Nwabugwu2013 - A Tumor-Immune Mathematical Model of CD4+ T Helper Cell
Model Identifier
MODEL2007090001
Short description
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<p>Its a mathematical model presenting the interaction between a growing tumor and immune system. Model involves tumor cells, dendritic cell, helper Tcells, regulatory Tcells, effector cells and certain cytokines (e.g. TGFbeta, IL10, IL2 ) produced by these cells. It represent a dynamic regulation of tumor production/killing by different immune cells and cytokines. Model is derived from Tessi-Roberton 2012</p>
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Format
SBML
(L2V4)
Related Publication
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A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation.
- Nwabugwu CI, Rakhra K, Felsher DW, Paik DS
- Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference , 1/ 2013 , Volume 2013 , pages: 4529-4532 , PubMed ID: 24110741
- Electrical Engineering Department, Stanford University, Stanford CA 94305 USA;
- Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.
Contributors
Submitter of the first revision: Krishna Kumar Tiwari
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Krishna Kumar Tiwari
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Krishna Kumar Tiwari
Metadata information
isDescribedBy (1 statement)
hasTaxon (1 statement)
hasProperty (11 statements)
hasPart (1 statement)
isPropertyOf (1 statement)
hasTaxon (1 statement)
hasProperty (11 statements)
Gene Ontology
T cell mediated cytotoxicity directed against tumor cell target
Brenda Tissue Ontology helper T-lymphocyte
Gene Ontology T cell mediated immune response to tumor cell
Gene Ontology transforming growth factor beta production
Brenda Tissue Ontology regulatory T-lymphocyte
Brenda Tissue Ontology helper T-lymphocyte
Gene Ontology T cell mediated immune response to tumor cell
Gene Ontology transforming growth factor beta production
Brenda Tissue Ontology regulatory T-lymphocyte
NCIt
Immunotherapy
NCIt Transforming Growth Factor
NCIt Dendritic Cell
NCIt Effector Memory T-Lymphocyte
NCIt CD4-Positive T-Lymphocyte
NCIt Transforming Growth Factor
NCIt Dendritic Cell
NCIt Effector Memory T-Lymphocyte
NCIt CD4-Positive T-Lymphocyte
hasPart (1 statement)
isPropertyOf (1 statement)
Curation status
Non-curated
Modelling approach(es)
Tags
Connected external resources
SBGN view in Newt Editor
| Name | Description | Size | Actions |
|---|---|---|---|
Model files |
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| 24110741_Nwabugwu.xml | SBML L2V4 file | 159.26 KB | Preview | Download |
Additional files |
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| 24110741_Nwabugwu.cps | COPASI 4.27 | 201.21 KB | Preview | Download |
- Model originally submitted by : Krishna Kumar Tiwari
- Submitted: Jul 9, 2020 3:11:13 PM
- Last Modified: Jul 9, 2020 3:11:13 PM
Revisions
-
Version: 2
- Submitted on: Jul 9, 2020 3:11:13 PM
- Submitted by: Krishna Kumar Tiwari
- With comment: Edited model metadata online.