Mechanistic models describing neurodegenerative disease processes
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Model space in neurodegeneration - model landscape map. This cellular and molecular process diagram of neurodegeneration was created by integrating the mechanisms described in 89 neurodegenerative disease models published in the literature. It is an abstract representation of the processes involved, i.e. only important mechanisms of each process are shown for better visualisation. Boundaries of subcellular organelles are represented as solid lines, cell boundaries as thick solid lines and the blood-brain barrier as thick dotted lines. The 15 biological processes associated with ND that the models describe are in capital bold red font. The models falling under each of these processes are displayed as numbers and hyperlinked to the original publication or if the models exist in BioModels it is linked to model page in BioModels. Models involving more than one process are over-lined. The density of distribution of models in each process is illustrated as colour gradient (gradient definition is provided in the figure).
A review of mechanistic models on neurodegenerative disease processes was published in CPT:PSP.
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