BioModels is a repository of mathematical models of biological and biomedical systems. It hosts a vast selection of existing literature-based physiologically and pharmaceutically relevant mechanistic models in standard formats. Our mission is to provide the systems modelling community with reproducible, high-quality, freely-accessible models published in the scientific literature. More information about using BioModels such as model submission, update, publication can be found in the FAQ.

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1,040 models


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833 models

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1,132 classes
1,040 models
1,305 models
833 models
1,132 classes

Model of The Month

December,  2021

Zake2021 - PBPK model of metformin in mice and humans

It's a simplified PBPK model for metformin in humans and mice. Model is used to study the metformin concentration-time profile on different tissues by applying some parameters from mice and other human tissue data. Using this model, one can predict the dynamics of metformin distribution in humans based on the information of the physiological properties of humans, the physicochemical properties of metformin and its absorption/excretion.

Model(s) associated with this Model of the Month: BIOMD0000001028  BIOMD0000001039  BIOMD0000001029  BIOMD0000001027 

Last updated by: Krishna Kumar Tiwari

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How to cite BioModels

Rahuman S Malik-Sheriff, Mihai Glont, Tung V N Nguyen, Krishna Tiwari, Matthew G Roberts, Ashley Xavier, Manh T Vu, Jinghao Men, Matthieu Maire, Sarubini Kananathan, Emma L Fairbanks, Johannes P Meyer, Chinmay Arankalle, Thawfeek M Varusai, Vincent Knight-Schrijver, Lu Li, Corina Dueñas-Roca, Gaurhari Dass, Sarah M Keating, Young M Park, Nicola Buso, Nicolas Rodriguez, Michael Hucka, and Henning Hermjakob
Nucl. Acids Res. 2020
Mihai Glont, Tung V N Nguyen, Martin Graesslin, Robert Hälke, Raza Ali, Jochen Schramm, Sarala M Wimalaratne, Varun B Kothamachu, Nicolas Rodriguez, Maciej J Swat, Jurgen Eils, Roland Eils, Camille Laibe, Rahuman S Malik-Sheriff, Vijayalakshmi Chelliah, Nicolas Le Novère, and Henning Hermjakob
Nucl. Acids Res. 2018