Zakhartsev2022 - Constraint-based model of metabolism of Atlantic salmon (Salmo salar)

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Model Identifier
MODEL2207070001
Short description
SALARECON links the Atlantic salmon genome to metabolic fluxes and growth, focusing on energy, amino acid, and nucleotide metabolism.
Format
SBML (L3V1)
Related Publication
  • SALARECON connects the Atlantic salmon genome to growth and feed efficiency.
  • Zakhartsev M, Rotnes F, Gulla M, Øyås O, van Dam JCJ, Suarez-Diez M, Grammes F, Hafþórsson RA, van Helvoirt W, Koehorst JJ, Schaap PJ, Jin Y, Mydland LT, Gjuvsland AB, Sandve SR, Martins Dos Santos VAP, Jon Olav Vik
  • PLoS computational biology , 6/ 2022 , Volume 18 , Issue 6 , pages: e1010194 , DOI: 10.1371/journal.pcbi.1010194
  • Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences (NMBU), Ås, Norway.
  • Atlantic salmon (Salmo salar) is the most valuable farmed fish globally and there is much interest in optimizing its genetics and rearing conditions for growth and feed efficiency. Marine feed ingredients must be replaced to meet global demand, with challenges for fish health and sustainability. Metabolic models can address this by connecting genomes to metabolism, which converts nutrients in the feed to energy and biomass, but such models are currently not available for major aquaculture species such as salmon. We present SALARECON, a model focusing on energy, amino acid, and nucleotide metabolism that links the Atlantic salmon genome to metabolic fluxes and growth. It performs well in standardized tests and captures expected metabolic (in)capabilities. We show that it can explain observed hypoxic growth in terms of metabolic fluxes and apply it to aquaculture by simulating growth with commercial feed ingredients. Predicted limiting amino acids and feed efficiencies agree with data, and the model suggests that marine feed efficiency can be achieved by supplementing a few amino acids to plant- and insect-based feeds. SALARECON is a high-quality model that makes it possible to simulate Atlantic salmon metabolism and growth. It can be used to explain Atlantic salmon physiology and address key challenges in aquaculture such as development of sustainable feeds.
Contributors
Submitter of the first revision: Jon Olav Vik
Submitter of this revision: Jon Olav Vik
Modellers: Jon Olav Vik

Metadata information

hasProperty
Mathematical Modelling Ontology Constraint-based model

Curation status
Non-curated

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salarecon.xml A metabolic model of Atlantic salmon 4.84 MB Preview | Download

  • Model originally submitted by : Jon Olav Vik
  • Submitted: Jul 7, 2022 9:45:53 AM
  • Last Modified: Jul 7, 2022 9:45:53 AM
Revisions
  • Version: 1 public model Download this version
    • Submitted on: Jul 7, 2022 9:45:53 AM
    • Submitted by: Jon Olav Vik
    • With comment: Import of Zakhartsev2022 - Constraint-based model of metabolism of Atlantic salmon (Salmo salar)