Yu2019 - A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor

  public model
Model Identifier
MODEL1911270002
Short description 
This is a mathematical model investigating interactions among malignant tumor cells, CD4+ T cells, anti-tumor cytokines (specifically IFN-gamma), and the immune checkpoint inhibitor CTLA-4 to assess the importance of immune checkpoints in mediating tumor regression.
Format
SBML (L2V4)
Related Publication
  • A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor
  • Yu, J.-L., Jang, S.R.-J.
  • Applied Mathematics and Computation , 12/ 2019 , Volume 362 , DOI: 10.1016/j.amc.2019.06.037
  • Department of Data Science and Big Data Analytics, Providence University, Taichung City, 43301, Taiwan
  • Blockade of immune checkpoints has recently been shown as a revolutionary strategy in the fight against cancers. Based on recent mouse experiments and clinical trials, large tumors can be completely suppressed with an additional blockade of immune checkpoints. We construct mathematical models capturing key interactions among malignant tumor cells, CD4+ T cells, anti-tumor cytokines, and immune checkpoint inhibitor of CTLA-4 to explore the importance of immune checkpoints on regression of tumor. Our study shows that blockade of immune checkpoints plays essential roles in immune responses. Continuous and one day pulse immune therapies by either T cells, anti-tumor cytokines, anti-CTLA-4 or a joint therapy are administered to exam the effectiveness of immune therapies. Our investigation indicates anti-tumor cytokine is potentially a key factor in determining the future of the malignant tumor. The malignant tumor can be suppressed thoroughly with reasonable dosages of anti-tumor cytokines if pre-radiation along with anti-CTLA-4 therapy are implemented.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Johannes Meyer
Modellers: Johannes Meyer

Metadata information

hasTaxon (1 statement)
Taxonomy Mus musculus

hasProperty (4 statements)
Curation status
Non-curated
Tags
Immuno-oncology

Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files
Yu2019.xml SBML L2V4 Representation of Yu2019 - A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor 32.71 KB Preview | Download

Additional files
Yu2019.cps COPASI file of Yu2019 - A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor 73.85 KB Preview | Download

  • Model originally submitted by : Johannes Meyer
  • Submitted: Nov 27, 2019 1:15:54 PM
  • Last Modified: Nov 27, 2019 1:15:54 PM
Revisions
  • Version: 1 public model Download this version
    • Submitted on: Nov 27, 2019 1:15:54 PM
    • Submitted by: Johannes Meyer
    • With comment: Import of Yu2019 - A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor