Khan2018 - Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2

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Model Identifier
MODEL1911120001
Short description 
This is a ordinary differential equation-based model of the eukaryotic translation initiation factor (eIF2) phosphorylation pathway, a pathway important for regulating protein synthesis activity in eukaryotic cells. This model is geared towards identification the principal robustness-conferring features of the pathway.
Format
SBML (L2V4)
Related Publication
  • Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2.
  • Khan MF, Spurgeon S, Tobias von der Haar
  • Journal of theoretical biology , 5/ 2018 , Volume 445 , pages: 92-102 , PubMed ID: 29476830
  • School of Engineering and Digital Arts, University of Kent, Canterbury, UK.
  • Phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is one of the best studied and most widely used means for regulating protein synthesis activity in eukaryotic cells. This pathway regulates protein synthesis in response to stresses, viral infections, and nutrient depletion, among others. We present analyses of an ordinary differential equation-based model of this pathway, which aim to identify its principal robustness-conferring features. Our analyses indicate that robustness is a distributed property, rather than arising from the properties of any one individual pathway species. However, robustness-conferring properties are unevenly distributed between the different species, and we identify a guanine nucleotide dissociation inhibitor (GDI) complex as a species that likely contributes strongly to the robustness of the pathway. Our analyses make further predictions on the dynamic response to different types of kinases that impinge on eIF2.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Johannes Meyer
Modellers: Johannes Meyer

Metadata information

hasProperty (3 statements)
Curation status
Non-curated
Modelling approach(es)
ordinary differential equation model
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Model files
Khan2018.xml SBML L2V4 Representation of Khan2018 - Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2 29.38 KB Preview | Download

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Khan2018.cps COPASI file of Khan2018 - Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2 96.39 KB Preview | Download

  • Model originally submitted by : Johannes Meyer
  • Submitted: Nov 12, 2019 10:52:40 AM
  • Last Modified: Nov 12, 2019 10:52:40 AM
Revisions
  • Version: 1 public model Download this version
    • Submitted on: Nov 12, 2019 10:52:40 AM
    • Submitted by: Johannes Meyer
    • With comment: Import of Khan2018 - Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2