December, 2021
Zake2021 - PBPK model of metformin in mice and humans
Model(s) associated with this Model of the Month: BIOMD0000001039 BIOMD0000001029 BIOMD0000001028 BIOMD0000001027
Last updated by: Krishna Kumar Tiwari
BioModels is a repository of mathematical models of biological and biomedical systems. It hosts a vast selection of existing literature-based physiologically and pharmaceutically relevant mechanistic models in standard formats. Our mission is to provide the systems modelling community with reproducible, high-quality, freely-accessible models published in the scientific literature. More information about using BioModels such as model submission, update, publication can be found in the FAQ.
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833 models
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Recently published
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Caruso2020 - Alternative Complement Pathway model
Submitter: Robin Denhardt-Eriksson | Published date: 2022-06-27Publication: Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease., PLoS computational biology (2020) -
Gautam2020-Metabolic network of Thermotoga sp. Strain RQ7
Submitter: Mikal Daou | Published date: 2022-06-21Publication: Construction and Validation of a Genome-Scale Metabolic Network of Thermotoga sp. Strain RQ7., Applied biochemistry and biotechnology (2021) -
Montagud2022 - Prostate cancer Boolean model
Submitter: Montagud A | Published date: 2022-06-22Publication: Patient-specific Boolean models of signalling networks guide personalised treatments., eLife (2022) -
Puniya2021 - Naive CD4+ T cell metabolic model
Submitter: Mikal Daou | Published date: 2022-06-21Publication: Integrative computational approach identifies drug targets in CD4+ T-cell-mediated immune disorders, NPJ Systems Biology and Applications (2021) -
Canto-Encalada2022-FBA of simultaneous degradation of ammonia and pollutants
Submitter: Mikal Daou | Published date: 2022-06-27Publication: Flux balance analysis of the ammonia-oxidizing bacterium Nitrosomonas europaea ATCC19718 unravels specific metabolic activities while degrading toxic compounds., PLoS computational biology (2022) -
CVS model
Submitter: Ilya Kiselev | Published date: 2022-06-28Publication: Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease., Frontiers in physiology (2021) -
COVID-19 immunotherapy A mathematical model
Submitter: João Nuno Domingues Tavares | Published date: 2022-06-22Publication: COVID-19 immunotherapy A mathematical model I, Preprint (2022)
Recently accessed
- Novak1997 - Cell Cycle
- Talemi2014 - Arsenic toxicity and detoxification mechanisms in yeast
- Brännmark2013 - Insulin signalling in human adipocytes (normal condition)
- Haffez2017 - RAR interaction with synthetic analogues
- Stortelder1997 - Thrombin Generation Amidolytic Activity
- Hettling2011_CreatineKinase
- Bungay2003_Thrombin_Generation
News
- 10/03/2022: Freely create a reviewer account for your models
- 27/02/2021: Reproducibility in Systems Biology Modelling manuscript published
- 23/07/2020: Retirement party for the classic BioModels website
- 19/06/2020: New updates for Release 5.1.9
- 10/06/2020: New updates for Release 5.1.8
- 05/06/2020: BioModels Parameters Manuscript accepted
- 17/01/2020: Planned maintenance
- 12/06/2018: Planned upgrades to BioModels
- 21/08/2017: Patient-derived genome-scale metabolic models
- 26/06/2017: 31st release of BioModels
How to cite BioModels
- Rahuman S Malik-Sheriff, Mihai Glont, Tung V N Nguyen, Krishna Tiwari, Matthew G Roberts, Ashley Xavier, Manh T Vu, Jinghao Men, Matthieu Maire, Sarubini Kananathan, Emma L Fairbanks, Johannes P Meyer, Chinmay Arankalle, Thawfeek M Varusai, Vincent Knight-Schrijver, Lu Li, Corina Dueñas-Roca, Gaurhari Dass, Sarah M Keating, Young M Park, Nicola Buso, Nicolas Rodriguez, Michael Hucka, and Henning Hermjakob
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Nucl. Acids Res. 2020
- Mihai Glont, Tung V N Nguyen, Martin Graesslin, Robert Hälke, Raza Ali, Jochen Schramm, Sarala M Wimalaratne, Varun B Kothamachu, Nicolas Rodriguez, Maciej J Swat, Jurgen Eils, Roland Eils, Camille Laibe, Rahuman S Malik-Sheriff, Vijayalakshmi Chelliah, Nicolas Le Novère, and Henning Hermjakob
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Nucl. Acids Res. 2018
Documentation
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BioModels provides online courses, please consult more information.
Acknowledgements
- BioModels is supported by the European Molecular Biology Laboratory, the Biotechnology and Biological Sciences Research Council (Multimod, BB/N019482/1) and the Innovative Medicines Initiative (TransQST, 116030).
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