- Rodrigues2019 - A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia
- Trisilowati2018 - Optimal control of tumor-immune system interaction with treatment
- Kogan2013 - A mathematical model for the immunotherapeutic control of the TH1 TH2 imbalance in melanoma
- Munz2009 - Zombie SIZRC
- Manda2019 - Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine response
- Giani2018 - Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells
- Moreno2019 - Stochastic model of G1 arrest due to proteostasis decline delimits replicative lifespan in yeast
- Kholodenko1999 - EGFR signaling
- Whole Genome Metabolism - Streptococcus pneumoniae (strain AP200)
- Whole Genome Metabolism - Escherichia coli (strain SE11)
- Uhlén2017 - TCGA-F2-6879-01A - Pancreatic Adenocarcinoma (male, 58 years)
- Whole Genome Metabolism - Clostridium botulinum BKT015925
- Whole Genome Metabolism - Bacillus cereus (strain AH820)
- Whole Genome Metabolism - Burkholderia xenovorans (strain LB400)
One aspect of reinforcement learning is the reward prediction error (RPE), characterised neurophysiologically by transient changes in neuromodulators such as dopamine, acetylcholine and adenosine that act upon receptors expressed by medium spiny neurons. Extracellular binding of these neuromodulators is transduced intracellularly by GPCRs and converge on the adenylyl cyclase/cAMP/PKA pathway, with PKA activation in MSNs being crucial for long-term plasticity and learning. This model studies how interactions between the different neuromodulators can mediate signal filtering, PKA activation, and the production of RPEs essential for reinforcement learning.
The new website will transition from beta to production on 25 June 2018.
12 Jun 2018 at 11:02
BioModels now hosts 6753 models derived from biological samples collected from patients.
21 Aug 2017 at 10:00
We are extremely happy to announce the 31st release of BioModels!
26 Jun 2017 at 02:20
The metabolic network and logical models hosted in the literature-based branch of BioModels can now be downloaded from our FTP server.
16 Jan 2017 at 04:15
The paper, entitled Mechanistic models on neurodegenerative disease processes, available from CPT:PSP
09 Jan 2017 at 09:03