BioModels is a repository of mathematical models of biological and biomedical systems.
It hosts a vast selection of existing literature-based physiologically and pharmaceutically
relevant mechanistic models in standard formats. Our mission is to provide the systems
modelling community with reproducible, high-quality,
models published in the scientific literature. More information about using BioModels such as model submission, update, publication can be found in the FAQ.
Ito2019 - Gefitinib resistance of lung adenocarcinoma caused by MET amplification
It's a mechanistic ODE model exploring the mechanism responsible for Gefitinib (Epidermal growth factor receptor-Tyrosine Kinase inhibitor (EGFR-TKI)) resistance in MET (MET proto-oncogene, receptor tyrosine kinase) amplified lung adenocarcinoma.
Publication: Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding., American journal of physiology. Endocrinology and metabolism (2018)
Rahuman S Malik-Sheriff, Mihai Glont, Tung V N Nguyen, Krishna Tiwari,
Matthew G Roberts, Ashley Xavier, Manh T Vu, Jinghao Men, Matthieu Maire, Sarubini Kananathan,
Emma L Fairbanks, Johannes P Meyer,
Chinmay Arankalle, Thawfeek M Varusai, Vincent Knight-Schrijver, Lu Li, Corina Dueñas-Roca, Gaurhari Dass,
Sarah M Keating, Young M Park, Nicola Buso, Nicolas Rodriguez, Michael Hucka, and Henning Hermjakob
Mihai Glont, Tung V N Nguyen, Martin Graesslin, Robert Hälke, Raza Ali, Jochen Schramm,
Sarala M Wimalaratne, Varun B Kothamachu, Nicolas Rodriguez, Maciej J Swat, Jurgen Eils,
Roland Eils, Camille Laibe, Rahuman S Malik-Sheriff, Vijayalakshmi Chelliah, Nicolas Le Novère,
and Henning Hermjakob