BioModels is a repository of mathematical models of biological and biomedical systems.
It hosts a vast selection of existing literature-based physiologically and pharmaceutically
relevant mechanistic models in standard formats. Our mission is to provide the systems
modelling community with reproducible, high-quality,
models published in the scientific literature. More information about using BioModels such as model submission, update, publication can be found in the FAQ.
Zake2021 - PBPK model of metformin in mice and humans
It's a simplified PBPK model for metformin in humans and mice. Model is used to study the metformin concentration-time profile on different tissues by applying some parameters from mice and other human tissue data. Using this model, one can predict the dynamics of metformin distribution in humans based on the information of the physiological properties of humans, the physicochemical properties of metformin and its absorption/excretion.
Rahuman S Malik-Sheriff, Mihai Glont, Tung V N Nguyen, Krishna Tiwari,
Matthew G Roberts, Ashley Xavier, Manh T Vu, Jinghao Men, Matthieu Maire, Sarubini Kananathan,
Emma L Fairbanks, Johannes P Meyer,
Chinmay Arankalle, Thawfeek M Varusai, Vincent Knight-Schrijver, Lu Li, Corina Dueñas-Roca, Gaurhari Dass,
Sarah M Keating, Young M Park, Nicola Buso, Nicolas Rodriguez, Michael Hucka, and Henning Hermjakob
Mihai Glont, Tung V N Nguyen, Martin Graesslin, Robert Hälke, Raza Ali, Jochen Schramm,
Sarala M Wimalaratne, Varun B Kothamachu, Nicolas Rodriguez, Maciej J Swat, Jurgen Eils,
Roland Eils, Camille Laibe, Rahuman S Malik-Sheriff, Vijayalakshmi Chelliah, Nicolas Le Novère,
and Henning Hermjakob