Novak1998 - Mathematical model of fission yeast cell cycle
Model Identifier
MODEL2003190004
Short description
Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions. Model encoded by Matthieu Maire and submitted to BioModels by Krishna kumar Tiwari.
Format
SBML
(L2V4)
Related Publication
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Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions.
- Bela Novak, Attila Csikász-Nagy, Gyorffy B, Chen K, Tyson JJ
- Biophysical chemistry , 5/ 1998 , Volume 72 , Issue 1-2 , pages: 185-200 , PubMed ID: 9652094
- Department of Agricultural Chemical Technology, Technical University of Budapest, Hungary. bnovak@chem.bme.hu
- All events of the fission yeast cell cycle can be orchestrated by fluctuations of a single cyclin-dependent protein kinase, the Cdc13/Cdc2 heterodimer. The G1/S transition is controlled by interactions of Cdc13/Cdc2 and its stoichiometric inhibitor, Rum1. The G2/M transition is regulated by a kinase-phosphatase pair, Wee1 and Cdc25, which determine the phosphorylation state of the Tyr-15 residue of Cdc2. The meta/anaphase transition is controlled by interactions between Cdc13/Cdc2 and the anaphase promoting complex, which labels Cdc13 subunits for proteolysis. We construct a mathematical model of fission yeast growth and division that encompasses all three crucial checkpoint controls. By numerical simulations we show that the model is consistent with a broad selection of cell cycle mutants, and we predict the phenotypes of several multiple-mutant strains that have not yet been constructed.
Contributors
Submitter of the first revision: Krishna Kumar Tiwari
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Krishna Kumar Tiwari
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Krishna Kumar Tiwari
Metadata information
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hasProperty (1 statement)
hasProperty (1 statement)
Curation status
Non-curated
Modelling approach(es)
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| Name | Description | Size | Actions |
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Model files |
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| Novak1998.xml | SBML L2V4 file for the model | 72.52 KB | Preview | Download |
Additional files |
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| Novak1998.cps | Copasi 4.27(build217) file for the model | 122.82 KB | Preview | Download |
| Novak1998.sedml | SEDML file for the model | 11.76 KB | Preview | Download |
- Model originally submitted by : Krishna Kumar Tiwari
- Submitted: Mar 19, 2020 4:34:56 PM
- Last Modified: Mar 19, 2020 4:34:56 PM
Revisions
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Version: 1
- Submitted on: Mar 19, 2020 4:34:56 PM
- Submitted by: Krishna Kumar Tiwari
- With comment: Import of Novak1998 - Mathematical model of fission yeast cell cycle