Nanda2013 - B cell chronic lymphocytic leukemia A model with immune response

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Model Identifier
MODEL2001090002
Short description
<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <pre>B cell chronic lymphocytic leukemia - A model with immune response Seema Nanda 1, , Lisette dePillis 2, and Ami Radunskaya 3, 1. Tata Institute of Fundamental Research, Centre for Applicable Mathematics, Bangalore 560065, India 2. Department of Mathematics, Harvey Mudd College, Claremont, CA 91711 3. Department of Mathematics, Pomona College, Claremont, CA, 91711, United States Abstract B cell chronic lymphocytic leukemia (B-CLL) is known to have substantial clinical heterogeneity. There is no cure, but treatments allow for disease management. However, the wide range of clinical courses experienced by B-CLL patients makes prognosis and hence treatment a significant challenge. In an attempt to study disease progression across different patients via a unified yet flexible approach, we present a mathematical model of B-CLL with immune response, that can capture both rapid and slow disease progression. This model includes four different cell populations in the peripheral blood of humans: B-CLL cells, NK cells, cytotoxic T cells and helper T cells. We analyze existing data in the medical literature, determine ranges of values for parameters of the model, and compare our model outcomes to clinical patient data. The goal of this work is to provide a tool that may shed light on factors affecting the course of disease progression in patients. This modeling tool can serve as a foundation upon which future treatments can be based. Keywords: NK cell, chronic lymphocytic leukemia, mathematical model, T cell., B-CLL.</pre> </body> </notes>
Format
SBML (L2V4)
Related Publication
  • B cell chronic lymphocytic leukemia - A model with immune response
  • Seema Nanda 1, , Lisette dePillis 2, and Ami Radunskaya 3,
  • DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS SERIES , 6/ 2013 , Volume 18 , Issue 4 , DOI: 10.3934/dcdsb.2013.18.1053
  • 1 Tata Institute of Fundamental Research, Centre for Applicable Mathematics Bangalore 560065, India 2 Department of Mathematics, Harvey Mudd College Claremont, CA, 91711, USA 3 Department of Mathematics, Pomona College Claremont, CA, 91711, USA
  • B cell chronic lymphocytic leukemia (B-CLL) is known to havesubstantial clinical heterogeneity. There is no cure, but treatments allow fordisease management. However, the wide range of clinical courses experiencedby B-CLL patients makes prognosis and hence treatment a significant chal-lenge. In an attempt to study disease progression across different patients viaa unified yet flexible approach, we present a mathematical model of B-CLLwith immune response, that can capture both rapid and slow disease progres-sion. This model includes four different cell populations in the peripheral bloodof humans: B-CLL cells, NK cells, cytotoxic T cells and helper T cells. Weanalyze existing data in the medical literature, determine ranges of values forparameters of the model, and compare our model outcomes to clinical patientdata. The goal of this work is to provide a tool that may shed light on factorsaffecting the course of disease progression in patients. This modeling tool canserve as a foundation upon which future treatments can be based.
Contributors
Submitter of the first revision: Mohammad Umer Sharif Shohan
Submitter of this revision: Mohammad Umer Sharif Shohan
Modellers: Mohammad Umer Sharif Shohan

Metadata information

isDescribedBy (2 statements)
isDerivedFrom (3 statements)
Taxonomy Homo sapiens
Mathematical Modelling Ontology Ordinary differential equation model
BioModels Database MODEL1907260001

hasProperty (2 statements)
Mathematical Modelling Ontology Ordinary differential equation model
Taxonomy Homo sapiens

isVersionOf (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Non-curated
Modelling approach(es)
ordinary differential equation model
Tags
Immuno-oncology

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Model files
Nanda2013.xml SBML L2V4 Nanda2013 - B cell chronic lymphocytic leukemia - A model with immune response 49.29 KB Preview | Download

Additional files
Nanda2013.cps COPASI version 4.24 (Build 197) Nanda2013 - B cell chronic lymphocytic leukemia - A model with immune response 100.67 KB Preview | Download

  • Model originally submitted by : Mohammad Umer Sharif Shohan
  • Submitted: Jan 9, 2020 1:35:59 PM
  • Last Modified: Jan 9, 2020 1:35:59 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Jan 9, 2020 1:35:59 PM
    • Submitted by: Mohammad Umer Sharif Shohan
    • With comment: Edited model metadata online.