Immunological Model of sphingolipids with IL-6/IL-17/IL-23 in L. major infection

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In diseased state, we demonstrated that increase in production of sphingosine-1-phosphate and overexpression of IL-6,lL-17 and IL-23 with SATB1 leads to disease progression.
Related Publication
  • Decoding systems immunological model of sphingolipids with IL-6/IL-17/IL-23 axes in L. major infection
  • Shailza Singh, Diksha Jawale, Shweta Khandibharad
  • Biochim Biophys Acta Mol Cell Biol Lipids , 2/ 2023 , Volume 1868 , Issue 2 , pages: 17 , PubMed ID: 36494028
  • National Centre for Cell Science, Pune
  • IL-6, IL-17, IL-23 and IL-1β are the crucial cytokines controlling inflammatory and immune response during L. major infection. During cutaneous leishmaniasis, an important T helper cell type CD4+ Th17 subset plays a deterministic role in lesion formation through channelling infected macrophages and production of IL-1β, IL-6, IL-23 and IFN-γ. Ceramide derived sphingosine precursors may assist in pro-inflammatory cytokine response. However, the role of these metabolites in inflammation with pleiotropic pro-inflammatory cytokines in L. major infection is unknown. The present study indicates IL-6/IL-17/IL-23 and SPHK1-S1P-S1PRs signaling axes with the overexpression of SATB1 aiding in disease progression. Targeting SATB1 might modulate the secretion of pro-inflammatory cytokines and abnormal immune functioning, thereby killing the intracellular parasite. Systems immunological methods assisted in a step towards identifying the key to the mystery of crucial components and serving as an approach for therapeutic intervention in L. major infection
Submitter of the first revision: Shailza Singh
Submitter of this revision: Shailza Singh
Modellers: Shailza Singh

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disease_state.sbml.xml Role of IL6, IL17 and IL23 in diseased state of leishmaniasis 97.88 KB Preview | Download

  • Model originally submitted by : Shailza Singh
  • Submitted: Jan 11, 2023 8:25:43 AM
  • Last Modified: Jan 11, 2023 8:25:43 AM
  • Version: 1 public model Download this version
    • Submitted on: Jan 11, 2023 8:25:43 AM
    • Submitted by: Shailza Singh
    • With comment: Import of Immunological Model of sphingolipids with IL-6/IL-17/IL-23 in L. major infection