Boer1985 - Macrophage T cell interaction in anti-tumor response

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Model Identifier
MODEL1911130003
Short description 
In this paper we present a model of the macrophage
T lymphocyte interactions that generate an
anti-tumor immune response. The modseple cifies i)
induction of cytotoxic T lymphocytes, ii) antigen
presentation by macrophages, which leads to iii)
activation of helper T cells, and iv) production of
lymphoid factors, which induce a) cytotoxic macrophages,
b) T lymphocyte proliferation, and c) an
inflammation reaction. Tumor escape mechanisms
(suppression, antigenic heterogeneity) have been
deliberately omitted from the model.
Format
SBML (L2V4)
Related Publication
  • Macrophage T lymphocyte interactions in the anti-tumor immune response: a mathematical model.
  • De Boer RJ, Hogeweg P, Dullens HF, De Weger RA, Den Otter W
  • Journal of immunology (Baltimore, Md. : 1950) , 4/ 1985 , Volume 134 , Issue 4 , pages: 2748-2758 , PubMed ID: 3156189
  • University of Utrecht, Netherlands
  • In this paper we present a model of the macrophage T lymphocyte interactions that generate an anti-tumor immune response. The model specifies i) induction of cytotoxic T lymphocytes, ii) antigen presentation by macrophages, which leads to iii) activation of helper T cells, and iv) production of lymphoid factors, which induce a) cytotoxic macrophages, b) T lymphocyte proliferation, and c) an inflammation reaction. Tumor escape mechanisms (suppression, antigenic heterogeneity) have been deliberately omitted from the model. This research combines hitherto unrelated or even contradictory data within the range of behavior of one model. In the model behavior, helper T cells play a crucial role: Tumors that differ minimally in antigenicity (i.e., helper reactivity) can differ markedly in rejectability. Immunization yields protection against tumor doses that would otherwise be lethal, because it increases the number of helper T cells. The magnitude of the cytotoxic effector cell response depends on the time at which helper T cells become activated: early helper activity steeply increases the magnitude of the immune response. The type of cytotoxic effector cells that eradicates the tumor depends on tumor antigenicity: lowly antigenic tumors are attacked mainly by macrophages, whereas large highly antigenic tumors can be eradicated by cytotoxic T lymphocytes only.
Contributors
Submitter of the first revision: Krishna Kumar Tiwari
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Krishna Kumar Tiwari

Metadata information

isDescribedBy (1 statement)
PubMed 3156189

Curation status
Non-curated
Tags
Immuno-oncology

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  • Model originally submitted by : Krishna Kumar Tiwari
  • Submitted: Nov 13, 2019 4:24:12 PM
  • Last Modified: Nov 13, 2019 4:24:12 PM
Revisions
  • Version: 1 public model Download this version
    • Submitted on: Nov 13, 2019 4:24:12 PM
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Import of Boer1985 - Macrophage T cell interaction in anti-tumor response