COVID-19 immunotherapy A mathematical model

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Model Identifier
MODEL2202230002
Short description
The pandemic caused by SARS-CoV-2 is responsible for terrible health devastation with profoundly harmful consequences for the economic, social and political activities of communities on a global scale. Extraordinary efforts have been made by the world scientific community, who, in solidarity, shared knowledge so that effective vaccines could be produced quickly. However, it is still important to study therapies that can reduce the risk, until group immunity is reached, which, globally, will take a time that is still difficult to predict. On the other hand, the immunity time guaranteed by already approved vaccines is still uncertain. The current study proposes a therapy whose foundation lies in the important role that innate immunity may have, by preventing the disease from progressing to the acute phase that may eventually lead to the patient’s death. Our focus is on NK cells and their relevant role. Natural killer cells (NK) are considered the primary defense lymphocytes against virus-infected cells. They play a critical role in modulating the immune system. Preliminary studies in COVID-19 patients with severe disease, suggest a reduction in the number and function of NK cells, resulting in decreased clearance of infected and activated cells and unchecked elevation of inflammation markers that damage tissue. SARS-CoV-2 infection distorts the immune response towards a highly inflammatory phenotype. Restoring the effector functions of NK cells has the potential to correct the delicate immune balance needed to effectively overcome SARS-CoV-2 infection.
Format
SBML (L2V4)
Related Publication
  • COVID-19 immunotherapy A mathematical model I
  • João Nuno Domingues Tavares, Emilie Gomes
  • Preprint , 1/ 2022 , Other Link (URL): https://www.cmup.pt/bibcite/reference/6814
  • Mathematical Department Faculty of Sciences University of Porto Portugal
  • The pandemic caused by SARS-CoV-2 is responsible for a terrible health devastation with profoundly harmful consequences for the economic, social and political activities of communities on a global scale. Extraordinary efforts have been made by the world scientific community, who, in solidarity, shared knowledge so that effective vaccines could be produced quickly. However, it is still important to study therapies that can reduce the risk, until group immunity is reached, which, globally, will take a time that is still difficult to predict. On the other hand, the immunity time guaranteed by already approved vaccines is still uncertain. The current study proposes a therapy whose foundation lies in the important role that innate immunity may have, by preventing the disease from progressing to the acute phase that may eventually lead to the patient’s death. Our focus is on NK cells and their relevant role. Natural killer cells (NK) are considered the primary defense lymphocytes against virus-infected cells. They play a critical role in modulating the immune system. Preliminary studies in COVID-19 patients with severe disease, suggest a reduction in the number and function of NK cells, resulting in decreased clearance of infected and activated cells and unchecked elevation of inflammation markers that damage tissue. SARS-CoV-2 infection distorts the immune response towards a highly inflammatory phenotype. Restoring the effector functions of NK cells has the potential to correct the delicate immune balance needed to effectively overcome SARS-CoV-2 infection.
Contributors
Submitter of the first revision: João Nuno Domingues Tavares
Submitter of this revision: João Nuno Domingues Tavares
Modellers: João Nuno Domingues Tavares

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Non-curated


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COVID19 immunotherapy a Mathematical Model.xml Main Copasi model that supports the work intitled "COVID-19 immunotherapy A mathematical model", submitted to Mathematical Medicine and Biology: A Journal of the IMA, Manuscript ID MMB-21-040.R3 114.35 KB Preview | Download

  • Model originally submitted by : João Nuno Domingues Tavares
  • Submitted: Feb 23, 2022 11:52:15 AM
  • Last Modified: Jun 22, 2022 9:37:36 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Jun 22, 2022 9:37:36 AM
    • Submitted by: João Nuno Domingues Tavares
    • With comment: Model revised without commit message
  • Version: 1 public model Download this version
    • Submitted on: Feb 23, 2022 11:52:15 AM
    • Submitted by: João Nuno Domingues Tavares
    • With comment: Import of COVID-19 immunotherapy A mathematical model

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