBI:28088) has role geroprotector (CHEBI:176497) |
| genistein (CHEBI:28088) has role human urinary metabolite (CHEBI:84087) |
| genistein (CHEBI:28088) has role phytoestrogen (CHEBI:76989) |
| genistein (CHEBI:28088) has role plant metabolite (CHEBI:76924) |
| genistein (CHEBI:28088) has role tyrosine kinase inhibitor (CHEBI:38637) |
| genistein (CHEBI:28088) is a 7-hydroxyisoflavones (CHEBI:55465) |
| genistein (CHEBI:28088) is conjugate acid of genistein(1−) (CHEBI:74224) |
| Incoming Relation(s) |
| 2-hydroxy-2,3-dihydrogenistein (CHEBI:31080) has functional parent genistein (CHEBI:28088) |
| 2'-hydroxygenistein (CHEBI:70031) has functional parent genistein (CHEBI:28088) |
| 5,7,4'-trihydroxy-6,8-diprenylisoflavone (CHEBI:66263) has functional parent genistein (CHEBI:28088) |
| genistein 4',7-disulfate (CHEBI:55454) has functional parent genistein (CHEBI:28088) |
| genistein 7-O-β-D-glucoside (CHEBI:27514) has functional parent genistein (CHEBI:28088) |
| genistein 8-C-glucoside (CHEBI:5304) has functional parent genistein (CHEBI:28088) |
| genistein sulfate (CHEBI:233021) has functional parent genistein (CHEBI:28088) |
| genistin 7-O-gentiobioside (CHEBI:145776) has functional parent genistein (CHEBI:28088) |
| prunetin (CHEBI:8600) has functional parent genistein (CHEBI:28088) |
| talosin A (CHEBI:66186) has functional parent genistein (CHEBI:28088) |
| talosin B (CHEBI:66187) has functional parent genistein (CHEBI:28088) |
| genistein(1−) (CHEBI:74224) is conjugate base of genistein (CHEBI:28088) |
| IUPAC Name |
|---|
| 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one |
| INNs | Source |
|---|---|
| genisteina | WHO MedNet |
| genisteine | WHO MedNet |
| Synonyms | Source |
|---|---|
| 4',5,7-trihydroxyisoflavone | ChemIDplus |
| 4',5,7-trihydroxyisoflavone | ChEBI |
| 5,7,4'-Trihydroxyisoflavone | KEGG COMPOUND |
| 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | ChEBI |
| .alpha.-isospartein | ChEMBL |
| (-)-.alpha.-isosparteine | ChEMBL |
| Brand Names | Source |
|---|---|
| Bonistein | ChEMBL |
| Prunetol | DrugBank |
| Sophoricol | DrugBank |
| Registry Numbers | Sources |
|---|---|
| Reaxys:263823 | Reaxys |
| CAS:446-72-0 | ChemIDplus |
| CAS:446-72-0 | KEGG COMPOUND |
| Citations |
|---|