Nikolopoulou2018 - Tumour-immune dynamics with an immune checkpoint inhibitor

  public model
Model Identifier
MODEL1908270001
Short description
This is a mathematical model investigating the effects of continuous and intermittent PD-L1 and anti-PD-L1 therapy upon tumor-immune dynamics.
Format
SBML (L2V4)
Related Publication
  • Tumour-immune dynamics with an immune checkpoint inhibitor
  • Nikolopoulou, E., Johnson, L.R., Harris, D., Nagy, J.D., Stites, E.C., Kuang, Y.
  • Letters in Biomathematics , 6/ 2018 , Volume 5 , Issue SUP1 , pages: S137-S159 , DOI: 10.1080/23737867.2018.1440978
  • School of Mathematical & Statistical Sciences, Arizona State University, Tempe, AZ, United States
  • The use of immune checkpoint inhibitors is becoming more commonplace in clinical trials across the nation. Two important factors in the tumour-immune response are the checkpoint protein programmed death-1 (PD-1) and its ligand PD-L1. We propose a mathematical tumour-immune model using a system of ordinary differential equations to study dynamics with and without the use of anti-PD-1. A sensitivity analysis is conducted, and series of simulations are performed to investigate the effects of intermittent and continuous treatments on the tumour-immune dynamics. We consider the system without the anti-PD-1 drug to conduct a mathematical analysis to determine the stability of the tumour-free and tumorous equilibria. Through simulations, we found that a normally functioning immune system may control tumour. We observe treatment with anti-PD-1 alone may not be sufficient to eradicate tumour cells. Therefore, it may be beneficial to combine single agent treatments with additional therapies to obtain a better antitumour response.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Johannes Meyer
Modellers: Johannes Meyer

Metadata information

hasProperty (2 statements)
isDescribedBy (1 statement)
Curation status
Non-curated
Tags
Immuno-oncology

Connected external resources

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Model files
Nikolopoulou2018.xml SBML L2V4 Representation of Nikolopoulou2018 - Tumour-immune dynamics with an immune checkpoint inhibitor 36.84 KB Preview | Download

Additional files
Nikolopoulou2018.cps COPASI file of Nikolopoulou2018 - Tumour-immune dynamics with an immune checkpoint inhibitor 82.23 KB Preview | Download
Nikolopoulou2018.sedml SED-ML file of Nikolopoulou2018 - Tumour-immune dynamics with an immune checkpoint inhibitor 12.75 KB Preview | Download

  • Model originally submitted by : Johannes Meyer
  • Submitted: Aug 27, 2019 11:30:16 AM
  • Last Modified: Aug 27, 2019 11:30:16 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Aug 27, 2019 11:30:16 AM
    • Submitted by: Johannes Meyer
    • With comment: Edited model metadata online.