BioModels is a repository of mathematical models of biological and biomedical systems.
It hosts a vast selection of existing literature-based physiologically and pharmaceutically
relevant mechanistic models in standard formats. Our mission is to provide the systems
modelling community with reproducible, high-quality,
models published in the scientific literature. More information about using BioModels such as model submission, update, publication, or reviewers access
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DeBoeck2021 - Modular approach to modelling the cell cycle
To multiply, a cell goes through a sequence of phases in the cell division cycle. The transitions between these phases are quick and robust due to a so-called bistable switch. Moreover, lowering cyclin B values does not immediately lead to mitotic exit – the threshold for inactivation of Cdk1 is lower than its activation threshold, leading to hysteresis. In our paper, we propose a solution to this problem. We modify a Hill-type ultrasensitive response such that it produces a bistable response. These bistable responses can, just like Hill functions, be included directly in larger models.
Publication: Genome-scale flux balance analysis reveals redox trade-offs in the metabolism of the thermoacidophile Methylacidiphilum fumariolicum under auto-, hetero-and methanotrophic conditions, Frontiers in Systems Biology (2024)
Rahuman S Malik-Sheriff, Mihai Glont, Tung V N Nguyen, Krishna Tiwari,
Matthew G Roberts, Ashley Xavier, Manh T Vu, Jinghao Men, Matthieu Maire, Sarubini Kananathan,
Emma L Fairbanks, Johannes P Meyer,
Chinmay Arankalle, Thawfeek M Varusai, Vincent Knight-Schrijver, Lu Li, Corina Dueñas-Roca, Gaurhari Dass,
Sarah M Keating, Young M Park, Nicola Buso, Nicolas Rodriguez, Michael Hucka, and Henning Hermjakob
Mihai Glont, Tung V N Nguyen, Martin Graesslin, Robert Hälke, Raza Ali, Jochen Schramm,
Sarala M Wimalaratne, Varun B Kothamachu, Nicolas Rodriguez, Maciej J Swat, Jurgen Eils,
Roland Eils, Camille Laibe, Rahuman S Malik-Sheriff, Vijayalakshmi Chelliah, Nicolas Le Novère,
and Henning Hermjakob