Manda2019 - Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine response

  public model
Model Identifier
MODEL1911280002
Short description 
This is a within-host hepatitis B viral mathematical model for hepatitis B in the acute phase of infection. The model incorporates hepatocytes, hepatitis B virus, immune system cells and cytokine dynamics using a system of ordinary differential equations.
Format
SBML (L2V4)
Related Publication
  • Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine responses
  • Manda, E.C., Chirove, F.
  • Theory in Biosciences , 10/ 2019 , DOI: 10.1007/s12064-019-00305-2
  • University of KwaZulu-Natal, Pietermaritzburg, South Africa
  • We formulate and analyze a within-host hepatitis B viral mathematical model for hepatitis B in the acute phase of infection. The model incorporates hepatocytes, hepatitis B virus, immune system cells and cytokine dynamics using a system of ordinary differential equations. We use the model to demonstrate the trends of the hepatitis B infection qualitatively without the effects of immune cells and cytokines. Using these trends, we tested the effects of incorporating the immune cells only and immune cells with cytokine responses at low and high inhibitions on the hepatitis B virus infection. Our results showed that it is impossible to have the immune cells work independently from cytokines when there is an acute hepatitis B virus infection. Therefore, our results suggest that incorporating immune cells and cytokine dynamics in the acute hepatitis B virus infection stage delays infection in the hepatocytes and excluding such dynamics speeds up infection during this phase. Results from this study are useful in developing strategies for control of hepatocellular carcinoma which is caused by hepatitis B virus infection.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Johannes Meyer
Modellers: Johannes Meyer

Metadata information

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (4 statements)
Mathematical Modelling Ontology Ordinary differential equation model
NCIt Cytokine
Cell Type Ontology helper T cell
Cell Type Ontology cytotoxic T cell

Curation status
Non-curated
Tags

Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files
Manda2019.xml SBML L2V4 Representation of Manda2019 - Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine response 67.23 KB Preview | Download

Additional files
Manda2019.cps COPASI file of Manda2019 - Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine response 145.23 KB Preview | Download

  • Model originally submitted by : Johannes Meyer
  • Submitted: Nov 28, 2019 3:09:49 PM
  • Last Modified: Nov 28, 2019 3:09:49 PM
Revisions
  • Version: 1 public model Download this version
    • Submitted on: Nov 28, 2019 3:09:49 PM
    • Submitted by: Johannes Meyer
    • With comment: Import of Manda2019 - Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine response