Koeller2021 - PBPK model of ICG liver function tests

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Physiollogically based pharmacokinetic (PBPK) model of indocyanine-green (ICG) liver function tests.
Related Publication
  • Prediction of Survival After Partial Hepatectomy Using a Physiologically Based Pharmacokinetic Model of Indocyanine Green Liver Function Tests.
  • Adrian Köller, Grzegorzewski Jan, Hans-Michael Tautenhahn, Matthias König
  • Frontiers in physiology 2021 , Volume 12 , pages: 730418 , PubMed ID: 34880771
  • Institute for Theoretical Biology, Institute of Biology, Humboldt University, Berlin, Germany
  • The evaluation of hepatic function and functional capacity of the liver are essential tasks in hepatology as well as in hepatobiliary surgery. Indocyanine green (ICG) is a widely applied test compound that is used in clinical routine to evaluate hepatic function. Important questions for the functional evaluation with ICG in the context of hepatectomy are how liver disease such as cirrhosis alters ICG elimination, and if postoperative survival can be predicted from preoperative ICG measurements. Within this work a physiologically based pharmacokinetic (PBPK) model of ICG was developed and applied to the prediction of the effects of a liver resection under various degrees of cirrhosis. For the parametrization of the computational model and validation of model predictions a database of ICG pharmacokinetic data was established. The model was applied (i) to study the effect of liver cirrhosis and liver resection on ICG pharmacokinetics; and (ii) to evaluate the model-based prediction of postoperative ICG-R15 (retention ratio 15 min after administration) as a measure for postoperative outcome. Key results are the accurate prediction of changes in ICG pharmacokinetics caused by liver cirrhosis and postoperative changes of ICG-elimination after liver resection, as validated with a wide range of data sets. Based on the PBPK model, individual survival after liver resection could be classified, demonstrating its potential value as a clinical tool.
Submitter of the first revision: Matthias König
Submitter of this revision: Matthias König
Modellers: Matthias König

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Model files

icg_body_flat.xml ICG PBPK model (SBML) 140.72 KB Preview | Download

Additional files

icg_body.xml ICG PBPK comp model (SBML) 136.67 KB Preview | Download
icg_body_flat.png Visualization of ICG PBPK model 212.67 KB Preview | Download
icg_liver.png Visualization of ICG liver submodel 71.36 KB Preview | Download
icg_liver.xml ICG liver comp submodel (SBML) 29.89 KB Preview | Download

  • Model originally submitted by : Matthias König
  • Submitted: Jan 9, 2023 12:48:44 PM
  • Last Modified: Jan 9, 2023 12:48:44 PM
  • Version: 1 public model Download this version
    • Submitted on: Jan 9, 2023 12:48:44 PM
    • Submitted by: Matthias König
    • With comment: Import of Koeller2021 - PBPK model of ICG liver function tests