Immunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection

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In Healthy State, we demonstrated the controlled expression of sphingolipids and the controlled IL-6,IL-17,IL-23 cytokines signalling via SOCS3 mediated regulation.
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  • Decoding systems immunological model of sphingolipids with IL-6/IL-17/IL-23 axes in L. major infection
  • Shailza Singh, Diksha Jawale, Shweta Khandibharad
  • Biochim Biophys Acta Mol Cell Biol Lipids , 2/ 2023 , Volume 1868 , Issue 2 , pages: 17 , PubMed ID: 36494028
  • National Centre for Cell Science, Pune
  • IL-6, IL-17, IL-23 and IL-1β are the crucial cytokines controlling inflammatory and immune response during L. major infection. During cutaneous leishmaniasis, an important T helper cell type CD4+ Th17 subset plays a deterministic role in lesion formation through channelling infected macrophages and production of IL-1β, IL-6, IL-23 and IFN-γ. Ceramide derived sphingosine precursors may assist in pro-inflammatory cytokine response. However, the role of these metabolites in inflammation with pleiotropic pro-inflammatory cytokines in L. major infection is unknown. The present study indicates IL-6/IL-17/IL-23 and SPHK1-S1P-S1PRs signaling axes with the overexpression of SATB1 aiding in disease progression. Targeting SATB1 might modulate the secretion of pro-inflammatory cytokines and abnormal immune functioning, thereby killing the intracellular parasite. Systems immunological methods assisted in a step towards identifying the key to the mystery of crucial components and serving as an approach for therapeutic intervention in L. major infection
Submitter of the first revision: Shailza Singh
Submitter of this revision: Shailza Singh
Modellers: Shailza Singh

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Mathematical Modelling Ontology Mathematical model

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Healthy with Sensitivity.xml Role of IL6, IL17 and IL23 in healthy state of leishmaniasis 98.15 KB Preview | Download

  • Model originally submitted by : Shailza Singh
  • Submitted: Jan 11, 2023 8:45:33 AM
  • Last Modified: Jan 11, 2023 8:45:33 AM
  • Version: 1 public model Download this version
    • Submitted on: Jan 11, 2023 8:45:33 AM
    • Submitted by: Shailza Singh
    • With comment: Import of Immunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection