You2010_General_Yeast_mRNA_Translation

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MODEL8459127548
Short description

This the model from the article:
A quantitative model for mRNA translation in Saccharomyces cerevisiae.
You T, Coghill GM, Brown AJ. Yeast. 2010 Mar 19. epub ahead of print, PMID: 20306461 , doi: 10.1002/yea.1770
Abstract:
Messenger RNA (mRNA) translation is an essential step in eukaryotic gene expression that contributes to the regulation of this process. We describe a deterministic model based on ordinary differential equations that describe mRNA translation in Saccharomyces cerevisiae. This model, which was parameterized using published data, was developed to examine the kinetic behaviour of translation initiation factors in response to amino acid availability. The model predicts that the abundance of the eIF1-eIF3-eIF5 complex increases under amino acid starvation conditions, suggesting a possible auxiliary role for these factors in modulating translation initiation in addition to the known mechanisms involving eIF2. Our analyses of the robustness of the mRNA translation model suggest that individual cells within a randomly generated population are sensitive to external perturbations (such as changes in amino acid availability) through Gcn2 signalling. However, the model predicts that individual cells exhibit robustness against internal perturbations (such as changes in the abundance of translation initiation factors and kinetic parameters). Gcn2 appears to enhance this robustness within the system. These findings suggest a trade-off between the robustness and performance of this biological network. The model also predicts that individual cells exhibit considerable heterogeneity with respect to their absolute translation rates, due to random internal perturbations. Therefore, averaging the kinetic behaviour of cell populations probably obscures the dynamic robustness of individual cells. This highlights the importance of single-cell measurements for evaluating network properties. Copyright (c) 2010 John Wiley and Sons, Ltd.

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

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Related Publication
  • A quantitative model for mRNA translation in Saccharomyces cerevisiae.
  • You T, Coghill GM, Brown AJ
  • Yeast (Chichester, England) , 10/ 2010 , Volume 27 , pages: 785-800 , PubMed ID: 20306461
  • Physics Department, School of Natural and Computing Sciences, University of Aberdeen, Aberdeen, UK.
  • Messenger RNA (mRNA) translation is an essential step in eukaryotic gene expression that contributes to the regulation of this process. We describe a deterministic model based on ordinary differential equations that describe mRNA translation in Saccharomyces cerevisiae. This model, which was parameterized using published data, was developed to examine the kinetic behaviour of translation initiation factors in response to amino acid availability. The model predicts that the abundance of the eIF1-eIF3-eIF5 complex increases under amino acid starvation conditions, suggesting a possible auxiliary role for these factors in modulating translation initiation in addition to the known mechanisms involving eIF2. Our analyses of the robustness of the mRNA translation model suggest that individual cells within a randomly generated population are sensitive to external perturbations (such as changes in amino acid availability) through Gcn2 signalling. However, the model predicts that individual cells exhibit robustness against internal perturbations (such as changes in the abundance of translation initiation factors and kinetic parameters). Gcn2 appears to enhance this robustness within the system. These findings suggest a trade-off between the robustness and performance of this biological network. The model also predicts that individual cells exhibit considerable heterogeneity with respect to their absolute translation rates, due to random internal perturbations. Therefore, averaging the kinetic behaviour of cell populations probably obscures the dynamic robustness of individual cells. This highlights the importance of single-cell measurements for evaluating network properties.
Contributors
Submitter of the first revision: Tao You
Submitter of this revision: Tao You
Modellers: Tao You

Metadata information

is (1 statement)
BioModels Database MODEL8459127548

isDescribedBy (1 statement)
PubMed 20306461

hasTaxon (1 statement)
isVersionOf (1 statement)
hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


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Non-curated


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  • Model originally submitted by : Tao You
  • Submitted: Aug 11, 2008 1:52:07 PM
  • Last Modified: Mar 23, 2010 11:49:09 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Mar 23, 2010 11:49:09 PM
    • Submitted by: Tao You
    • With comment: Current version of You2010_General_Yeast_mRNA_Translation
  • Version: 1 public model Download this version
    • Submitted on: Aug 11, 2008 1:52:07 PM
    • Submitted by: Tao You
    • With comment: Original import of model

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